Gastroenterology
Volume 133, Issue 2 , Pages 710-712 , August 2007

Intestinal Development: The Many Faces of Wnt Signaling

  • Archana Kapoor
  • ,
  • H. Joyce Li
  • ,
  • Andrew B. Leiter

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to: Andrew Leiter, MD, Division of Gastroenterology/Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605. fax: (508) 856-4770.

References 

  1. Stappenbeck TS, Wong MH, Saam JR, et al. Notes from some crypt watchers: regulation of renewal in the mouse intestinal epithelium. Curr Opin Cell Biol. 1998;10:702–709
  2. Bienz M, Clevers H. Linking colorectal cancer to Wnt signaling. Cell. 2000;103:311–320
  3. Wodarz A, Nusse R. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol. 1998;14:59–88
  4. Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature. 2005;434:843–850
  5. Veeman MT, Axelrod JD, Moon RT. A second canon (Functions and mechanisms of beta-catenin-independent Wnt signaling). Dev Cell. 2003;5:367–377
  6. Waterman ML. Lymphoid enhancer factor/T cell factor expression in colorectal cancer. Cancer Metastasis Rev. 2004;23:41–52
  7. Korinek V, Barker N, Moerer P, et al. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet. 1998;19:379–383
  8. Kim B-M, Mao J, Taketo MM, et al. Phases of canonical Wnt signaling during the development of mouse intestinal epithelium. Gastroenterology. 2007;133:529–538
  9. Andreu P, Colnot S, Godard C, et al. Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine. Development. 2005;132:1443–1451
  10. van Es JH, Jay P, Gregorieff A, van Gijn ME, et al. Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat Cell Biol. 2005;7:381–386
  11. Pinto D, Gregorieff A, Begthel H, et al. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev. 2003;17:1709–1713
  12. Gregorieff A, Pinto D, Begthel H, et al. Expression pattern of Wnt signaling components in the adult intestine. Gastroenterology. 2005;129:626–638
  13. Mori-Akiyama Y, van den Born M, van Es JH, et al. SOX9 is required for the differentiation of Paneth cells in the intestinal epithelium. Gastroenterology. 2007;133:539–546
  14. Wang Y, Giel-Moloney M, Rindi G, et al. Enteroendocrine precursors differentiate independently of Wnt and form serotonin expressing adenomas in response to active β-catenin. Proc Natl Acad Sci U S A. 2007;104:11328–11333
  15. Schafer AJ, Dominguez-Steglich MA, Guioli S, et al. The role of SOX9 in autosomal sex reversal and campomelic dysplasia. Philos Trans R Soc Lond B Biol Sci. 1995;350:271–277discussion 277–278
  16. Dong C, Wilhelm D, Koopman P. Sox genes and cancer. Cytogenet Genome Res. 2004;105:442–447
  17. Blache P, van de Wetering M, Duluc I, et al. SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J Cell Biol. 2004;166:37–47
  18. Muncan V, Sansom OJ, Tertoolen L, et al. Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Mol Cell Biol. 2006;26:8418–8426
  19. Sansom OJ, Meniel VS, Muncan V, et al. Myc deletion rescues Apc deficiency in the small intestine. Nature. 2007;446:676–689
  20. Kikuchi A, Yamamoto H, Kishida S. Multiplicity of the interactions of Wnt proteins and their receptors. Cell Signal. 2007;19:659–671

PII: S0016-5085(07)01170-5

doi: 10.1053/j.gastro.2007.06.029

Gastroenterology
Volume 133, Issue 2 , Pages 710-712 , August 2007