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Gastroenterology
Volume 139, Issue 2
, Pages 632-643.e4
, August 2010
C/EBPα Is Up-regulated in a Subset of Hepatocellular Carcinomas and Plays a Role in Cell Growth and Proliferation
References
- . Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 2007;132:2557–2576
- . Natural history of hepatitis-related hepatocellular carcinoma. World J Gastroenterol. 2008;14:1652–1656
- . C/EBPalpha: a tumour suppressor in multiple tissues?. Biochim Biophys Acta. 2006;1766:88–103
- . C/EBPalpha mutations in acute myeloid leukaemias. Nat Rev Cancer. 2004;4:394–400
- Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B Study. J Clin Oncol. 2008;26:5078–5087
- Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia. Blood. 2006;108:3560–3563
- . In prostate cancer C/EBPalpha promotes cell growth by the loss of interactions with CDK2, CDK4, and E2F and by activation of AKT. Prostate. 2009;69:1001–1016
- CCAAT/enhancer binding protein alpha knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma. Cancer Res. 2005;65:10330–10337
- Establishment of a cell line (HCC-M) from a human hepatocellular carcinoma. Int J Cancer. 1983;32:141–146
- Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101. Mol Cancer Ther. 2003;2:721–728
- Anticancer effects of aloe-emodin on HepG2 cells: cellular and proteomic studies. Proteomics Clin Appl. 2007;1:410–419
- Differential expression of hDAB2IPA and hDAB2IPB in normal tissues and promoter methylation of hDAB2IPA in hepatocellular carcinoma. J Hepatol. 2007;46:655–663
- Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. Genes Dev. 2004;18:912–925
- . De-regulation of common housekeeping genes in hepatocellular carcinoma. BMC Genomics. 2007;8:243
- Positive and negative regulatory elements in the mouse albumin enhancer. Proc Natl Acad Sci U S A. 1989;86:1553–1557
- Identification of CCAAT enhancer binding protein alpha binding sites on the human alpha-fetoprotein gene. Gene. 2007;389:128–135
- . Cyclin A-associated kinase activity is rate limiting for entrance into S phase and is negatively regulated in G1 by p27Kip1. Mol Cell Biol. 1995;15:4347–4352
- . Cancer cell cycles. Science. 1996;274:1672–1677
- . Dephosphorylated C/EBPalpha accelerates cell proliferation through sequestering retinoblastoma protein. Mol Cell Biol. 2005;25:1325–1338
- Down-regulated expression of the CCAAT/enhancer binding protein alpha and beta genes in human hepatocellular carcinoma: a possible prognostic marker. Anticancer Res. 2003;23:351–354
- Metallothionein expression is suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of CCAAT/enhancer binding protein alpha by phosphatidylinositol 3-kinase signaling cascade. Cancer Res. 2007;67:2736–2746
- Reduced expression of C/EBP alpha protein in hepatocellular carcinoma is associated with advanced tumor stage and shortened patient survival. J Cancer Res Clin Oncol. 2009;135:241–247
- Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. Nat Genet. 2001;27:263–270
- Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein alpha activity in lung cancer. J Natl Cancer Inst. 2006;98:396–406
- Tumor suppressor activity of CCAAT/enhancer binding protein alpha is epigenetically down-regulated in head and neck squamous cell carcinoma. Cancer Res. 2007;67:4657–4664
- . TSA downregulates Wilms tumor gene 1 (Wt1) expression at multiple levels. Nucleic Acids Res. 2008;36:4067–4078
- . Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene. Nucleic Acids Res. 2003;31:3123–3133
Conflicts of interest The authors disclose no conflicts.
Funding This work is supported by grants from the Singapore National Medical Research Council (NMRC/1068/2006 and NMRC/1211/2009).
PII: S0016-5085(10)00484-1
doi: 10.1053/j.gastro.2010.03.051
© 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
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Gastroenterology
Volume 139, Issue 2
, Pages 632-643.e4
, August 2010

