Gastroenterology
Volume 137, Issue 3 , Pages 775-778 , September 2009

Intestinal Lipid Absorption, GLP-2, and CD36: Still More Mysteries to Moving Fat

  • Elizabeth P. Newberry
    • ,
  • Nicholas O. Davidson

      Affiliations

    • Corresponding Author InformationReprint requests Address requests for reprints to: Nicholas O. Davidson, MD, Division of Gastroenterology, Box 8124, Washington University School of Medicine, 660 Euclid Avenue, St. Louis, Missouri 63110. phone: (314) 362-2027

References 

  1. Iqbal J, Hussain MM. Intestinal lipid absorption. Am J Physiol Endocrinol Metab. 2009;296:E1183–E1194
  2. Siddiqi SA, Siddiqi S, Mahan J, et al. The identification of a novel endoplasmic reticulum to Golgi SNARE complex used by the prechylomicron transport vesicle. J Biol Chem. 2006;281:20974–20982
  3. Drover VA, Ajmal M, Nassir F, et al. CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood. J Clin Invest. 2005;115:1290–1297
  4. Hsieh J, Longuet C, Maida A, et al. Glucagon-like peptide-2 increases intestinal lipid absorption and chylomicron production via CD36. Gastroenterology. 2009;137:997–1005
  5. Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007;132:2131–2157
  6. Meier JJ, Nauck MA, Pott A, et al. Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans. Gastroenterology. 2006;130:44–54
  7. Yusta B, Holland D, Koehler JA, et al. ErbB signaling is required for the proliferative actions of GLP-2 in the murine gut. Gastroenterology. 2009;137:986–996
  8. Guan X, Stoll B, Lu X, et al. GLP-2-mediated up-regulation of intestinal blood flow and glucose uptake is nitric oxide-dependent in TPN-fed piglets 1. Gastroenterology. 2003;125:136–147
  9. Hoosdally SJ, Andress EJ, Wooding C, et al. The human scavenger receptor CD36: glycosylation status and its role in trafficking and function. J Biol Chem. 2009;284:16277–16288
  10. Drover VA, Nguyen DV, Bastie CC, et al. CD36 mediates both cellular uptake of very long chain fatty acids and their intestinal absorption in mice. J Biol Chem. 2008;283:13108–13115
  11. Nassir F, Wilson B, Han X, et al. CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine. J Biol Chem. 2007;282:19493–19501
  12. Nauli AM, Nassir F, Zheng S, et al. CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine. Gastroenterology. 2006;131:1197–1207
  13. Xie Y, Newberry EP, Young SG, et al. Compensatory increase in hepatic lipogenesis in mice with conditional intestine-specific Mttp deficiency. J Biol Chem. 2006;281:4075–4086
  14. Luiken JJ, Coort SL, Willems J, et al. Contraction-induced fatty acid translocase/CD36 translocation in rat cardiac myocytes is mediated through AMP-activated protein kinase signaling. Diabetes. 2003;52:1627–1634
  15. Bonen A, Luiken JJ, Arumugam Y, et al. Acute regulation of fatty acid uptake involves the cellular redistribution of fatty acid translocase. J Biol Chem. 2000;275:14501–14508
  16. Nguyen DV, Drover VA, Knopfel M, et al. Influence of class B scavenger receptors on cholesterol flux across the brush border membrane and intestinal absorption. J Lipid Res. 2009 May 19;[Epub ahead of print]
  17. Masuda D, Hirano K, Oku H, et al. Chylomicron remnants are increased in the postprandial state in CD36 deficiency. J Lipid Res. 2009;50:999–1011
  18. Laugerette F, Passilly-Degrace P, et al. CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions. J Clin Invest. 2005;115:3177–3184
  19. Schwartz GJ, Fu J, Astarita G, et al. The lipid messenger OEA links dietary fat intake to satiety. Cell Metab. 2008;8:281–288
  20. Yamashita S, Hirano K, Kuwasako T, et al. Physiological and pathological roles of a multi-ligand receptor CD36 in atherogenesis; insights from CD36-deficient patients. Mol Cell Biochem. 2007;299:19–22
  21. Cohn JS. Are we ready for a prospective study to investigate the role of chylomicrons in cardiovascular disease?. Atheroscler Suppl. 2008;9:15–18

 Conflicts of interest The authors disclose no conflicts.

 Funding Grant awards HL-38180, DK-56260 and DK-52574 to NOD.

PII: S0016-5085(09)01190-1

doi: 10.1053/j.gastro.2009.07.034

Gastroenterology
Volume 137, Issue 3 , Pages 775-778 , September 2009

Article Tools

* Image Usage & Resolution