Gastroenterology
Volume 137, Issue 3 , Pages 772-775 , September 2009

Nonalcoholic Fatty Liver Disease Liver Fat Score and Fat Equation to Predict and Quantitate Hepatic Steatosis: Promising But Not Prime Time!

  • Naga Chalasani

      Affiliations

    • Corresponding Author InformationReprint requests Address requests for reprints to: Naga Chalasani, MD, Professor and Director, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, RG 4100; 1050 Wishard Boulevard, Indiana, Indiana 46202. phone: (317) 278-0414; fax (317) 278-1949

References 

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  2. Cassidy FH, Yokoo T, Aganovic L, et al. Fatty liver disease: MR imaging techniques for the detection and quantification of liver steatosis. Radiographics. 2009;29:231–260
  3. Szczepaniak LS, Babcock EE, Schick F, et al. Measurement of intracellular triglyceride stores by 1H spectroscopy: validation in vivo. Am J Physiol Endocrinol Metab. 1999;276:977–989
  4. Kotronen A, Peltonen M, Hakkarainen A, et al. Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors. Gastroenterology. 2009;137:865–872
  5. Romeo S, Kozlitina J, Xing C, et al. Genetic variation in PNLPA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet. 2008;40:1461–1465
  6. Longo R, Pollesello P, Ricci C, et al. Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis. J Magn Reson Imag. 1995;5:281–285
  7. Vuppalanchi R, Cummings OW, Ulbright T, et al. Hepatic steatosis (Relationship among histological, radiological and biochemical assessments). J Clin Gastroenterol. 2007;41:206–210
  8. Prati D, Taioli E, Zanella A, et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med. 2002;137:1–10
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  10. Chalasani N, Wilson L, Kleiner DE, et al. NASH Clinical Research Network Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with nonalcoholic fatty liver disease. J Hepatol. 2008;48:829–834
  11. Choi SS, Diehl AM. Hepatic triglyceride synthesis and nonalcoholic fatty liver disease. Curr Opin Lipidol. 2008;19:295–300
  12. Sookoian S, Castano GO, Burgueno AL, et al. A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity. J Lipid Res. 2009 May 20;[Epub ahead of print]
  13. Kotronen A, Johansson LE, Johansson LM, et al. A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans. Diabetolgia. 2009;52:1056–1060
  14. Steinberg GR, Kem BE, Watt MJ, et al. Adipocyte triglyceride lipase expression in human obesity. Am J Physiol Endocrinol Metab. 2007;293:E958–E964
  15. Baulande S, Lasnier F, Lucas M, et al. Adiponutrin, a transmembrane protein corresponding to a novel dietary and obesity linked mRNA specifically expressed in the adipose lineage. J Biol Chem. 2001;276:33336–33344
  16. Browning JD, Szczepaniak LS, Dobbins R, et al. Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity. Hepatology. 2004;40:1387–1395
  17. Yuan X, Waterworth D, Perry JRB, et al. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Human Genetics. 2008;83:520–528

 Conflicts of interest The author discloses the following: Dr Chalasani served within the past 12 months as a paid consultant to KariBio, Metabasis, Atherogenics, Advanced Life Sciences, Johnson and Johnson, Debiovision, Eli Lilly, and Amylin. Within the past 12 months, he has participated in clinical studies with Gilead and Monarch LifeSciences.

 Funding Supported in part by K24 DK 069290.

PII: S0016-5085(09)01188-3

doi: 10.1053/j.gastro.2009.07.032

Gastroenterology
Volume 137, Issue 3 , Pages 772-775 , September 2009

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