Gastroenterology
Volume 136, Issue 2 , Pages 496-504.e3 , February 2009

Peginterferon Alfa-2a Plus Ribavirin for the Treatment of Dual Chronic Infection With Hepatitis B and C Viruses

Interim results of this trial were presented at the 49th International Association for the Study of the Liver meeting, September 7–11, 2006, Cairo, Egypt; at the 42nd European Association for the Study of the Liver meeting, April 11–15, 2007, Barcelona, Spain; at the 58th American Association for the Study of the Liver Meeting, November 1–5, 2007, Boston, MA; at the 17th Asian Pacific Association for the Study of the Liver meeting, March 25–28, 2007, Kyoto, Japan; at the 18th Asian Pacific Association for the Study of the Liver meeting, March 23–26, 2008, Seoul, South Korea; and at the 43rd European Association for the Study of the Liver meeting, April 23–27, 2008, Milan, Italy.

  • Chun–Jen Liu

      Affiliations

    • National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Wan–Long Chuang

      Affiliations

    • Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • ,
  • Chuan–Mo Lee

      Affiliations

    • Chang Gung Memorial Hospital-Kaohsiung, Kaohsiung, Taiwan
    • ,
  • Ming–Lung Yu

      Affiliations

    • Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • ,
  • Sheng–Nan Lu

      Affiliations

    • Chang Gung Memorial Hospital-Kaohsiung, Kaohsiung, Taiwan
    • ,
  • Shun–Sheng Wu

      Affiliations

    • Changhua Christian Hospital, Changhua, Taiwan
    • ,
  • Li–Ying Liao

      Affiliations

    • Taipei City Hospital, Ren-Ai Branch, Taipei, Taiwan
    • ,
  • Chi–Ling Chen

      Affiliations

    • National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Hsing–Tao Kuo

      Affiliations

    • Chi Mei Medical Center, Tainan, Taiwan
    • ,
  • You–Chen Chao

      Affiliations

    • Tri-Service General Hospital, Taipei, Taiwan
    • ,
  • Shui–Yi Tung

      Affiliations

    • Chia-Yi Chang Gung Memorial Hospital, Chiayi Hsien, Taiwan
    • ,
  • Sien–Sing Yang

      Affiliations

    • Cathay General Hospital, Taipei, Taiwan
    • ,
  • Jia–Horng Kao

      Affiliations

    • National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Chen–Hua Liu

      Affiliations

    • National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Wei–Wen Su

      Affiliations

    • Changhua Christian Hospital, Changhua, Taiwan
    • ,
  • Chih–Lin Lin

      Affiliations

    • Taipei City Hospital, Ren-Ai Branch, Taipei, Taiwan
    • ,
  • Yung–Ming Jeng

      Affiliations

    • National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Pei–Jer Chen

      Affiliations

    • National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Ding–Shinn Chen

      Affiliations

    • National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
    • Corresponding Author InformationAddress requests for reprints to: Ding–Shinn Chen, MD, Distinguished Chair Professor, Department of Internal Medicine, National Taiwan University College of Medicine, 1 Chang-Te Street, Taipei 10002, Taiwan. fax: (886) 2-23317624

Received 16 July 2008 ,Accepted 23 October 2008.

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 The statistical analysis of the entire data sets pertaining to efficacy and safety was performed independently by a biostatistician (C.–L. Chen, National Taiwan University College of Medicine) who is not employed by the corporate entity.

 The corresponding authors (D.–S. Chen and P.–J. Chen) had full access to all of the data and take full responsibility for the veracity of the data and analysis. The study sponsors did not play any role in the study design; in the collection, analysis, and interpretation of data; and in the decision to submit the report for publication.

 US National Institutes of Health registration number for clinical trial: NCT00361179. An Open Label, Comparative, Multi-Center Study, To Evaluate the Efficacy and Safety of Peginterferon Alfa-2a Plus Ribavirin in the Treatment of Patients With Chronic Hepatitis C/Hepatitis B Co-Infection and Chronic Hepatitis C.

 The authors disclose the following: This study was supported in part by grants from the Department of Health, the National Science Council, Executive Yuan, Taiwan; National Taiwan University; and National Health Research Institutes, Taiwan.

PII: S0016-5085(08)01887-8

doi: 10.1053/j.gastro.2008.10.049

Gastroenterology
Volume 136, Issue 2 , Pages 496-504.e3 , February 2009

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