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Gastroenterology
Volume 133, Issue 4
, Pages 1342-1363
, October 2007
Eosinophilic Esophagitis in Children and Adults: A Systematic Review and Consensus Recommendations for Diagnosis and Treatment: Sponsored by the American Gastroenterological Association (AGA) Institute and North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition
References
- . Reflux esophagitis: sequelae and differential diagnosis in infants and children including eosinophilic esophagitis. Pediatr Dev Pathol. 2004;7:5–16
- Eosinophils in the esophagus—peptic or allergic eosinophilic esophagitis? (Case series of three patients with esophageal eosinophilia). Am J Gastroenterol. 2006;101:1666–1670
- Idiopathic eosinophilic esophagitis in adults: the ringed esophagus. Radiology. 2005;236:159–165
- Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years. Gastroenterology. 2003;125:1660–1669
- Cytokine expression in healthy and inflamed mucosa: probing the role of eosinophils in the digestive tract. Inflamm Bowel Dis. 2005;11:720–726
- Eosinophilic esophagitis in adults: clinical, endoscopic, histologic findings, and response to treatment with fluticasone propionate. Gastrointest Endosc. 2006;63:3–12
- Eosinophilic esophagitis in adults: an emerging problem with unique esophageal features. Gastrointest Endosc. 2004;59:355–361
- Eosinophilic esophagitis in adults: distinguishing features from gastroesophageal reflux disease: a study of 41 patients. Mod Pathol. 2006;19:90–96
- Endoscopy in eosinophilic esophagitis: “feline” esophagus and perforation risk. Clin Gastroenterol Hepatol. 2003;1:433–437
- Association of eosinophilic inflammation with esophageal food impaction in adults. Gastrointest Endosc. 2005;61:795–801
- Clinical and endoscopic features of eosinophilic esophagitis in adults. Gastrointest Endosc. 2003;58:516–522
- Clinical presentation of patients with eosinophilic inflammation of the esophagus. Gastrointest Endosc. 2006;64:473–478
- Eosinophilic oesophagitis: a novel treatment using Montelukast. Gut. 2003;52:181–185
- Esophageal eosinophilia with dysphagia (A distinct clinicopathologic syndrome). Dig Dis Sci. 1993;38:109–116
- . Topical corticosteroid treatment of dysphagia due to eosinophilic esophagitis in adults. Mayo Clin Proc. 2003;78:830–835
- Allergic esophagitis in children—a clinicopathological entity. Am J Surg Pathol. 1999;23:390–396
- Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionate. Gastroenterology. 2002;122:1216–1225
- Correlation between number of eosinophils and reflux index on same day esophageal biopsy and 24 hour esophageal pH monitoring. Am J Gastroenterol. 2004;99:801–805
- Eosinophilic esophagitis in children: symptoms, histology, and pH probe results. J Pediatr Gastroenterol Nutr. 2004;39:373–377
- The spectrum of pediatric eosinophilic esophagitis beyond infancy: a clinical series of 30 children. Am J Gastroenterol. 2000;95:1422–1430
- Clinical and immunopathologic effects of swallowed fluticasone for eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2004;2:568–575
- Eosinophilic esophagitis: a 10-year experience in 381 children. Clin Gastroenterol Hepatol. 2005;3:1198–1206
- Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula. Gastroenterology. 1995;109:1503–1512
- Cytokine expression in normal and inflamed esophageal mucosa: a study into the pathogenesis of allergic eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2006;42:22–26
- High-resolution EUS in children with eosinophilic “allergic” esophagitis. Gastrointest Endosc. 2003;57:30–36
- Long-term follow-up of symptoms and peripheral eosinophil counts in seven children with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2004;38:452–456
- Paediatric eosinophilic oesophagitis: towards early diagnosis and best treatment. Dig Liver Dis. 2006;38:245–251
- Esophageal eosinophilia in children with dysphagia. J Pediatr Gastroenterol Nutr. 2003;37:498–503
- Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. J Clin Invest. 2006;116:536–547
- Cysteinyl leukotriene levels in esophageal mucosal biopsies of children with eosinophilic inflammation: are they all the same?. Am J Gastroenterol. 2006;101:1125–1128
- Eosinophilic esophagitis: its role in aerodigestive tract disorders. Otolaryngol Clin North Am. 2006;39:205–221
- . Eosinophilic esophagitis. N Engl J Med. 2004;351:940–941
- . Eosinophilic esophagitis: escalating epidemiology?. J Allergy Clin Immunol. 2005;115:418–419
- . Three brothers with dysphagia caused by eosinophilic esophagitis. Gastrointest Endosc. 2005;61:165–167
- . Eosinophilic esophagitis in a father and a daughter. Gastrointest Endosc. 2005;61:932
- Fragility of the esophageal mucosa: a pathognomonic endoscopic sign of primary eosinophilic esophagitis?. Gastrointest Endosc. 2003;57:407–412
- Eosinophilic oesophagitis: an emerging important cause for undiagnosed dysphagia. N Z Med J. 2006;119:U1889
- The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101:1900–1920
- The small-caliber esophagus: an unappreciated cause of dysphagia for solids in patients with eosinophilic esophagitis. Gastrointest Endosc. 2002;55:99–106
- Adherent white plaques: an endoscopic finding in eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2004;38:208–212
- Eosinophilic esophagitis: red on microscopy, white on endoscopy. Digestion. 2004;70:109–116
- Multiple esophageal rings: an association with eosinophilic esophagitis: case report and review of the literature. Am J Gastroenterol. 2000;95:1572–1575
- Association of Schatzki ring with eosinophilic esophagitis in children. J Pediatr Gastroenterol Nutr. 2004;38:436–441
- Eosinophilic esophagitis in adults, an emerging cause of dysphagia (Description of 9 cases). Rev Esp Enferm Dig. 2005;97:229–239
- White specks in the esophageal mucosa: an endoscopic manifestation of non-reflux eosinophilic esophagitis in children. Gastrointest Endosc. 2004;59:835–838
- . “Congenital” esophageal stenosis, corrugated ringed esophagus, and eosinophilic esophagitis. Am J Gastroenterol. 2000;95:2123–2124
- Eosinophilic esophagitis: strictures, impactions, dysphagia. Dig Dis Sci. 2003;48:22–29
- Vertical lines in distal esophageal mucosa (VLEM): a true endoscopic manifestation of esophagitis in children?. Gastrointest Endosc. 1997;45:485–489
- . A novel endoscopic appearance of idiopathic eosinophilic esophagitis. Endoscopy. 2000;32:S33
- The ringed esophagus: histological features of GERD. Am J Gastroenterol. 2001;96:984–989
- Idiopathic eosinophilic esophagitis is associated with a T(H)2-type allergic inflammatory response. J Allergy Clin Immunol. 2001;108:954–961
- . Severity of basal cell hyperplasia differs in reflux versus eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2006;42:506–509
- . The use of patch testing in the diagnosis of food allergy. Curr Allergy Asthma Rep. 2005;5:86–90
- Severity of esophageal eosinophilia predicts response to conventional gastroesophageal reflux therapy. Pediatr Develop Pathol. 1999;2:15–18
- Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents. Am J Gastroenterol. 2003;98:777–782
- Primary eosinophilic esophagitis in children: successful treatment with oral corticosteroids. J Pediatr Gastroenterol Nutr. 1998;26:380–385
- Histopathologic variability and endoscopic correlates in adults with eosinophilic esophagitis. Gastrointest Endosc. 2006;64:313–319
- Idiopathic eosinophilic esophagitis. Radiology. 1993;186:789–793
- . Radiographic abnormalities in eosinophilic esophagitis. Gastrointest Radiol. 1985;10:321–324
- . Eosinophilic gastroenteritis with esophageal involvement. Gastroenterology. 1977;72:1312–1316
- . Eosinophilic esophagitis. AJR Am J Roentgenol. 1981;136:1001–1003
- Eosinophilic esophagitis, a rare manifestation of eosinophilic gastroenteritis. Schweiz Med Wochenschr. 1982;112:731–734
- . Esophageal involvement in eosinophilic gastroenteritis. Pediatr Radiol. 1983;13:35–38
- . Eosinophilic esophagitis in a patient with vigorous achalasia. Gastroenterology. 1978;74:1298–1301
- Intraepithelial eosinophils: a new diagnostic criterion for reflux esophagitis. Gastroenterology. 1982;83:818–823
- Esophagitis: a frequent consequence of gastroesophageal reflux in infancy. J Pediatr. 1985;107:881–884
- . Esophageal biopsy in the diagnosis of reflux esophagitis. J Pediatr Surg. 1981;16:379–384
- . Clinical and laboratory correlates of esophagitis in young children. J Pediatr Gastroenterol Nutr. 1988;7:52–56
- . Intraepithelial eosinophils in endoscopic biopsies of adults with reflux esophagitis. Am J Surg Pathol. 1984;8:899–905
- . Marked eosinophilia in esophageal mucosal biopsies. Am J Surg Pathol. 1985;9:475–479
- Radiographic manifestations of eosinophilic gastroenteritis. Abdom Imaging. 1995;20:406–413
- Treatment of eosinophilic esophagitis with inhaled corticosteroids. J Pediatr Gastroenterol Nutr. 1998;27:90–93
- Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests. Ann Allergy Asthma Immunol. 2005;95:336–343
- Eosinophil infiltration and degranulation in normal human tissues: evidence for eosinophil degranulation in normal gastrointestinal tract. Int Arch Allergy Immunol. 2001;125(Suppl 1):55–58
- Quantity and distribution of eosinophils in the gastrointestinal tract of children. Pediatr Dev Pathol. 2006;9:210–218
- . Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism. Gastroenterology. 2003;125:1419–1427
- IL-5 promotes eosinophil trafficking to the esophagus. J Immunol. 2002;168:2464–2469
- Epicutaneous antigen exposure primes for experimental eosinophilic esophagitis in mice. Gastroenterology. 2005;129:985–994
- An etiological role for aeroallergens and eosinophils in experimental esophagitis. J Clin Invest. 2001;107:83–90
- Eosinophil infiltration of the oesophageal mucosa in patients with pollen allergy during the season. Clin Exp Allergy. 2005;35:1423–1431
- . Pollen and eosinophilic esophagitis. J Allergy Clin Immunol. 2003;112:796–797
- Potential of blood eosinophils, eosinophil-derived neurotoxin, and eotaxin-3 as biomarkers of eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2006;4:1328–1336
- Eosinophilic esophagitis is frequently associated with IgE-mediated allergic airway diseases. J Allergy Clin Immunol. 2005;115:1090–1092
- . Allergic eosinophilic esophagitis. Indian J Pediatr. 2006;73:919–925
- Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2006;4:1097–1102
- . Some results of patch tests. Arch Dermatol. 1937;35:433
- Basophils in allergen-induced patch test sites in atopic dermatitis. Lancet. 1982;1:127
- . Airborne and dietary allergens in atopic eczema: a comprehensive review of diagnostic tests. J Exp Dermatol. 2000;25:544
- . Atopic dermatitis. Lancet. 2003;361:151
- A pilot study of the usefulness and safety of a ready-to-use atopy patch test (Diallertest) versus a comparator (Finn Chamber) during cow’s milk allergy in children. J Allergy Clin Immunol. 2005;116:1321–1326
- . Combined skin prick and patch testing enhances identification of food allergy in infants with atopic dermatitis. J Allergy Clin Immunol. 1996;97:9–15
- Altered expression of IgG and complement receptors indicates a significant role of phagocytes in atopic dermatitis. J Allergy Clin Immunol. 1997;99:707–713
- The use of skin prick tests and patch tests to identify causative foods in eosinophilic esophagitis. J Allergy Clin Immunol. 2002;109:363–368
- . What is the optimal occlusion time for the atopy patch test in the diagnosis of food allergies in children with atopic dermatitis?. Pediatr Allergy Immunol. 2004;15:93–96
- Antacid medication inhibits digestion of dietary proteins and causes food allergy: a fish allergy model in BALB/c mice. J Allergy Clin Immunol. 2003;112:616–623
- Anti-ulcer drugs promote IgE formation toward dietary antigens in adult patients. FASEB J. 2005;19:656–658
- Ringed oesophagus and idiopathic eosinophilic oesophagitis in adults: an association in two cases. Dig Liver Dis. 2005;37:129–134
- . Response to Straumann et al: primary eosinophilic esophagitis. Gastroenterology. 2004;127:364–365
- . Oral viscous budesonide: A potential new therapy for eosinophilic esophagitis in children. Am J Gastroenterol. 2007;102:1–9
- . Systemic adverse effects of inhaled corticosteroid therapy: a systematic review and meta-analysis. Arch Intern Med. 1999;159:941–955
- . Anti-interleukin-5 antibody therapy in eosinophilic diseases. Pathobiology. 2005;72:287–292
- Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. J Allergy Clin Immunol. 2004;113:115–119
- Variability in diagnostic criteria for eosinophilic esophagitis: a systematic review. Am J Gastroenterology. 2007;[in press]
- Retrospective analysis of esophageal food impaction: differences in etiology by age and gender. Dig Dis Sci. 2007;52:717–721
- Intermittent dysphagia for solids associated with a multiringed esophagus: clinical features and response to dilatation. Dysphagia. 2007;22:55–62
- Familial dysphagia and eosinophilia. Gastrointest Endosc. 2007;65:330–334
- Eosinophilic oesophagitis and coeliac disease: is there an association?. Aliment Pharmacol Ther. 2007;26:487–493
- . Erythema nodosum and eosinophilic oesophagitis: more than a chance association?. Br J Dermatol. 2007;156:1388–1389
- Eosinophilic esophagitis is a component of the anticonvulsant hypersensitivity syndrome: description of two cases. Dig Liver Dis. 2007;[in press]
- Pediatric patients with eosinophilic esophagitis: an 8-year follow-up. J Allergy Clin Immunol. 2007;119:731–738
- Prevalence of oesophageal eosinophils and eosinophilic oesophagitis in adults: the population-based Kalixanda study. Gut. 2007;56:615–620
- Emerging eosinophilic (allergic) esophagitis: increased incidence or increased recognition?. Arch Pathol Lab Med. 2007;131:777–779
- Allergen-specific in vitro cytokine production in adult patients with eosinophilic esophagitis. Dig Dis Sci. 2006;51:1934–1941
- Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis. J Allergy Clin Immunol. 2006;118:1312–1319
- Predictive values for skin prick test and atopy patch test for eosinophilic esophagitis. J Allergy Clin Immunol. 2007;119:509–511
- A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis. Gastroenterology. 2006;131:1381–1391
- Critical role for adaptive T-cell immunity in experimental eosinophilic esophagitis in mice. J Leukoc Biol. 2007;81:916–924
- Esophageal remodeling in pediatric eosinophilic esophagitis. J Allergy Clin Immunol. 2007;119:206–212
- Immunophenotypic characterization and quantification of the epithelial inflammatory infiltrate in eosinophilic esophagitis through stereology: an analysis of the cellular mechanisms of the disease and the immunologic capacity of the esophagus. Am J Surg Pathol. 2007;31:598–606
- Activated mucosal mast cells differentiate eosinophilic (allergic) esophagitis from gastroesophageal reflux disease. J Pediatr Gastroenterol Nutr. 2007;44:20–26
- Interplay of adaptive th2 immunity with eotaxin-3/c-C chemokine receptor 3 in eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2007;45:22–31
Supported by a small conference grant R13 DK076672 from the National Institutes of Health to The FIGER Symposium; North American Society of Pediatric Gastroenterology, Hepatology; the American Academy of Allergy, Asthma, and Immunology; The American Partnership for Eosinophilic Diseases; a philanthropic contribution from a grateful family; and educational grants (AstraZeneca, Abbot Laboratories, Nutricia, TAP, Ception, GlaxoSmithKline).
Conflict of interest disclosures: Glenn T. Furuta, consultant, Ception Therapeutics; speaker’s bureau, TAP; Chris A. Liacouras, consultant, SHS, Nutricia, Ception, Ross; grant/research support, Wyeth; speaker’s bureau, TAP, Merck; Margaret H. Collins, consultant, GlaxoSmithKline, Ception Therapeutics; Sandeep K. Gupta, consultant, GlaxoSmithKline, TAP, AstraZeneca, Salix; speaker’s bureau, Ross Products, TAP, AstraZeneca; educational grant, Ross Products; Christopher Justinich, no disclosures; Phil E. Putnam, no disclosures; Peter A Bonis, no disclosures; Eric Hassall, consultant, TAP Pharmaceuticals, Abbott Canada, Altana Pharma; clinical research grant, AstraZeneca; Alex Straumann, no disclosures; Marc E. Rothenberg, consultant, Merck, Ception Therapeutics, GlaxoSmithKline, MedaCorp; speaker’s bureau, Merck; Samuel Nurko, grant/research support, Wyeth pharmaceutica, TAP, Sucampo; Nirmala Gonsalves, consultant, Medacorp, Ception Therapeutics; Jonathan Markowitz, consultant, Ception Therapeutics; Don Antonioli, no disclosures; Eduardo Ruchelli, no disclosures; Hector Melin-Aldana, no disclosures; Margret Magid, no disclosures; Ikuo Hirano, no disclosures; David Katzka, no disclosures; Susan R. Orenstein, consultant, Ception Therapeutics, TAP, Braintree, AstraZeneca, Wyeth, Bristol Myers Squibb, McNeil; grant/research support, Braintree; Jonathan M. Spergel, consultant, Novartis, GlaxoSmithKline; grant/research support, Novartis, Nutricia; speaker’s bureau, AstraZeneca, GlaxoSmithKline; Amal Assa’ad, no disclosures; Seema Aceves, no disclosures; Barry K. Wershil, consultant, AP Pharmaceuticals, AstraZeneca; speaker’s bureau, Shire; educational grant, TAP Pharmaceuticals; Thomas Platts-Mills, no disclosures; Tusar Desai, no disclosures; Seema Khan, no disclosures; B Li, no disclosures; Amir F. Kagalwalla, no disclosures.
PII: S0016-5085(07)01474-6
doi: 10.1053/j.gastro.2007.08.017
© 2007 AGA Institute and North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition. Published by Elsevier Inc. All rights reserved.
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Gastroenterology
Volume 133, Issue 4
, Pages 1342-1363
, October 2007

