Gastroenterology
Volume 136, Issue 1 , Pages 138-148, January 2009

Incidence of Hepatocellular Carcinoma and Associated Risk Factors in Hepatitis C-Related Advanced Liver Disease

  • Anna S. Lok

      Affiliations

    • Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan
    • Corresponding Author InformationAddress requests for reprints to: Anna S. Lok, MD, Division of Gastroenterology, University of Michigan Hospitals, 3912 Taubman Center, SPC 5362, Ann Arbor, Michigan 48109. fax: (734) 936-7392
    • ,
  • Leonard B. Seeff

      Affiliations

    • Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland
    • ,
  • Timothy R. Morgan

      Affiliations

    • Division of Gastroenterology, University of California-Irvine, Irvine, California, and Gastroenterology Service, VA Long Beach Healthcare System, Long Beach, California
    • ,
  • Adrian M. di Bisceglie

      Affiliations

    • Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St. Louis, Missouri
    • ,
  • Richard K. Sterling

      Affiliations

    • Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, Virginia
    • ,
  • Teresa M. Curto

      Affiliations

    • New England Research Institutes, Watertown, Massachusetts
    • ,
  • Gregory T. Everson

      Affiliations

    • Section of Hepatology, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Denver, Colorado
    • ,
  • Karen L. Lindsay

      Affiliations

    • Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, California
    • ,
  • William M. Lee

      Affiliations

    • Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, Texas
    • ,
  • Herbert L. Bonkovsky

      Affiliations

    • Departments of Medicine and Molecular & Structural Biology and The Liver-Biliary-Pancreatic Center, University of Connecticut Health Center, Farmington, Connecticut
    • ,
  • Jules L. Dienstag

      Affiliations

    • Gastrointestinal Unit (Medical Services), Massachusetts General Hospital and the Department of Medicine, Harvard Medical School, Boston, Massachusetts
    • ,
  • Marc G. Ghany

      Affiliations

    • Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland
    • ,
  • Chihiro Morishima

      Affiliations

    • Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, Washington, DC
    • ,
  • Zachary D. Goodman

      Affiliations

    • Division of Hepatic Pathology and the Veterans Administration Special Reference Laboratory for Pathology, Armed Forces Institute of Pathology, Washington, DC
    • ,
  • HALT-C Trial Group

Received 27 May 2008; accepted 11 September 2008. published online 19 September 2008.

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 H.L.B.'s current address is Carolinas Medical Center, Charlotte, North Carolina.

 The authors disclose the following: Financial relationships of the authors with Hoffmann–La Roche, Inc, are as follows: A. S. Lok is a consultant; T. R. Morgan is a consultant, on the speaker's bureau, and receives research support; A. M. Di Bisceglie is a consultant, on the speaker's bureau, and receives research support; R. K. Sterling is a consultant, on the speaker's bureau, and receives research support; G. T. Everson is a consultant, on the speaker's bureau, and receives research support; K. L. Lindsay is a consultant and receives research support; W. M. Lee receives research support; H. L. Bonkovsky receives research support. Authors with no financial relationships related to this project are L. B. Seeff, T. M. Curto, J. L. Dienstag, M. G. Ghany, C. Morishima, and Z. D. Goodman. Potential investigator conflict of interest was disclosed to study participants.

 Supported by the National Institute of Diabetes and Digestive and Kidney Diseases (contract numbers are listed in Appendix 1); the National Institute of Allergy and Infectious Diseases (NIAID); the National Cancer Institute; the National Center for Minority Health and Health Disparities; General Clinical Research Center grants from the National Center for Research Resources, National Institutes of Health (grant numbers are listed in Appendix 1); and by Hoffman–La Roche, Inc, through a Cooperative Research and Development Agreement (CRADA) with the National Institutes of Health.

 This is publication No. 34 from the HALT-C Trial Group.

 The HALT-C Trial was registered with clinicaltrials.gov (NCT00006164).

PII: S0016-5085(08)01679-X

doi:10.1053/j.gastro.2008.09.014

Gastroenterology
Volume 136, Issue 1 , Pages 138-148, January 2009

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