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Gastroenterology
Volume 136, Issue 5
, Pages 1601-1608
, May 2009
Statins Are Associated With a Reduced Risk of Hepatocellular Carcinoma in a Large Cohort of Patients With Diabetes
References
- 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation. Atherosclerosis. 2002;161:17–26
- . Statin use and cancer risk in the General Practice Research Database. Br J Cancer. 2004;90:635–637
- Comparative effects of lovastatin on mammary and prostate oncogenesis in transgenic mouse models. Carcinogenesis. 2003;24:453–459
- HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis. Leukemia. 2002;16:508–519
- Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase. Proc Natl Acad Sci U S A. 1999;96:7797–7802
- . Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 2007;132:2557–2576
- EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer. Biochem Pharmacol. 2005;70:1568–1578
- Cell cycle arrest and apoptosis induction in hepatocellular carcinoma cells by HMG-CoA reductase inhibitors (Synergistic antiproliferative action with ligands of the peripheral benzodiazepine receptor). J Hepatol. 2005;43:808–816
- Pravastatin reduces lung metastasis of rat hepatocellular carcinoma via a coordinated decrease of MMP expression and activity. J Hepatol. 2007;46:69–76
- Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma (A randomized controlled trial). Br J Cancer. 2001;84:886–891
- Fluvastatin inhibits hepatitis C replication in humans. Am J Gastroenterol. 2008;
- Different anti-HCV profiles of statins and their potential for combination therapy with interferon. Hepatology. 2006;44:117–125
- Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation. Proc Natl Acad Sci U S A. 2003;100:15865–15870
- Preclinical evaluation of lovastatin. Am J Cardiol. 1988;62:16J–27J
- . Carcinogenicity of lipid-lowering drugs. JAMA. 1996;275:55–60
- Follow-up study of patients randomized in the Scandinavian simvastatin survival study (4S) of cholesterol lowering. Am J Cardiol. 2000;86:257–262
- Mortality and incidence of cancer during 10-year follow-up of the Scandinavian Simvastatin Survival Study (4S). Lancet. 2004;364:771–777
- . Do statins cause cancer? (A meta-analysis of large randomized clinical trials). Am J Med. 2001;110:716–723
- . Hepatotoxicity of hypolipidemic drugs. Clin Liver Dis. 2003;7:415–433
- The analysis of failure times in the presence of competing risks. Biometrics. 1978;34:541–554
- . Individual-level factors affecting enrollment in Medicare+choice plans and use of VA medical care by Medicare enrolled white, African American and Hispanic veterans. Final report for IIR 20-052: Medicare HMO enrollment and VA use by minority and low-income veterans. Department of Veterans Affairs, HSR&D Service; 2004;
- Methods to assess intended effects of drug treatment in observational studies are reviewed. J Clin Epidemiol. 2004;57:1223–1231
- 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway: implications for diabetic nephropathy. Proc Natl Acad Sci U S A. 2002;99:8301–8305
- . Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Arterioscler Thromb Vasc Biol. 2001;21:1712–1719
- Effect of simvastatin, an inhibitor of hydroxy-methylglutaryl coenzyme A reductase, on the growth of human Ito cells. Hepatology. 1994;20:1589–1594
- Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells. J Hepatol. 2003;38:564–572
- Validation of patient reports, automated pharmacy records, and pill counts with electronic monitoring of adherence to antihypertensive therapy. Med Care. 1999;37:846–857
- . The assessment of refill compliance using pharmacy records: methods, validity, and applications. J Clin Epidemiol. 1997;50:105–116
Conflicts of interest The authorsdisclose no conflicts.
Funding This research was supported in part by the Department of Veterans Affairs, Health Services Research and Development Service (IIR 02-081), and by a grant from the American College of Gastroenterology. Dr El–Serag is supported by a National Institutes of Health grant (K24DK078154-03).
PII: S0016-5085(09)00157-7
doi: 10.1053/j.gastro.2009.01.053
© 2009 AGA Institute. Published by Elsevier Inc. All rights reserved.
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Gastroenterology
Volume 136, Issue 5
, Pages 1601-1608
, May 2009

