Gastroenterology
Volume 135, Issue 1 , Pages 100-110, July 2008

Rosiglitazone for Nonalcoholic Steatohepatitis: One-Year Results of the Randomized Placebo-Controlled Fatty Liver Improvement With Rosiglitazone Therapy (FLIRT) Trial

  • Vlad Ratziu

      Affiliations

    • Université Pierre et Marie Curie Paris VI, Assistance Publique-Hôpitaux de Paris, Service d'Hépatogastroentérologie, Paris, France
    • Corresponding Author InformationAddress requests for reprints to: Prof Vlad Ratziu, Hôpital Pitié-Salpetriére, 47-83 Bd de l'Hôpital, Paris, France. fax: (33) 1 42 16 10 49.
    • ,
  • Philippe Giral

      Affiliations

    • INSERM UMRS_893, CdR Saint-Antoine, Paris, France
    • ,
  • Sophie Jacqueminet

      Affiliations

    • Université Pierre et Marie Curie Paris VI, Assistance Publique-Hôpitaux de Paris, Service d'Endocrinologie, Paris, France
    • ,
  • Fréderic Charlotte

      Affiliations

    • Université Pierre et Marie Curie Paris VI, Assistance Publique-Hôpitaux de Paris, Service de Diabétologie, Paris, France
    • ,
  • Agnès Hartemann–Heurtier

      Affiliations

    • Université Pierre et Marie Curie Paris VI, Assistance Publique-Hôpitaux de Paris, Service d'Endocrinologie, Paris, France
    • ,
  • Lawrence Serfaty

      Affiliations

    • Laboratoire d'Anatomie Pathologique, Hôpital Pitié-Salpêtrière, Paris, France
    • ,
  • Philippe Podevin

      Affiliations

    • Assistance Publique-Hôpitaux de Paris, Service d'Hépatologie, Hôpital Saint-Antoine, Paris, France
    • ,
  • Jean–Marc Lacorte

      Affiliations

    • Fédération de Biochimie, Hôpital Pitié-Salpêtrière, Paris, France
    • ,
  • Carole Bernhardt

      Affiliations

    • Université Pierre et Marie Curie Paris VI, Assistance Publique-Hôpitaux de Paris, Service d'Hépatogastroentérologie, Paris, France
    • ,
  • Eric Bruckert

      Affiliations

    • INSERM UMRS_893, CdR Saint-Antoine, Paris, France
    • ,
  • André Grimaldi

      Affiliations

    • Université Pierre et Marie Curie Paris VI, Assistance Publique-Hôpitaux de Paris, Service d'Endocrinologie, Paris, France
    • ,
  • Thierry Poynard

      Affiliations

    • Université Pierre et Marie Curie Paris VI, Assistance Publique-Hôpitaux de Paris, Service d'Hépatogastroentérologie, Paris, France
    • ,
  • LIDO Study Group

Received 13 November 2007; accepted 20 March 2008. published online 09 April 2008.

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 This was an investigator-initiated trial, and GlaxoSmithKline Pharmaceuticals had no direct or indirect involvement in the design of the trial, data collection, or preparation or submission of the manuscript. GlaxoSmithKline provided rosiglitazone and placebo for this trial and partly funded the trial. None of the authors have a personal conflict of interest with the manufacturer of any of the marketed thiazolidinediones. V.R. is a consultant to Astellas, Gilead, Pfizer, Sanofi-Aventis, and Trophos. T.P. is a consultant for and owns 15% of BioPredictive, a company that markets FibroTest and SteatoTest.

 The members of the Liver Injury in Diabetes and Obesity (LIDO) Study Group are as follows: André Grimaldi, Philippe Giral, Eric Bruckert, Arnaud Basdevant, Karine Clement, Agnès Hartemann-Heurtier, Sophie Gombert, Francine Lamaison, Dominique Simon, Joseph Moussalli, Pascal Lebray, Christiane Coussieu, Djamila Messous, Françoise Imbert-Bismut, Yves Benhamou, Cecilia D'Arrondel, Carole Bernhardt, Isabelle Ravalet, Hôpital Pitié-Salpêtrière; Philippe Podevin, Hôpital Cochin; Christian Boitard, Etienne Larger, Hôpital Hotel-Dieu; Lawrence Serfaty, Chantal Housset, Jacqueline Capeau, Hôpital Saint Antoine, all in Paris, France..

PII: S0016-5085(08)00630-6

doi:10.1053/j.gastro.2008.03.078

Gastroenterology
Volume 135, Issue 1 , Pages 100-110, July 2008

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