Gastroenterology
Volume 132, Issue 3 , Pages 994-1008 , March 2007

Inhibition of TGF-β Signaling by IL-15: A New Role for IL-15 in the Loss of Immune Homeostasis in Celiac Disease

  • Mélika Benahmed

      Affiliations

    • INSERM U793, Paris, France
    • Université Paris Descartes, Faculté de Médecine René Descartes, Paris, France
    • M. Ben Ahmed was supported by INSERM, IRMAD, and AFDIAG (Association Française des Intolérants au Gluten).
    • ,
  • Bertrand Meresse

      Affiliations

    • INSERM U793, Paris, France
    • Université Paris Descartes, Faculté de Médecine René Descartes, Paris, France
    • ,
  • Bertrand Arnulf

      Affiliations

    • Université Paris Descartes, Faculté de Médecine René Descartes, Paris, France
    • CNRS UMR 8147, Paris, France
    • Department of Hematology, AP-HP, Hôpital Necker-Enfants Malades, Paris, France
    • ,
  • Ullah Barbe

      Affiliations

    • INSERM U793, Paris, France
    • Université Paris Descartes, Faculté de Médecine René Descartes, Paris, France
    • ,
  • Jean–Jacques Mention

      Affiliations

    • INSERM U793, Paris, France
    • Université Paris Descartes, Faculté de Médecine René Descartes, Paris, France
    • ,
  • Virginie Verkarre

      Affiliations

    • INSERM U793, Paris, France
    • Université Paris Descartes, Faculté de Médecine René Descartes, Paris, France
    • Department of Pathology, AP-HP, Hôpital Necker-Enfants Malades, Paris, France
    • ,
  • Matthieu Allez

      Affiliations

    • Department of Gastroenterology, AP-HP, Hôpital Saint Louis, Paris, France
    • ,
  • Christophe Cellier

      Affiliations

    • INSERM U793, Paris, France
    • Université Paris Descartes, Faculté de Médecine René Descartes, Paris, France
    • Department of Gastroenterology, AP-HP, Hôpital Européen Georges Pompidou, Paris, France
    • ,
  • Olivier Hermine

      Affiliations

    • Université Paris Descartes, Faculté de Médecine René Descartes, Paris, France
    • CNRS UMR 8147, Paris, France
    • Department of Hematology, AP-HP, Hôpital Necker-Enfants Malades, Paris, France
    • ,
  • Nadine Cerf–Bensussan

      Affiliations

    • INSERM U793, Paris, France
    • Université Paris Descartes, Faculté de Médecine René Descartes, Paris, France
    • Corresponding Author InformationAddress requests for reprints to: Nadine Cerf-Bensussan, MD, PhD, INSERM U793, Faculté de Médecine René Descartes-Paris 5, 156 rue de Vaugirard, 75730 Paris Cedex 15, France. fax: (33) 1-40-61-56-38.

Received 15 November 2005 ,Accepted 27 November 2006.

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 This work was sponsored by INSERM, by ARC Grant 4616, Canceropole Ile de France, and by La Fondation Princesse Grace de Monaco.

 The authors are grateful to members of the GERMC and particularly to Pr. M. Lehman (Hôpital Saint Louis), Dr. T. Matysiak-Budnik, Dr. D. Lamarque (Hôpital Hôtel Dieu), Pr. Chaussade (Hôpital Cochin), and Pr. Cugnenc (Hôpital Georges Pompidou) for providing material and information from their patients. The authors thank Dr. D. Buzoni-Gatel for helpful discussions and Mr. G. Pivert for technical support with histology.

PII: S0016-5085(06)02675-8

doi: 10.1053/j.gastro.2006.12.025

Gastroenterology
Volume 132, Issue 3 , Pages 994-1008 , March 2007

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