Gastroenterology
Volume 138, Issue 4 , Pages 1297-1301 , April 2010

The Risk of Esophageal Adenocarcinoma After Antireflux Surgery

  • Jesper Lagergren

      Affiliations

    • Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    • Corresponding Author InformationReprint requests Address requests for reprints to: Jesper Lagergren, MD, PhD, Professor of Surgery, Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-171 76 Stockholm, Sweden. fax: (46) 8-51776280
  • ,
  • Weimin Ye

      Affiliations

    • Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    • Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
  • ,
  • Pernilla Lagergren

      Affiliations

    • Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
  • ,
  • Yunxia Lu

      Affiliations

    • Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    • Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Received 6 October 2009 ,Accepted 6 January 2010.

References 

  1. Devesa SS, Blot WJ, Fraumeni JF. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer. 1998;83:2049–2053
  2. Bollschweiler E, Wolfgarten E, Gutschow C, et al. Demographic variations in the rising incidence of esophageal adenocarcinoma in white males. Cancer. 2001;92:549–555
  3. Jemal A, Murray T, Ward E, et al. Cancer statistics, 2005. CA Cancer J Clin. 2005;55:10–30
  4. Sundelof M, Ye W, Dickman PW, et al. Improved survival in both histologic types of oesophageal cancer in Sweden. Int J Cancer. 2002;99:751–754
  5. Lagergren J, Bergstrom R, Lindgren A, et al. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med. 1999;340:825–831
  6. Chow WH, Finkle WD, McLaughlin JK, et al. The relation of gastroesophageal reflux disease and its treatment to adenocarcinomas of the esophagus and gastric cardia. JAMA. 1995;274:474–477
  7. Chang EY, Morris CD, Seltman AK, et al. The effect of antireflux surgery on esophageal carcinogenesis in patients with Barrett esophagus: a systematic review. Ann Surg. 2007;246:11–21
  8. Shaheen NJ. Does fundoplication change the risk of esophageal cancer in the setting of GERD?. Am J Gastroenterol. 2005;100:1009–1011
  9. Catarci M, Gentileschi P, Papi C, et al. Evidence-based appraisal of antireflux fundoplication. Ann Surg. 2004;239:325–337
  10. Lindblad M, Ye W, Lindgren A, et al. Disparities in the classification of esophageal and cardia adenocarcinomas and their influence on reported incidence rates. Ann Surg. 2006;243:479–485
  11. Breslow NE, Day NE. The design and analysis of cohort studies (IARC scientific publications no 82). Lyon, France: International Agency for Research on Cancer; 1987;
  12. Spechler SJ. Clinical practice (Barrett's esophagus). N Engl J Med. 2002;346:836–842
  13. Dimick JB, Wainess RM, Upchurch GR, et al. National trends in outcomes for esophageal resection. Ann Thorac Surg. 2005;79:212–218
  14. Rouvelas I, Zeng W, Lindblad M, et al. Survival after surgery for oesophageal cancer: a population-based study. Lancet Oncol. 2005;6:864–870
  15. Hampel H, Abraham NS, El-Serag HB. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann Intern Med. 2005;143:199–211
  16. Gammon MD, Schoenberg JB, Ahsan H, et al. Tobacco, alcohol, and socioeconomic status and adenocarcinomas of the esophagus and gastric cardia. J Natl Cancer Inst. 1997;89:1277–1284
  17. Lagergren J, Bergstrom R, Lindgren A, et al. The role of tobacco, snuff and alcohol use in the aetiology of cancer of the oesophagus and gastric cardia. Int J Cancer. 2000;85:340–346
  18. Spechler SJ, Lee E, Ahnen D, et al. Long-term outcome of medical and surgical therapies for gastroesophageal reflux disease: follow-up of a randomized controlled trial. JAMA. 2001;285:2331–2338
  19. Ye W, Chow WH, Lagergren J, et al. Risk of adenocarcinomas of the esophagus and gastric cardia in patients with gastroesophageal reflux diseases and after antireflux surgery. Gastroenterology. 2001;121:1286–1293
  20. Corey KE, Schmitz SM, Shaheen NJ. Does a surgical antireflux procedure decrease the incidence of esophageal adenocarcinoma in Barrett's esophagus? (A meta-analysis). Am J Gastroenterol. 2003;98:2390–2394
  21. Tran T, Spechler SJ, Richardson P, et al. Fundoplication and the risk of esophageal cancer in gastroesophageal reflux disease: a Veterans Affairs cohort study. Am J Gastroenterol. 2005;100:1002–1008
  22. Farrow DC, Vaughan TL, Sweeney C, et al. Gastroesophageal reflux disease, use of H2 receptor antagonists, and risk of esophageal and gastric cancer. Cancer Causes Control. 2000;11:231–238
  23. Garcia Rodriguez LA, Lagergren J, Lindblad M. Gastric acid suppression and risk of oesophageal and gastric adenocarcinoma: a nested case control study in the UK. Gut. 2006;55:1538–1544
  24. Csendes A, Burdiles P, Braghetto I, et al. Adenocarcinoma appearing very late after antireflux surgery for Barrett's esophagus: long-term follow-up, review of the literature, and addition of six patients. J Gastrointest Surg. 2004;8:434–441
  25. Lagergren J, Viklund P. Is esophageal adenocarcinoma occurring late after antireflux surgery due to persistent postoperative reflux?. World J Surg. 2007;31:465–469
  26. Locke GR, Talley NJ, Fett SL, et al. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology. 1997;112:1448–1456
  27. Vakil N, van Zanten SV, Kahrilas P, et al. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101:1900–1920quiz 1943

 Conflicts of interest The authors disclose no conflicts.

 Funding Financial support was provided by the Swedish Cancer Society and the Swedish Research Council. These funders were not involved in the design or implementation of the study; the collection, management, analysis, or interpretation of the data; or the preparation, review, or approval of the manuscript.

PII: S0016-5085(10)00020-X

doi: 10.1053/j.gastro.2010.01.004

Gastroenterology
Volume 138, Issue 4 , Pages 1297-1301 , April 2010