Gastroenterology
Volume 137, Issue 2 , Pages 440-444 , August 2009

Argon Plasma Coagulation of Cervical Heterotopic Gastric Mucosa as an Alternative Treatment for Globus Sensations

The paper was presented in part at the UEGW 2008 meeting and the annual meeting of the German Society for Metabolic Disorders and Digestive Diseases (DGVS) in 2008.

  • Monther Bajbouj

      Affiliations

    • II. Medical Clinic, Klinikum Rechts der Isar, Technical University of Munich, Germany
  • ,
  • Valentin Becker

      Affiliations

    • II. Medical Clinic, Klinikum Rechts der Isar, Technical University of Munich, Germany
  • ,
  • Florian Eckel

      Affiliations

    • II. Medical Clinic, Klinikum Rechts der Isar, Technical University of Munich, Germany
  • ,
  • Stephan Miehlke

      Affiliations

    • Medical Department I, Technical University Hospital, Dresden, Germany
  • ,
  • Oliver Pech

      Affiliations

    • Medical Department II, D. Horst-Schmidt-Klinik, Wiesbaden, Germany
  • ,
  • Christian Prinz

      Affiliations

    • II. Medical Clinic, Klinikum Rechts der Isar, Technical University of Munich, Germany
  • ,
  • Roland M. Schmid

      Affiliations

    • II. Medical Clinic, Klinikum Rechts der Isar, Technical University of Munich, Germany
  • ,
  • Alexander Meining

      Affiliations

    • II. Medical Clinic, Klinikum Rechts der Isar, Technical University of Munich, Germany
    • Corresponding Author InformationReprint requests Address requests for reprints to: PD Dr med Alexander Meining, II. Medizinische Klinik, Technical University of Munich, Klinikum Rechts der Isar, Ismaningerstr. 22, D-81675 Munich, Germany. fax: (49) 89-4140-4958

Received 1 March 2009 ,Accepted 21 April 2009.

References 

  1. Galmiche JP, Clouse RE, Bálint A, Cook IJ, Kahrilas PJ, Paterson WG, et al. Functional esophageal disorders. Gastroenterology. 2006;130:1459–1465
  2. Ruth M, Månsson I, Sandberg N. The prevalence of symptoms suggestive of esophageal disorders. Scand J Gastroenterol. 1991;26:73–81
  3. Moloy PJ, Charter R. The globus symptom (Incidence, therapeutic response, and age and sex relationships). Arch Otolaryngol. 1982;108:740–744
  4. Thompson WG, Heaton KW. Heartburn and globus in apparently healthy people. Can Med Assoc J. 1982;126:46–48
  5. Bajbouj M, Becker V, Neuber M, Schmid RM, Meining A. Combined pH-metry/impedance monitoring increases the diagnostic yield in patients with atypical gastroesophageal reflux symptoms. Digestion. 2007;76:223–228
  6. Dore MP, Pedroni A, Pes GM, et al. Effect of antisecretory therapy on atypical symptoms in gastroesophageal reflux disease. Dig Dis Sci. 2007;52:463–468
  7. Alaani A, Jassar P, Warfield AT, Gouldesbrough DR, Smith I. Heterotopic gastric mucosa in the cervical oesophagus (inlet patch) and globus pharyngeus--an under-recognised association. J Laryngol Otol. 2007;121:885–888
  8. Akbayir N, Sökmen HM, Caliş AB, et al. Heterotopic gastric mucosa in the cervical esophagus: could this play a role in the pathogenesis of laryngopharyngeal reflux in a subgroup of patients with posterior laryngitis?. Scand J Gastroenterol. 2005;40:1149–1156
  9. Chong VH, Jalihal A. Cervical inlet patch: case series and literature review. South Med J. 2006;99:865–869
  10. Akbayir N, Alkim C, Erdem L, Alkim C, Sakiz D, Mungan Z. Heterotopic gastric mucosa in the cervical esophagus (inlet patch): endoscopic prevalence, histological and clinical characteristics. J Gastroenterol Hepatol. 2004;19:891–896
  11. Tang P, McKinley MJ, Sporrer M, Kahn E. Inlet patch: prevalence, histologic type, and association with esophagitis, Barrett esophagus, and antritis. Arch Pathol Lab Med. 2004;128:444–447
  12. Meining A, Bajbouj M, Preeg M, et al. Argon plasma ablation of gastric inlet patches in the cervical esophagus may alleviate globus sensation: a pilot trial. Endoscopy. 2006;38:566–570
  13. Deary IJ, Wilson JA, Harris MB, MacDougall G. Globus pharyngis: development of a symptom assessment scale. J Psychosom Res. 1995;39:203–213
  14. Klaase JM, Lemaire LC, Rauws EA, Offerhaus GJ, van Lanschot JJ. Heterotopic gastric mucosa of the cervical esophagus: a case of high grade dysplasia treated with argon plasma coagulation and a case of adenocarcinoma. Gastrointestinal Endosc. 2001;53:101–104
  15. Sauve G, Croue A, Dnez B, Beuer J. High-grade dysplasia in heterotopic gastric mucosa in the upper esophagus after radiotherapy: successful eradication 2 years after endoscopic treatment by argon plasma coagulation. Endoscopy. 2001;33:732
  16. Von Rahden BH, Stein HJ, Becker K, Liebermann-Meffert D, Siewert JR. Heterotopic gastric mucosa of the esophagus: literature review and proposal of a clinicopathologic classification. Am J Gastroenterol. 2004;99:543–551
  17. Kim EA, Kang DH, Cho HS, et al. Acid secretion from a heterotopic gastric mucosa in the upper esophagus demonstrated by dual probe 24-hour ambulatory pH monitoring. Korean J Intern Med. 2001;16:14–17
  18. Koufman JA, Aviv JE, Casiano R, Shaw GY. Laryngopharyngeal reflux: position statement of the committee on speech, voice, and swallowing disorders of the American Academy of Otolaryngology-Head and Neck Surgery. Otolaryngol Head Neck Surg. 2002;127:32–35
  19. Corso MJ, Pursnani KG, Mohiuddin MA. Globus sensation is associated with hypertensive upper esophageal sphincter but not with gastroesophageal reflux. Digest Dis Sci. 1998;43:1513–1517
  20. Wilson JA, Heading RC, Maran AD. Globus sensation is not due to gastro-osophageal reflux. Clin Otolaryngol. 1987;12:271–275
  21. Richter JL, Bradley LC. Psychophysiological interactions in esophageal diseases. Semin Gastrointest Dis. 1996;7:169–184

 Conflicts of interest The authors disclose no conflicts.

PII: S0016-5085(09)00719-7

doi: 10.1053/j.gastro.2009.04.053

Gastroenterology
Volume 137, Issue 2 , Pages 440-444 , August 2009