Gastroenterology
Volume 125, Issue 6 , Pages 1651-1659 , December 2003

Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS

  • Simon P Dunlop

      Affiliations

    • Wolfson Digestive Diseases Centre, University Hospital, Nottingham, England UK
  • ,
  • David Jenkins

      Affiliations

    • Division of Pathology, University Hospital, Nottingham, England UK
  • ,
  • Keith R Neal

      Affiliations

    • Division of Public Health, University Hospital, Nottingham, England UK
  • ,
  • Robin C Spiller

      Affiliations

    • Wolfson Digestive Diseases Centre, University Hospital, Nottingham, England UK
    • Corresponding Author InformationAddress requests for reprints to: Robin Spiller, M.D., Division of Gastroenterology, University Hospital, Nottingham NG7 2UH, England UK fax: (44) 0-115-9422232

Received 18 April 2003 ,Accepted 11 September 2003.

References 

  1. Neal KR, Hebden J, Spiller R. Prevalence of gastrointestinal symptoms six months after bacterial gastroenteritis and risk factors for development of the irritable bowel syndrome (postal survey of patients). BMJ. 1993;314:779–782
  2. Thornley JP, Jenkins D, Neal K, Wright T, Brough J, Spiller RC. Relationship of Campylobacter toxigenicity in vitro to the development of postinfectious irritable bowel syndrome. J Infect Dis. 2001;184:606–609
  3. McKendrick MW, Read NW. Irritable bowel syndrome — post salmonella infection. J Infect. 1994;29:1–3
  4. Gwee KA, Graham JC, McKendrick MW, Collins SM, Marshall JS, Walters SJ, et al. Psychometric scores and persistence of irritable bowel after infectious diarrhoea. Lancet. 1996;347:150–153
  5. Gwee KA, Leong YL, Graham C, McKendrick MW, Collins SM, Walters SJ, et al. The role of psychological and biological factors in postinfective gut dysfunction. Gut. 1999;44:400–406
  6. Spiller RC, Jenkins D, Thornley JP, Hebden JM, Wright T, Skinner M, et al. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut. 2000;47:804–811
  7. Gershon MD. Roles played by 5-hydroxytryptamine in the physiology of the bowel. Aliment Pharmacol Ther. 1999;13(suppl 2):15–30
  8. Linden D, Sharkey K, Mawe G. Inflammation is associated with an increased availability of serotonin from enterochromaffin cells in the guinea pig distal colon. (abstr) FASEB J. 2002;16:A890
  9. Bearcroft CP, Perrett D, Farthing MJ. Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome (a pilot study). Gut. 1998;42:42–46
  10. Thompson WG, Heaton KW, Smyth GT, Smyth C. Irritable bowel syndrome in general practice (prevalence, characteristics, and referral). Gut. 2000;46:78–82
  11. Thompson D, Creed FH, Drossman DA, Heaton KW, Mazzaca G. Functional bowel disease and functional abdominal pain. Gastroenterol Int. 1992;5:75–91
  12. Svedlund J, Sjodin I, Dotevall G. GSRS — a clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease. Dig Dis Sci. 1988;33:129–134
  13. Dimenas E, Glise H, Hallerback B, Hernqvist H, Svedlund J, Wiklund I. Well-being and gastrointestinal symptoms among patients referred to endoscopy owing to suspected duodenal ulcer. Scand J Gastroenterol. 1995;30:1046–1052
  14. Wong E, Guyatt GH, Cook DJ, Griffith LE, Irvine EJ. Development of a questionnaire to measure quality of life in patients with irritable bowel syndrome. Eur J Surg Suppl. 1998;583:50–56
  15. Talley NJ, Phillips SF, Wiltgen CM, Zinsmeister AR, Melton LJ. Assessment of functional gastrointestinal disease (the bowel disease questionnaire). Mayo Clin Proc. 1990;65:1456–1479
  16. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67:361–370
  17. Jenkins D, Balsitis M, Gallivan S, Dixon MF, Gilmour HM, Shepherd NA, et al. Guidelines for the initial biopsy diagnosis of suspected chronic idiopathic inflammatory bowel disease. The British Society of Gastroenterology Initiative. J Clin Pathol. 1997;50:93–105
  18. Austin LL, Dobbins WO. Studies of the rectal mucosa in coeliac sprue (the intraepithelial lymphocyte). Gut. 1988;29:200–205
  19. Fernandez-Banares F, Salas A, Forne M, Esteve M, Espinos J, Viver JM. Incidence of collagenous and lymphocytic colitis (a 5-year population-based study). Am J Gastroenterol. 1999;94:418–423
  20. Baert F, Wouters K, D’Haens G, Hoang P, Naegels S, D’Heygere F, et al. Lymphocytic colitis: a distinct clinical entity? A clinicopathological confrontation of lymphocytic and collagenous colitis. Gut. 1999;45:375–381
  21. Salzmann JL, Peltier-Koch F, Bloch F, Petite JP, Camilleri JP. Morphometric study of colonic biopsies (a new method of estimating inflammatory diseases). Lab Invest. 1989;60:847–851
  22. Weston AP, Biddle WL, Bhatia PS, Miner PB. Terminal ileal mucosal mast cells in irritable bowel syndrome. Dig Dis Sci. 1993;38:1590–1595
  23. O’Sullivan M, Clayton N, Harman I, Bountra C, McLaren A, O’Morain CA. Increased mast cells in the irritable bowel syndrome. Neurogastroenterol Motil. 2000;12:449–457
  24. Dunlop SP, Jenkins D, Spiller RC. Distinctive histological patterns of chronic inflammatory cells in rectal biopsies of patients with different clinical subtypes of IBS. (abstr) Gastroenterology. 2002;122:A316
  25. Tornblom H, Lindberg G, Nyberg B, Veress B. Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome. Gastroenterology. 2002;123:1972–1979
  26. Blennerhassett MG, Vignjevic P, Vermillion DL, Collins SM. Inflammation causes hyperplasia and hypertrophy in smooth muscle of rat small intestine. Am J Physiol. 1992;262:G1041–G1046
  27. Barbara G, Vallance BA, Collins SM. Persistent intestinal neuromuscular dysfunction after acute nematode infection in mice. Gastroenterology. 1997;113:1224–1232
  28. Wheatcroft J, Wakelin D, Jenkins D, Spiller RC. Increased entero-endocrine cell numbers in the Trichinella spiralis infected mouse model of post-infectious bowel dysfunction. (abstr) Gastroenterology. 2002;122:A162
  29. Barrett P, Hobbs RC, Coates PJ, Risdon RA, Wright NA, Hall PA. Endocrine cells of the human gastrointestinal tract have no proliferative capacity. Histochem J. 1995;27:482–486
  30. Brittan M, Wright NA. Gastrointestinal stem cells. J Pathol. 2002;197:492–509
  31. Skipper M, Lewis J. Getting to the guts of enteroendocrine differentiation. Nat Genet. 2000;24:3–4
  32. Chadwick VS, Chen W, Shu D, Paulus B, Bethwaite P, Tie A, et al. Activation of the mucosal immune system in irritable bowel syndrome. Gastroenterology. 2002;122:1778–1783
  33. Plaisancie P, Barcelo A, Moro F, Claustre J, Chayvialle JA, Cuber JC. Effects of neurotransmitters, gut hormones, and inflammatory mediators on mucus discharge in rat colon. Am J Physiol. 1998;275:G1073–G1084
  34. Kuwahara A, Kuramoto H, Kadowaki M. 5-HT activates nitric oxide generating neurons to stimulate chloride secretion in guinea pig distal colon. Am J Physiol. 1998;275:G829–G834
  35. Frieling T, Rupprecht C, Kroese AB, Schemann M. Effects of the inflammatory mediator prostaglandin D2 on submucosal neurons and secretion in guinea pig colon. Am J Physiol. 1994;266:G132–G139
  36. Dunlop SP, Jenkins D, Neal KR, Naesdal J, Borgaonker M, Collins SM, et al. Randomized double-blind placebo-controlled trial of prednisolone in post-infectious irritable bowel syndrome (PI-IBS). Aliment Pharmacol Ther. 2003;18:77–84
  37. Calva JJ, Ruiz-Palacios GM, Lopez-Vidal AB, Ramos A, Bojalil R. Cohort study of intestinal infection with campylobacter in Mexican children. Lancet. 1988;1:503–506
  38. Taylor DN, Echeverria P, Pitarangsi C, Seriwatana J, Bodhidatta L, Blaser MJ. Influence of strain characteristics and immunity on the epidemiology of Campylobacter infections in Thailand. J Clin Microbiol. 1988;26:863–868
  39. Parry S, Stansfield R, Jelley D, Phillips E, Barton JR, Welfare MR. Is irritable bowel syndrome (IBS) more common in patients presenting with bacterial gastro-enteritis? A community-based case-control study. Am J Gastroenterol. 2003;98:327–331
  40. Longstreth GF, Hawkey CJ, Mayer EA, Jones RH, Naesdal J, Wilson IK, et al. Characteristics of patients with irritable bowel syndrome recruited from three sources (implications for clinical trials). Aliment Pharmacol Ther. 2001;15:959–964
  41. Gonsalkorale WM, Houghton LA, Whorwell PJ. Hypnotherapy in irritable bowel syndrome (a large-scale audit of a clinical service with examination of factors influencing responsiveness). Am J Gastroenterol. 2002;97:954–961
  42. Mayer EA. The neurobiology of stress and gastrointestinal disease. Gut. 2000;47:861–869
  43. Elenkov IJ, Webster EL, Torpy DJ, Chrousos GP. Stress, corticotropin-releasing hormone, glucocorticoids, and the immune/inflammatory response (acute and chronic effects). Ann N Y Acad Sci. 1999;876:1–11
  44. Mayer EA, Collins SM. Evolving pathophysiologic models of functional gastrointestinal disorders. Gastroenterology. 2002;122:2032–2048
  45. Qiu BS, Vallence BA, Blennerhassett PA, Collins SM. The role of CD4+ lymphocytes in the susceptibility of mice to stress-induced reactivation of experimental colitis. Nat Med. 1999;5:1178–1182
  46. Santos J, Benjamin M, Yang PC, Prior T, Perdue MH. Chronic stress impairs rat growth and jejunal epithelial barrier function (role of mast cells). Am J Physiol. 2000;278:G847–G854
  47. Houghton LA, Atkinson W, Whitaker RP, Whorwell PJ, Rimmer MJ. Increased platelet depleted plasma 5-hydroxytryptamine concentration following meal ingestion in symptomatic female subjects with diarrhoea predominant irritable bowel syndrome. Gut. 2003;52:663–670
  48. Camilleri M, Atanasova E, Carlson PJ, Ahmad U, Kim HJ, Viramontes BE, et al. Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome. Gastroenterology. 2002;123:425–432
  49. Wheatcroft J, McNaulty W, Jenkins D, Wakelin D, Spiller R. Relationship between inflammatory response and long term entero-endocrine cell hyperplasia following infection with Trichinella spiralis (effect of corticosteroids). (abstr) Gastroenterology. 2003;124:A346
  50. Linden DR, Chen JX, Gershon MD, Sharkey KA, Mawe GM. Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis. Am J Physiol. 2003;285:G207–G216
  51. Meisel JL, Bergman D, Graney D, Saunders DR, Rubin CE. Humanrectal mucosa (proctoscopic and morphological changes caused by laxatives). Gastroenterology. 1977;72:1274–1279

PII: S0016-5085(03)01521-X

doi: 10.1053/j.gastro.2003.09.028

Gastroenterology
Volume 125, Issue 6 , Pages 1651-1659 , December 2003