Gastroenterology
Volume 134, Issue 1 , Pages 346-348 , January 2008

Life in the Gut Without Oxygen: Adaptive Mechanisms and Inflammatory Bowel Disease

  • Anthony T. Blikslager

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to: Anthony T. Blikslager, MD, Department of Clinical Sciences, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606.

References 

  1. Shepherd AP. Local control of intestinal oxygenation and blood flow. Annu Rev Physiol. 1982;44:13–27
  2. Sartor RB. Innate immunity in the pathogenesis and therapy of IBD. J Gastroenterol. 2003;38:43–47
  3. Sartor RB, Blumberg RS, Braun J, et al. CCFA microbial-host interactions workshop: highlights and key observations. Inflamm Bowel Dis. 2007;13:600–619
  4. Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature. 2007;448:427–434
  5. Robinson A, Keely S, Karhausen J, et al. Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology. 2008;134:145–155
  6. Karthausen J, Haase VH, Colgan SP. Inflammatory hypoxia: role of hypoxia-inducible factor. Cell Cycle. 2005;4:256–258
  7. Kong T, Westerman KA, Faigle M, et al. HIF-dependent induction of adenosine A2B receptor in hypoxia. FASEB J. 2006;20:2242–2250
  8. Cummins EP, Seeballuck F, Keely SJ, et al. The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis. Gastroenterology. 2008;134:156–165
  9. Baregamian N, Rychahou PG, Hawkins HK, et al. Phosphatidylinositol 3-kinase pathway regulates hypoxia-inducible factor-1 to protect from intestinal injury during necrotizing enterocolitis. Surgery. 2007;142:295–302
  10. Utech M, Brüwer M, Nusrat A. Tight junctions and cell-cell interactions. Methods Mol Biol. 2006;341:185–195
  11. Kim SC, Tonkonogy SL, Albright CA, et al. Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria. Gastroenterology. 2005;128:891–906
  12. Rath HC, Wilson KH, Sartor RB. Differential induction of colitis and gastritis in HLA-B27 transgenic rats selectively colonized with Bacteroides vulgatus or Escherichia coli. Infect Immun. 1999;67:2969–2974
  13. Yen TH, Wright NA. The gastrointestinal tract stem cell niche. Stem Cell Rev. 2006;2:203–212
  14. Bullen TF, Forrest S, Campbell F, et al. Characterization of epithelial cell shedding from human small intestine. Lab Invest. 2006;86:1052–1063

PII: S0016-5085(07)02126-9

doi: 10.1053/j.gastro.2007.11.049

Gastroenterology
Volume 134, Issue 1 , Pages 346-348 , January 2008

Article Tools

* Image Usage & Resolution