Gastroenterology
Volume 135, Issue 2 , Pages 621-631.e8 , August 2008

Hedgehog Signaling Is Required for Effective Regeneration of Exocrine Pancreas

  • Volker Fendrich

      Affiliations

    • Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland
    • Department of Surgery, Philipps-University Marburg, Marburg, Germany
    • ,
  • Farzad Esni

      Affiliations

    • Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania
    • ,
  • Maria Veronica R. Garay

      Affiliations

    • Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado
    • ,
  • Georg Feldmann

      Affiliations

    • Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland
    • ,
  • Nils Habbe

      Affiliations

    • Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland
    • ,
  • Jan Nygaard Jensen

      Affiliations

    • Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado
    • ,
  • Yuval Dor

      Affiliations

    • Department of Cellular Biochemistry and Human Genetics, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
    • ,
  • Doris Stoffers

      Affiliations

    • Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Jan Jensen

      Affiliations

    • Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado
    • ,
  • Steven D. Leach

      Affiliations

    • Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland
    • The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland
    • Corresponding Author InformationAddress requests for reprints to: Anirban Maitra, MBBS, Associate Professor of Pathology and Oncology, The Sol Goldman Pancreatic Cancer Research Center, CRB-2, Suite 345, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, Maryland 21231. fax: (410) 614 0671 or Steven D. Leach, MD, Professor of Surgery, Oncology, and Cell Biology; The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 600 N. Wolfe St/Osler 603, Baltimore, Maryland 21287. fax: (410) 614 2913.
    • ,
  • Anirban Maitra

      Affiliations

    • Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland
    • The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland
    • Corresponding Author InformationAddress requests for reprints to: Anirban Maitra, MBBS, Associate Professor of Pathology and Oncology, The Sol Goldman Pancreatic Cancer Research Center, CRB-2, Suite 345, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, Maryland 21231. fax: (410) 614 0671 or Steven D. Leach, MD, Professor of Surgery, Oncology, and Cell Biology; The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 600 N. Wolfe St/Osler 603, Baltimore, Maryland 21287. fax: (410) 614 2913.

Received 4 July 2007 ,Accepted 10 April 2008.

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 Supported by NIH grants CA113669 and DK072532 and the Sol Goldman Pancreatic Cancer Research Center (to A.M.); NIH grants DK61215 and DK56211 and the Paul Neumann Professorship in Pancreatic Cancer Research (to S.D.L.); a fellowship grant within the Postdoctoral Program of the German Academic Exchange Service (DAAD; to G.F.); the Barbara S. Goodman Pancreatic Cancer Career Development Award of the Israel Cancer Research Fund (to Y.D.); and, for mouse husbandry costs, by funds from a Mouse Models of Human Cancer Consortium grant to Robert J. Coffey at Vanderbilt University (U01CA084239).

 Conflicts of interest: The authors declare no competing financial conflicts of interest.

 V.F. and F.E. contributed equally to this work.

 The S.D.L. and A.M. laboratories contributed equally to this work.

 J.J.'s present address is Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.

PII: S0016-5085(08)00640-9

doi: 10.1053/j.gastro.2008.04.011

Gastroenterology
Volume 135, Issue 2 , Pages 621-631.e8 , August 2008

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