Gastroenterology
Volume 137, Issue 1 , Pages 88-93 , July 2009

Increased Prevalence and Mortality in Undiagnosed Celiac Disease

  • Alberto Rubio–Tapia

      Affiliations

    • Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota
    • ,
  • Robert A. Kyle

      Affiliations

    • Division of Hematology, Mayo Clinic, Rochester, Minnesota
    • ,
  • Edward L. Kaplan

      Affiliations

    • Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota
    • ,
  • Dwight R. Johnson

      Affiliations

    • Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota
    • ,
  • William Page

      Affiliations

    • Medical Follow-Up Agency, Washington, DC
    • ,
  • Frederick Erdtmann

      Affiliations

    • Medical Follow-Up Agency, Washington, DC
    • ,
  • Tricia L. Brantner

      Affiliations

    • Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota
    • ,
  • W. Ray Kim

      Affiliations

    • Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota
    • ,
  • Tara K. Phelps

      Affiliations

    • Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota
    • ,
  • Brian D. Lahr

      Affiliations

    • Division of Biomedical Informatics and Statistics, Mayo Clinic, Rochester, Minnesota
    • ,
  • Alan R. Zinsmeister

      Affiliations

    • Division of Biomedical Informatics and Statistics, Mayo Clinic, Rochester, Minnesota
    • ,
  • L. Joseph Melton III

      Affiliations

    • Division of Epidemiology, Mayo Clinic, Rochester, Minnesota
    • ,
  • Joseph A. Murray

      Affiliations

    • Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota
    • Corresponding Author InformationReprint requests Address requests for reprints to: Joseph A. Murray, MD, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905

Received 4 February 2009 ,Accepted 31 March 2009.

References 

  1. Green PH, Cellier C. Celiac disease. N Engl J Med. 2007;1731–1743.25;357:.
  2. Rostom A, Murray JA, Kagnoff MF. American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease. Gastroenterology. 2006;131:1981–2002
  3. Talley NJ, Valdovinos M, Petterson TM, et al. Epidemiology of celiac sprue: a community-based study. Am J Gastroenterol. 1994;89:843–846
  4. Rossi TM, Albini CH, Kumar V. Incidence of celiac disease identified by the presence of serum endomysial antibodies in children with chronic diarrhea, short stature, or insulin-dependent diabetes mellitus. J Pediatr. 1993;123:262–264
  5. Catassi C. The world map of celiac disease. Acta Gastroenterol Latinoam. 2005;35:37–55
  6. Not T, Horvath K, Hill ID, et al. Celiac disease risk in the USA: high prevalence of antiendomysium antibodies in healthy blood donors. Scand J Gastroenterol. 1998;33:494–498
  7. Fasano A, Berti I, Gerarduzzi T, et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med. 2003;163:286–292
  8. Nielsen OH, Jacobsen O, Pedersen ER, et al. Non-tropical sprue: malignant diseases and mortality rate. Scand J Gastroenterol. 1985;20:13–18
  9. Logan RF, Rifkind EA, Turner ID, et al. Mortality in celiac disease. Gastroenterology. 1989;97:265–271
  10. Corrao G, Corazza GR, Bagnardi V, et al. Club del Tenue Study Group Mortality in patients with coeliac disease and their relatives: a cohort study. Lancet. 2001;358:356–361
  11. Collin P, Reunala T, Pukkala E, et al. Coeliac disease: associated disorders and survival. Gut. 1994;35:1215–1218
  12. Denny FW, Wannamaker LW, Brink WR, et al. Prevention of rheumatic fever; treatment of the preceding streptococcic infection. JAMA. 1950;143:151–153
  13. Thomas RJ, Conwill DE, Morton DE, et al. Penicillin prophylaxis for streptococcal infections in United States Navy and Marine Corps recruit camps, 1951–1985. Rev Infect Dis. 1988;10:125–130
  14. Seeff LB, Miller RN, Rabkin CS, et al. 45-Year follow-up of hepatitis C virus infection in healthy young adults. Ann Intern Med. 2000;132:105–111
  15. Kyle RA, Therneau TM, Rajkumar SV, et al. A long-term study of prognosis in monoclonal gammopathy of undetermined significance. N Engl J Med. 2002;346:564–569
  16. Chorzelski TP, Beutner EH, Sulej J, et al. IgA anti-endomysium antibody: a new immunological marker of dermatitis herpetiformis and coeliac disease. Br J Dermatol. 1984;111:395–402
  17. Aro P, Ronkainen J, Storskrubb T, et al. Valid symptom reporting at upper endoscopy in a random sample of the Swedish adult general population: the Kalixanda study. Scand J Gastroenterol. 2004;39:1280–1288
  18. Patterson BH, Bilgrad R. Use of the National Death Index in cancer studies. J Natl Cancer Inst. 1986;77:877–881
  19. Metzger MH, Heier M, Maki M, et al. Mortality excess in individuals with elevated IgA anti-transglutaminase antibodies: the KORA/MONICA Augsburg cohort study 1989–1998. Eur J Epidemiol. 2006;21:359–365
  20. Collin P. Should adults be screened for celiac disease? (What are the benefits and harms of screening?). Gastroenterology. 2005;128(4 Suppl 1):S104–S108
  21. Lohi S, Mustalahti K, Kaukinen K, et al. Increasing prevalence of coeliac disease over time. Aliment Pharmacol Ther. 2007;26:1217–1225
  22. Cabrera-Chavez F, Rouzaud-Sandez O, Sotelo-Cruz N, et al. Transglutaminase treatment of wheat and maize prolamins of bread increases the serum IgA reactivity of celiac disease patients. J Agric Food Chem. 2008;56:1387–1391
  23. Cronin CC, Shanahan F. Why is celiac disease so common in Ireland?. Perspect Biol Med. 2001;44:342–352
  24. Rautava S, Ruuskanen O, Ouwehand A, et al. The hygiene hypothesis of atopic disease: an extended version. J Pediatr Gastroenterol Nutr. 2004;38:378–388
  25. Kondrashova A, Mustalahti K, Kaukinen K, et al. Epivir Study Group Lower economic status and inferior hygienic environment may protect against celiac disease. Ann Med. 2008;40:223–231
  26. Stene LC, Honeyman MC, Hoffenberg EJ, et al. Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study. Am J Gastroenterol. 2006;101:2333–2340
  27. Murray JA, Van Dyke C, Plevak MF, et al. Trends in the identification and clinical features of celiac disease in a North American community, 1950-2001. Clin Gastroenterol Hepatol. 2003;1:19–27
  28. Ross SA. Nutritional genomic approaches to cancer prevention research. Exp Oncol. 2007;29:250–256
  29. Peracchi M, Trovato C, Longhi M, et al. Tissue transglutaminase antibodies in patients with end-stage heart failure. Am J Gastroenterol. 2002;97:2850–2854
  30. Snook JA, Dwyer L, Lee-Elliot C, et al. Adult coeliac disease and cigarette smoking. Gut. 1996;39:60–62
  31. Vazquez H, Smecuol E, Flores D, et al. Relation between cigarette smoking and celiac disease: evidence from a case-control study. Am J Gastroenterol. 2001;96:798–802
  32. Austin AS, Logan RF, Thomason K, et al. Cigarette smoking and adult coeliac disease. Scand J Gastroenterol. 2002;37:978–982
  33. Patel AH, Loftus EV, Murray JA, et al. Cigarette smoking and celiac sprue: a case-control study. Am J Gastroenterol. 2001;96:2388–2391

 This article has an accompanying continuing medical education activity on page 373. Learning Objective: Upon completion of this CME exercise, successful learners will be able to understand the potential impact of the changing prevalence of undiagnosed celiac disease in its potential effect on long-term outcome.

 Conflicts of interest The authors disclose no conflicts.

 Funding Supported in part by the National Institutes of Health (NIH) under Ruth L. Kirschstein National Research Service Award/Training Grant in Gastrointestinal Allergy and Immunology Research T32 AI07047 (A.R.-T.), NIH grants DK57892, DK070031, AR30582 (J.A.M.), DK61617 (W.R.K.), and CA62242 (R.A.K.), and the CTSA grant 1UL1RR024150-01 from the National Center for Research Resources.

PII: S0016-5085(09)00523-X

doi: 10.1053/j.gastro.2009.03.059

Gastroenterology
Volume 137, Issue 1 , Pages 88-93 , July 2009

Article Tools

* Image Usage & Resolution