Gastroenterology
Volume 123, Issue 2 , Pages 632-636 , August 2002

Management of ulcers with adherent clots

References 

  1. Agency for Healthcare Research and Quality . HCUP Nationwide Inpatient Sample. Rockville, MD 1997;
  2. Rockall TA, Logan RF, Devlin HB, Northfield TC. Risk assessment after acute upper gastrointestinal haemorrhage. Gut. 1996;38:316–321
  3. Laine L, Peterson WL. Bleeding peptic ulcer. N Engl J Med. 1994;331:717
  4. Lai KC, Hui WM, Wong BCY, Ching CK, Lam SK. A retrospective and prospective study on the safety of discharging selected patients with duodenal ulcer bleeding on the same day as endoscopy. Gastrointest Endosc. 1997;45:26–30
  5. Cipolletta L, Bianco MA, Rotondano G, Marmo R, Piscopo R. Outpatient management for low-risk nonvariceal upper GI bleeding: a randomized controlled trial. Gastrointest Endosc. 2002;55:1–5
  6. Lee JG, Turnipseed S, Romano PS, Vigil H, Azari R, Melnikoff N, et al. Endoscopy-based triage significantly reduces hospitalization rates and costs of treating upper GI bleeding: a randomized controlled trial. Gastrointest Endosc. 1999;50:755–761
  7. Cook DJ, Salena B, Guyatt GH, Laine L. Endoscopic therapy for acute non-variceal upper gastrointestinal hemorrhage: a meta-analysis. Gastroenterology. 1992;102:139–148
  8. Laine L. Multipolar electrocoagulation in the treatment of active upper gastrointestinal tract hemorrhage: a prospective controlled trial. N Engl J Med. 1987;326:1613–1617
  9. Laine L. Multipolar electrocoagulation in the treatment of peptic ulcers with non-bleeding visible vessels: A prospective, controlled trial. Ann Intern Med. 1989;110:510–514
  10. Laine L, Stein C, Sharma V. A prospective outcome of patients with clot in an ulcer and the effect of irrigation. Gastrointest Endosc. 1996;43:107–110
  11. Jensen DM, Kovacs TOG, Jutabha R, Machicado GA, Gralnek I, Savides TJ, et al. Randomized, trial of medical or endoscopic therapy to prevent recurrent ulcer hemorrhage in patients with adherent clots. Gastroenterology. 2002;123:407–413
  12. Bleau BL, Gostout CJ, Shaw MJ, Keate SRF, Harford WV, Bracy W, et al. Final results: rebleeding from peptic ulcers associated with adherent clots: a prospective randomized controlled study comparing endoscopic therapy with medical therapy (abstr). Gastrointest Endosc. 1997;45:AB87
  13. Laine L, Freeman M, Cohen H. Lack of uniformity in diagnosis of endoscopic prognostic features of bleeding ulcers. Gastrointest Endosc. 1994;40:411–417
  14. Lau JYW, Sung JJY, Chan ACW, Lai GWY, Lau JTF, Ng EKW, et al. Stigmata of hemorrhage in bleeding peptic ulcers: an interobserver agreement study among international experts. Gastrointest Endosc. 1997;46:33–36
  15. Lin HJ, Wang K, Perng CL, Lee FY, Lee CH, Lee SD. Natural history of bleeding peptic ulcers with a tightly adherent blood clot: a prospective observation. Gastrointest Endosc. 1996;43:470–473
  16. Swain CP, Bown SG, Storey DW, Kirkham JS, Northfield TC, Salmon PR. Controlled trial of argon laser photocoagulation in bleeding peptic ulcers. Lancet. 1981;2:1313–1316
  17. Swain CP, Kirkham JS, Salmon PR, Bown SG, Northfield TC. Controlled trial of Nd-YAG laser photocoagulation in bleeding peptic ulcers. Lancet. 1986;1:1113–1117
  18. Balanzo J, Azinz S, Such J, Espinos JC, Guarner C, Cusso X, et al. Endoscopic hemostasis by local injection of epinephrine and polidocanol in bleeding ulcer: a prospective randomized trial. Endoscopy. 1988;20:289–291
  19. Matthewson K, Swain CP, Bland M, Kirkham JS, Bown SG, Northfield TC. Randomized comparison of Nd YAG laser, heater probe, and no endoscopic therapy for bleeding peptic ulcers. Gastroenterology. 1990;98:1239–1244
  20. Jensen DM, Kovacs TOG, Randall GM, Machicado GA, Sue M, Freeman M, et al. Initial results of a randomized controlled study of non-bleeding adherent clots in patients with severe ulcer hemorrhage. (abstr) Gastrointest Endosc. 1993;39:279
  21. Skovlund E. Interim analyses of survival data in cancer clinical trials. Acta Oncologica. 1998;37:645–650
  22. Khuroo MS, Yattoo GN, Javid G, Khan BA, Shah AA, Gulzar GM, et al. A comparison of omeprazole and placebo for bleeding peptic ulcer. N Engl J Med. 1997;336:1054–1058
  23. Javid G, Masoodi I, Zargar SA, Khan B, Yatoo GN, Shah AH, et al. Omeprazole as adjuvant therapy to endoscopic combination injection sclerotherapy for treating bleeding peptic ulcer. Am J Med. 2001;111:280–284
  24. Blum RA, Hung RH, Kidd SL, Shi H, Jennings DE, Greski-Rose PA. Dose-response relationship of lansoprazole to gastric acid antisecretory effects. Aliment Pharmacol Ther. 1998;12:321–327
  25. Schaffalitzky de Muckadell OB, Havelund T, Harling H, Boesby S, Snel P, Vreeburg EM, et al. Effect of omeprazole on the outcome of endoscopically treated bleeding peptic ulcers: randomized double-blind placebo-controlled multicentre study. Scand J Gastroenterol. 1997;32:320–327
  26. Hasselgren G, Lind T, Lundell L, Aadland E, Efskind P, Falk A, et al. Continuous intravenous infusion of omeprazole in elderly patients with peptic ulcer bleeding. Scand J Gastroenterol. 1997;32:328–333
  27. Lin HJ, Lo WC, Lee FY, Perng CL, Tseng GY. A prospective randomized comparative trial showing that omeprazole prevents rebleeding in patients with bleeding peptic ulcer after successful endoscopic therapy. Arch Intern Med. 1998;158:54–58
  28. Lau JYW, Sung JJY, Lee KKC, Yung MY, Wong SKH, Wu JCY, et al. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. N Engl J Med. 2000;343:310–316

☆ Dr. Laine has received research support and consulted for AstraZeneca (Wilmington, DE), Wyeth (Philadelphia, PA).

☆☆ No reprints available.

★ Address correspondence to: Loren Laine, GI Division, Department of Medicine, U.S.C. School of Medicine, 2025 Zonal Avenue, Los Angeles, California 90033. e-mail: llaine@usc.edu; fax: (323) 226-7573.

PII: S0016-5085(02)00140-3

doi: 10.1053/gast.2002.35133

Gastroenterology
Volume 123, Issue 2 , Pages 632-636 , August 2002

Article Tools