Gastroenterology
Volume 137, Issue 1 , Pages 80-87.e1 , July 2009

Proton-Pump Inhibitor Therapy Induces Acid-Related Symptoms in Healthy Volunteers After Withdrawal of Therapy

  • Christina Reimer

      Affiliations

    • Department of Medical Gastroenterology, Køge University Hospital, Copenhagen University, Copenhagen, Denmark
    • ,
  • Bo Søndergaard

      Affiliations

    • Department of Medical Gastroenterology, Køge University Hospital, Copenhagen University, Copenhagen, Denmark
    • ,
  • Linda Hilsted

      Affiliations

    • Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    • ,
  • Peter Bytzer

      Affiliations

    • Department of Medical Gastroenterology, Køge University Hospital, Copenhagen University, Copenhagen, Denmark
    • Corresponding Author InformationReprint requests Peter Bytzer, MD, PhD, AGAF, Professor of Medicine, Copenhagen University, Køge University Hospital, Department of Medicine, Lykkebækvej 1, DK-4600 Køge, Denmark. fax: +45 5663 1552

Received 4 February 2009 ,Accepted 31 March 2009.

 Conflicts of interest The authors disclose the following: Peter Bytzer has consulted for and received honoraria and research funding from manufacturers of proton-pump inhibitors (AstraZeneca, Wyeth, Nycomed, Eisai). Bo Søndergaard has received honoraria from Wyeth. The remaining authors disclose no conflicts.

 Funding The study received funding through the Danish Medical Research Council, Københavns Amts Research Foundation and Region Sjællands Research Foundation. The medication and placebo was provided by AstraZeneca.

PII: S0016-5085(09)00522-8

doi: 10.1053/j.gastro.2009.03.058

Gastroenterology
Volume 137, Issue 1 , Pages 80-87.e1 , July 2009

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