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Gastroenterology
Volume 138, Issue 5
, Pages 1772-1782.e4
, May 2010
Short-Chain Fatty Acids Regulate the Enteric Neurons and Control Gastrointestinal Motility in Rats
References
- . The human enteric nervous system. Neurogastroenterol Motil. 2004;16(suppl 1):55–59
- . Intrinsic primary afferent neurones of the digestive tract. Neurogastroenterol Motil. 2004;16(suppl 1):24–27
- . The enteric nervous system and regulation of intestinal motility. Annu Rev Physiol. 1999;61:117–142
- . Characteristics of mucosally projecting myenteric neurones in the guinea-pig proximal colon. J Physiol. 1999;517(Pt 2):533–546
- . Identification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut: activity-induced expression of Fos immunoreactivity. J Neurosci. 1992;12:235–248
- . IL-1beta and IL-6 excite neurons and suppress nicotinic and noradrenergic neurotransmission in guinea pig enteric nervous system. J Clin Invest. 1999;103:1309–1316
- Activity-dependent regulation of tyrosine hydroxylase expression in the enteric nervous system. J Physiol. 2008;586:1963–1975
- . Plasticity of enteric nerve functions in the inflamed and postinflamed gut. Neurogastroenterol Motil. 2009;21:481–491
- . Human mucosa/submucosa interactions during intestinal inflammation: involvement of the enteric nervous system in interleukin-8 secretion. Cell Microbiol. 2005;7:1798–1810
- . Neuroplasticity and neuroprotection in enteric neurons: role of epithelial cells. Biochem Biophys Res Commun. 2009;382:577–582
- . Short chain fatty acids in the human colon. Gut. 1981;22:763–779
- . Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut. 1987;28:1221–1227
- . Resistant starch and “butyrate revolution.”. Food Sci Technol. 2002;13:251–261
- . Utilization of nutrients by isolated epithelial cells of the rat colon. Gastroenterology. 1982;83:424–429
- . Review article: the role of butyrate on colonic function. Aliment Pharmacol Ther. 2008;27:104–119
- Butyrate modulates oxidative stress in the colonic mucosa of healthy humans. Clin Nutr. 2009;28:88–93
- Butyrate inhibits inflammatory responses through NFkappaB inhibition: implications for Crohn's disease. Gut. 2000;47:397–403
- . The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J. 1999;343(Pt 2):281–299
- . Monocarboxylate transporters in the central nervous system: distribution, regulation and function. J Neurochem. 2005;94:1–14
- Resistant starch modulates in vivo colonic butyrate uptake and its oxidation in rats with dextran sulfate sodium-induced colitis. J Nutr. 2004;134:493–500
- . Urocortins and the regulation of gastrointestinal motor function and visceral pain. Peptides. 2004;25:1733–1744
- . Depletion of mesopontine cholinergic and sparing of raphe neurons in multiple system atrophy. Neurology. 2002;59:944–946
- . Role of nitric oxide synthase-containing vascular nerves in cerebrovasodilation elicited from cerebellum. Am J Physiol. 1993;264:R738–R746
- . Quantification of neurons in the myenteric plexus: an evaluation of putative pan-neuronal markers. J Neurosci Methods. 2004;133:99–107
- . Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25:402–408
- . Inhibition of histone deacetylase activity by butyrate. J Nutr. 2003;133(suppl):2485S–2493S
- . Acetylated, propionylated or butyrylated starches raise large bowel short-chain fatty acids preferentially when fed to rats. J Nutr. 2003;133:3523–3528
- . Stereospecific regulation of tyrosine hydroxylase and proenkephalin genes by short-chain fatty acids in rat PC12 cells. Pediatr Res. 2004;55:847–854
- . Differential regulation of the tyrosine hydroxylase and enkephalin neuropeptide transmitter genes in rat PC12 cells by short chain fatty acids: concentration-dependent effects on transcription and RNA stability. Brain Res. 2007;1132:42–50
- . Stimulation of choline acetyltransferase activity by retinoic acid and sodium butyrate in a cultured human neuroblastoma. Brain Res. 1989;478:74–84
- . Histone hyperacetylating agents stimulate promoter activity of human choline acetyltransferase gene in transfection experiment. Brain Res Mol Brain Res. 1996;39:68–78
- Down-regulation of the monocarboxylate transporter 1 is involved in butyrate deficiency during intestinal inflammation. Gastroenterology. 2007;133:1916–1927
- . Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain. Neuroscience. 2003;122:677–688
- Perinatal and early postnatal changes in the expression of monocarboxylate transporters MCT1 and MCT2 in the rat forebrain. J Comp Neurol. 2003;465:445–454
- The relationship between the effects of short-chain fatty acids on intestinal motility in vitro and GPR43 receptor activation. Neurogastroenterol Motil. 2007;19:66–74
- . Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions. J Physiol Pharmacol. 2008;59(suppl 2):251–262
- . Cooperation between phosphorylation and acetylation processes in transcriptional control. Mol Cell Biol. 1999;19:3474–3484
- . Histone deacetylase 3 localizes to the plasma membrane and is a substrate of Src. Oncogene. 2006;25:4495–4500
- . The ubiquitous and tissue specific promoters of the human SRC gene are repressed by inhibitors of histone deacetylases. Oncogene. 2002;21:6340–6347
- . Role of Src tyrosine kinase in the atherogenic effects of the 12/15-lipoxygenase pathway in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2009;29:387–393
- . Src family kinase members have a common response to histone deacetylase inhibitors in human colon cancer cells. Int J Cancer. 2006;118:547–554
- . The luminal short-chain fatty acid butyrate modulates NF-kappaB activity in a human colonic epithelial cell line. Gastroenterology. 2000;118:724–734
- The apoptotic effects and synergistic interaction of sodium butyrate and MG132 in human retinoblastoma Y79 cells. Cancer Res. 1999;59:5586–5595
- . Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes. Proc Natl Acad Sci U S A. 1999;96:13691–13696
- . Contractile effect of short-chain fatty acids on the isolated colon of the rat. J Physiol. 1985;368:667–678
- . Short chain fatty acids in the terminal ileum accelerate stomach to caecum transit time in the rat. Gut. 1991;32:266–269
- Effect of age on the enteric nervous system of the human colon. Neurogastroenterol Motil. 2009;21:746–e46
- . Development of colonic motility in the neonatal mouse-studies using spatiotemporal maps. Am J Physiol Gastrointest Liver Physiol. 2007;292:G930–G938
View this article's video abstract at www.gastrojournal.org.
Conflicts of interest The authors disclose no conflicts.
Funding R.S. is a recipient of a doctoral fellowship from the CRNH of Nantes and the Region of Pays de la Loire. M.N. and P.D. are recipients of a Contrat d'Interface INSERM.
J.P.S. and M.N. contributed equally to this work.
PII: S0016-5085(10)00165-4
doi: 10.1053/j.gastro.2010.01.053
© 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
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Gastroenterology
Volume 138, Issue 5
, Pages 1772-1782.e4
, May 2010

