Gastroenterology
Volume 136, Issue 2 , Pages 441-450.e1 , February 2009

Infliximab Prevents Crohn's Disease Recurrence After Ileal Resection

  • Miguel Regueiro

      Affiliations

    • Inflammatory Bowel Disease Center and Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    • Corresponding Author InformationAddress requests for reprints to: Miguel Regueiro, MD, Associate Professor of Medicine, University of Pittsburgh School of Medicine, Co-Director, Inflammatory Bowel Disease Center, Director, Gastroenterology, Hepatology, and Nutrition Fellowship Training Program, Division of Gastroenterology, Hepatology & Nutrition, University of Pittsburgh Medical Center, 200 Lothrop Street, PUH-C Wing Mezzanine Level, Pittsburgh, Pennsylvania 15213. fax: (412) 383-8913
    • ,
  • Wolfgang Schraut

      Affiliations

    • Inflammatory Bowel Disease Center and Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    • ,
  • Leonard Baidoo

      Affiliations

    • Inflammatory Bowel Disease Center and Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    • ,
  • Kevin E. Kip

      Affiliations

    • Research Center, University of South Florida, College of Nursing, Tampa, Florida
    • ,
  • Antonia R. Sepulveda

      Affiliations

    • Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
    • ,
  • Marilyn Pesci

      Affiliations

    • Inflammatory Bowel Disease Center and Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    • ,
  • Janet Harrison

      Affiliations

    • Inflammatory Bowel Disease Center and Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    • ,
  • Scott E. Plevy

      Affiliations

    • Inflammatory Bowel Disease Center and Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina

Received 3 September 2008 ,Accepted 23 October 2008.

  • Image Result

    Percentage of patients in remission (endoscopic grade score of i0 or i1) vs recurrence (endoscopic grade score of i2, i3, or i4) of Crohn's disease at the 1-year endoscopic evaluation by random assign

    Percentage of patients in remission (endoscopic grade score of i0 or i1) vs recurrence (endoscopic grade score of i2, i3, or i4) of Crohn's disease at the 1-year endoscopic evaluation by random assignment to infliximab or placebo. Infliximab vs placebo: P = .0006.

  • Image Result
    Endoscopic grade and percentage of patients with endoscopic recurrence of Crohn's disease at 1-year follow-up evaluation by random assignment to infliximab or placebo.

    Endoscopic grade and percentage of patients with endoscopic recurrence of Crohn's disease at 1-year follow-up evaluation by random assignment to infliximab or placebo.

  • Image Result
    CDAI scores of individual study patients at baseline and throughout the 1-year follow-up period by random assignment to (A) infliximab (n = 10) vs (B) placebo (n = 13). Two infliximab patients had the

    CDAI scores of individual study patients at baseline and throughout the 1-year follow-up period by random assignment to (A) infliximab (n = 10) vs (B) placebo (n = 13). Two infliximab patients had their last CDAI score carried forward beginning at weeks 30 and 46; 1 placebo patient had the last CDAI score carried forward beginning at week 36.

 The authors disclose no conflicts.

 This work was funded in part by an unrestricted grant from Centocor, Inc Miguel Regueiro, Scott Plevy, and Leonard Baidoo participate or participated as a consultant or speaker for Centocor, Inc.

 Registered with www.clinicaltrials.gov (NCT00688636).

PII: S0016-5085(08)01889-1

doi: 10.1053/j.gastro.2008.10.051

Gastroenterology
Volume 136, Issue 2 , Pages 441-450.e1 , February 2009

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