Gastroenterology
Volume 133, Issue 5 , Pages 1423-1429 , November 2007

Elevated Serum Concentrations of Insulin and Glucose Increase Risk of Recurrent Colorectal Adenomas

  • Andrew Flood

      Affiliations

    • Division of Epidemiology and Community Health and the Cancer Center, University of Minnesota, Minneapolis, Minnesota
    • Corresponding Author InformationAddress requests for reprints to: Andrew Flood, PhD, Division of Epidemiology and Community Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, Minnesota 55454. fax: (612) 624-0315.
    • ,
  • Volker Mai

      Affiliations

    • University of Maryland School of Medicine, Baltimore, Maryland
    • ,
  • Ruth Pfeiffer

      Affiliations

    • Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland
    • ,
  • Lisa Kahle

      Affiliations

    • Information Management Services, Inc, Silver Spring, Maryland
    • ,
  • Alan T. Remaley

      Affiliations

    • Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland
    • ,
  • Elaine Lanza

      Affiliations

    • Center for Cancer Research, National Cancer Institute, Bethesda, Maryland
    • ,
  • Arthur Schatzkin

      Affiliations

    • Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland

Received 17 May 2007 ,Accepted 2 August 2007.

References 

  1. Giovannucci E. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J Nutr. 2001;131:3109S–3120S
  2. Sandhu MS, Dunger DB, Giovannucci EL. Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. J Natl Cancer Inst. 2002;94:972–980
  3. Giovannucci E. Insulin and colon cancer. Cancer Causes Control. 1995;6:164–179
  4. McKeown-Eyssen G. Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk?. Cancer Epidemiol Biomarkers Prev. 1994;3:687–695
  5. Kaaks R. Nutrition, energy balance and colon cancer risk: the role of insulin and insulin-like growth factor-I. IARC Sci Publ. 2002;156:289–293
  6. Pollak MN, Schernhammer ES, Hankinson SE. Insulin-like growth factors and neoplasia. Nat Rev Cancer. 2004;4:505–518
  7. Pollak M. Insulin-like growth factor physiology and cancer risk. Eur J Cancer. 2000;36:1224–1228
  8. Rolo AP, Palmeira CM. Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. Toxicol Appl Pharmacol. 2006;212:167–178
  9. Schatzkin A, Lanza E, Corle D, et al. Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas (Polyp Prevention Trial Study Group). N Engl J Med. 2000;342:1149–1155
  10. Ahmed RL, Schmitz KH, Anderson KE, et al. The metabolic syndrome and risk of incident colorectal cancer. Cancer. 2006;107:28–36
  11. Colangelo LA, Gapstur SM, Gann PH, et al. Colorectal cancer mortality and factors related to the insulin resistance syndrome. Cancer Epidemiol Biomarkers Prev. 2002;11:385–391
  12. Jee SH, Ohrr H, Sull JW, et al. Fasting serum glucose level and cancer risk in Korean men and women. JAMA. 2005;293:194–202
  13. Limburg PJ, Stolzenberg-Solomon RZ, Vierkant RA, et al. Insulin, glucose, insulin resistance, and incident colorectal cancer in male smokers. Clin Gastroenterol Hepatol. 2006;4:1514–1521
  14. Nilsen TI, Vatten LJ. Prospective study of colorectal cancer risk and physical activity, diabetes, blood glucose and BMI: exploring the hyperinsulinaemia hypothesis. Br J Cancer. 2001;84:417–422
  15. Platz EA, Hankinson SE, Rifai N, et al. Glycosylated hemoglobin and risk of colorectal cancer and adenoma. Cancer Causes Control. 1999;10:379–386(United States)
  16. Saydah SH, Platz EA, Rifai N, et al. Association of markers of insulin and glucose control with subsequent colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2003;12:412–418
  17. Schoen RE, Tangen CM, Kuller LH, et al. Increased blood glucose and insulin, body size, and incident colorectal cancer. J Natl Cancer Inst. 1999;91:1147–1154
  18. Trevisan M, Liu J, Muti P, et al. Markers of insulin resistance and colorectal cancer mortality. Cancer Epidemiol Biomarkers Prev. 2001;10:937–941
  19. Tsushima M, Nomura AM, Lee J, et al. Prospective study of the association of serum triglyceride and glucose with colorectal cancer. Dig Dis Sci. 2005;50:499–505
  20. Wei EK, Ma J, Pollak MN, et al. A prospective study of C-peptide, insulin-like growth factor-I, insulin-like growth factor binding protein-1, and the risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev. 2005;14:850–855
  21. Wei EK, Ma J, Pollak MN, et al. C-peptide, insulin-like growth factor binding protein-1, glycosylated hemoglobin, and the risk of distal colorectal adenoma in women. Cancer Epidemiol Biomarkers Prev. 2006;15:750–755
  22. Palmqvist R, Stattin P, Rinaldi S, et al. Plasma insulin, IGF-binding proteins-1 and -2 and risk of colorectal cancer: a prospective study in northern Sweden. Int J Cancer. 2003;107:89–93
  23. Otani T, Iwasaki M, Sasazuki S, et al. Plasma C-peptide, insulin-like growth factor-I, insulin-like growth factor binding proteins and risk of colorectal cancer in a nested case-control study: the Japan public health center-based prospective study. Int J Cancer. 2007;20:2007–2012
  24. Kaaks R, Toniolo P, Akhmedkhanov A, et al. Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women. J Natl Cancer Inst. 2000;92:1592–1600
  25. Larsen PR, Kronenberg HM, Melmed S, et al. Williams textbook of endocrinology. Philadelphia: Saunders; 2003;

 Supported by the National Institutes of Health (grant K07 CA108910-01A1) and by Intramural Research Program funds from the National Cancer Institute (Bethesda, MD).

PII: S0016-5085(07)01496-5

doi: 10.1053/j.gastro.2007.08.040

Gastroenterology
Volume 133, Issue 5 , Pages 1423-1429 , November 2007

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