Gastroenterology
Volume 120, Issue 4 , Pages 938-945 , March 2001

Tachykinin-dependent and -independent components of peristalsis in the guinea pig isolated distal colon

Received 14 March 2000 ,Accepted 11 October 2000.

References 

  1. Costa M, Brookes SJH, Steele PA, Gibbins I, Burcher E, Kandiah CJ. Neurochemical classification of myenteric neurons in the guinea-pig ileum. Neuroscience. 1996;75:949–967
  2. Kunze WAA, Furness JB. The enteric nervous system and regulation of intestinal motility. Annu Rev Physiol. 1999;61:117–142
  3. Grider JR. Tachykinins as transmitters of ascending contractile component of the peristaltic reflex. Am J Physiol. 1989;257:G709–G714
  4. Lippi A, Santicioli P, Criscuoli M, Maggi CA. Depolarization evoked co-release of tachykinins from enteric nerves in the guinea-pig proximal colon. Naunyn Schmiedebergs Arch Pharmacol. 1998;357:245–251
  5. Maggi CA, Zagorodnyuk V, Giuliani S. Specialization of tachykinin NK1 and NK2 receptors in producing fast and slow atropine-resistant neurotransmission to the circular muscle of the guinea-pig colon. Neuroscience. 1994;63:1137–1152
  6. Portbury AL, Furness JB, Young HM, Southwell BR, Vigna SR. Localization of NK1 receptor immunoreactivity to neurons and interstitial cells of the guinea-pig gastrointestinal tract. J Comp Neurol. 1996;367:342–351
  7. Portbury AL, Furness JB, Southwell BR, Wong H, Walsh JH, Bunnett NW. Distribution of neurokinin-2 receptors in the guinea-pig gastrointestinal tract. Cell Tissue Res. 1996;286:281–292
  8. Sternini C, Su D, Gamp PD, Bunnett NW. Cellular sites of expression of the neurokinin-1 receptor in the rat gastrointestinal tract. J Comp Neurol. 1995;358:531–540
  9. Holzer P, Holzer-Petsche U. Tachykinins in the gut. Part I. Expression, release and motor function. Pharmacol Ther. 1997;73:173–217
  10. Mann PT, Southwell BR, Ding YK, Shigemoto R, Mizuno N, Furness JB. Localization of neurokinin 3 (NK3) receptor immunoreactivity in the rat gastrointestinal tract. Cell Tissue Res. 1997;289:1–9
  11. Lomax AE, Bertrand PP, Furness JB. Identification of the populations of enteric neurons that have NK1 tachykinin receptors in the guinea-pig small intestine. Cell Tissue Res. 1998;294:27–33
  12. Jenkinson KM, Morgan JM, Furness JB, Southwell BR. Neurons bearing NK(3) tachykinin receptors in the guinea-pig ileum revealed by specific binding of fluorescently labelled agonists. Histochem Cell Biol. 1999;112:233–246
  13. Yau WM, Mandel KG, Dorsett JA, Youther ML. Neurokinin3 receptor regulation of acetylcholine release from myenteric plexus. Am J Physiol. 1992;263:G659–G664
  14. Maggi CA, Zagorodnyuk V, Giuliani S. Tachykinin NK3 receptor mediates NANC hyperpolarization and relaxation via nitric oxide release in the circular muscle of the guinea-pig colon. Regul Pept. 1994;53:259–274
  15. Legat FJ, Althuber P, Maier R, Griesbacher T, Lembeck F. Evidence for the presence of NK1 and NK3 receptors on cholinergic neurones in the guinea-pig ileum. Neurosci Lett. 1996;207:125–128
  16. Johnson PJ, Bornstein JC, Burcher E. Roles of neuronal NK1 and NK3 receptors in synaptic transmission during motility reflexes in the guinea-pig ileum. Br J Pharmacol. 1998;124:1375–1384
  17. Lecci A, De Giorgio R, Barthò L, Sternini C, Tramontana R, Corinaldesi R, et al. Tachykinin NK-1 receptor–mediated inhibitory responses in the guinea-pig small intestine. Neuropeptides. 1999;33:91–97
  18. Zagorodnyuk V, Maggi CA. Neuronal tachykinin NK2 receptors mediate release of non-adrenergic non-cholinergic inhibitory transmitters in the circular muscle of guinea-pig colon. Neuroscience. 1995;69:643–650
  19. Maggi CA, Patacchini R, Barthò L, Holzer P, Santicioli P. Tachykinin NK1 and NK2 receptor antagonists and atropine-resistant ascending excitatory reflex to the circular muscle of the guinea-pig ileum. Br J Pharmacol. 1994;112:161–168
  20. Holzer P, Maggi CA. Synergistic role of muscarinic acetylcholine and tachykinin NK2 receptors in intestinal peristalsis. Naunyn Schmiedebergs Arch Pharmacol. 1994;349:194–201
  21. Foxx-Orenstein AE, Grider JR. Regulation of colonic propulsion by enteric excitatory and inhibitory neurotransmitters. Am J Physiol. 1996;271:G433–G437
  22. Giuliani S, Lecci A, Giachetti A, Maggi CA. Tachykinins and reflexely evoked atropine-resistant motility in the guinea pig colon in vivo. J Pharmacol Exp Ther. 1993;265:1224–1231
  23. Crema A, Frigo GM, Lecchini S. A pharmacological analysis of the peristaltic reflex in the isolated colon of the guinea-pig or cat. Br J Pharmacol. 1970;39:334–345
  24. Lecci A, Giuliani S, Tramontana M, De Giorgio R, Maggi CA. The role of tachykinin NK1 and NK2 receptors in atropine-resistant colonic propulsion in anaesthetized guinea-pigs. Br J Pharmacol. 1998;124:27–34
  25. Tonini M, Humphreys CM, Brookes SJH, Maggi CA, Costa M. The role of NK3 receptors on excitatory reflex responses and peristalsis in the guinea-pig small intestine. (abstr) Gastroenterology. 1996;110:A770
  26. Holzer P, Lippe IT, Heinemann A, Barthò L. Tachykinin NK1 and NK2 receptor-mediated control of peristaltic propulsion in the guinea-pig small intestine in vitro. Neuropharmacology. 1998;37:131–138
  27. Johnson PJ, Bornstein JC, Yuan SY, Furness JB. Analysis of contributions of acetylcholine and tachykinins to neuro-neuronal transmission in motility reflexes in the guinea-pig ileum. Br J Pharmacol. 1996;118:973–983
  28. Edmonds-Alt X, Doutremepuich J-D, Heaulme M, Neliat G, Santucci V, Steimberg R, et al. In vitro and in vivo biological activities of SR 140333, a novel potent non-peptide tachykinin NK1 receptor antagonist. Eur J Pharmacol. 1993;250:403–413
  29. Edmonds-Alt X, Bichon D, Ducoux J-P, Heaulme M, Miloux B, Poncelet M, et al. SR 142801, the first potent non-peptide antagonist of the tachykinin NK3 receptor. Life Sci. 1995;56:PL27–PL32
  30. Santicioli P, Giuliani S, Patacchini R, Tramontana M, Criscuoli M, Maggi CA. MEN 11420, a potent and selective tachykinin NK2 receptor antagonist in the guinea-pig and human colon. Naunyn Schmiedebergs Arch Pharmacol. 1997;356:678–688
  31. Tonini M, Onori L, Lecchini S, Frigo G, Perucca E, Crema A. Mode of action of ATP on propulsive activity in rabbit colon. Eur J Pharmacol. 1982;82:21–28
  32. Zagorodnyuk V, Santicioli P, Maggi CA. Tachykinin NK1 but not NK2 receptors mediate non-cholinergic excitatory junction potentials in the circular muscle of the guinea-pig colon. Br J Pharmacol. 1993;110:795–803
  33. Lavin ST, Southwell BR, Murphy R, Jenkinson KM, Furness JB. Activation of neurokinin 1 receptors on interstitial cells of Cajal of the guinea-pig small intestine by substance P. Histochem Cell Biol. 1998;110:263–271
  34. Sanders KM. A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract. Gastroenterology. 1996;111:492–515
  35. Loeffler S, Holzer P, Maggi CA, Kilbinger H. Inhibition by NK1 receptors of the electrically evoked release of acetylcholine from guinea pig myenteric neurones. (abstr) Naunyn Schmiedebergs Arch Pharmacol. 1994;349:352
  36. Holzer P. Involvement of nitric oxide in the substance P-induced inhibition of intestinal peristalsis. Neuroreport. 1997;8:2857–2860
  37. Holzer P, Schluet W, Maggi CA. Substance P stimulates and inhibits intestinal peristalsis via distinct receptors. J Pharmacol Exp Ther. 1995;274:322–328
  38. Waterman SA, Costa M. The role of enteric inhibitory motoneurons in peristalsis in the isolated guinea-pig small intestine. J Physiol. 1994;477:459–468
  39. Waterman SA, Costa M, Tonini M. Accommodation mediated by enteric inhibitory reflexes in the isolated guinea-pig small intestine. J Physiol. 1994;474:539–546
  40. Kilbinger H, Stauss P, Erlhof I, Holzer P. Antagonist discrimination between subtypes of tachykinin receptors in the guinea-pig ileum. Naunyn Schmiedebergs Arch Pharmacol. 1986;334:181–187
  41. Maggi CA, Patacchini R, Meini S, Quartara L, Sisto A, Potier E, et al. Comparison of tachykinin NK1 and NK2 receptors in the circular muscle of the guinea-pig ileum and proximal colon. Br J Pharmacol. 1994;112:150–160
  42. Onori L, Aggio A, Taddei G, Tonini M. Contribution of NK2 tachykinin receptors to propulsion in the rabbit distal colon. Am J Physiol. 2000;278:G137–G147
  43. Ciccocioppo R, Onori L, Messori E, Candura SM, Coccini T, Tonini M. Role of nitric oxide-dependent and -independent mechanisms in peristalsis and accomodation in the rabbit distal colon. J Pharmacol Exp Ther. 1994;270:929–937
  44. Morita K, North RA, Tokimasa T. Muscarinic presynaptic inhibition of synaptic transmission in myenteric plexus of guinea-pig ileum. J Physiol. 1982;333:141–149
  45. Schmidt P, Rasmussen TN, Holst JJ. Nervous control of the release of substance P and neurokinin A from the isolated perfused porcine ileum. J Auton Nerv Syst. 1992;38:85–96
  46. Guard S, Watson SP. Evidence for neurokinin-3 receptor–mediated tachykinin release in the guinea-pig ileum. Eur J Pharmacol. 1987;144:409–412
  47. Patacchini R, Barthò L, Holzer P, Maggi CA. Activity of SR 142801 at peripheral tachykinin receptors. Eur J Pharmacol. 1995;278:17–25
  48. Costa M, Furness JB. The peristaltic reflex: an analysis of the nerve pathways and their pharmacology. Naunyn Schmiedebergs Arch Pharmacol. 1976;294:47–60
  49. Smith TK, Bornstein JC, Furness JB. Distension-evoked ascending and descending reflexes in the circular muscle of guinea-pig ileum: an intracellular study. J Auton Nerv Syst. 1990;29:203–217
  50. Lecci A, Giuliani S, Tramontana M, Meini S, De Giorgio R, Maggi CA. In vivo evidence for the involvement of tachykinin NK3 receptors in the hexamethonium-resistant inhibitory transmission in the rat colon. Naunyn Schmiedebergs Arch Pharmacol. 1996;353:671–679

☆ Supported by funds from the University of Pavia (FAR 1998) and CARIPLO Foundation (to M.T.), Italy, and Morphology/Imaging Core of CURE Digestive Diseases Research Center grants DK 54155 and 41301 (to C.S.).

☆☆ Address requests for reprints to: Marcello Tonini, Ph.D., Division of Clinical and Experimental Pharmacology, Department of Internal Medicine and Therapeutics, University of Pavia, Piazza Botta 10, I-27100 Pavia, Italy. e-mail: tonini@unipv.it; fax: (39) 0382-506419.

PII: S0016-5085(01)42709-0

Gastroenterology
Volume 120, Issue 4 , Pages 938-945 , March 2001

Article Tools

* Image Usage & Resolution