Gastroenterology
Volume 132, Issue 1 , Pages 113-118 , January 2007

Methionine and Vitamin B6 Intake and Risk of Pancreatic Cancer: A Prospective Study of Swedish Women and Men

  • Susanna C. Larsson

      Affiliations

    • Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    • Corresponding Author InformationAddress requests for reprints to: Susanna C. Larsson, PhD, Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, PO Box 210, SE - 17177 Stockholm, Sweden. fax: (46) 8-304571.
  • ,
  • Edward Giovannucci

      Affiliations

    • Departments of Nutrition and Epidemiology, Harvard School of Public Health, and Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts
  • ,
  • Alicja Wolk

      Affiliations

    • Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Received 6 August 2006 ,Accepted 21 September 2006.

References 

  1. Longnecker DS. Abnormal methyl metabolism in pancreatic toxicity and diabetes. J Nutr. 2002;132:2373S–2376S
  2. Choi SW, Mason JB. Folate and carcinogenesis: an integrated scheme. J Nutr. 2000;130:129–132
  3. Larsson SC, Håkansson N, Giovannucci E, Wolk A. Folate intake and pancreatic cancer incidence: a prospective study of Swedish women and men. J Natl Cancer Inst. 2006;98:407–413
  4. Stolzenberg-Solomon RZ, Albanes D, Nieto FJ, Hartman TJ, Tangrea JA, Rautalahti M, et al. Pancreatic cancer risk and nutrition-related methyl-group availability indicators in male smokers. J Natl Cancer Inst. 1999;91:535–541
  5. Stolzenberg-Solomon RZ, Pietinen P, Barrett MJ, Taylor PR, Virtamo J, Albanes D. Dietary and other methyl-group availability factors and pancreatic cancer risk in a cohort of male smokers. Am J Epidemiol. 2001;153:680–687
  6. Skinner HG, Michaud DS, Giovannucci EL, Rimm EB, Stampfer MJ, Willett WC, et al. A prospective study of folate intake and the risk of pancreatic cancer in men and women. Am J Epidemiol. 2004;160:248–258
  7. Baghurst PA, McMichael AJ, Slavotinek AH, Baghurst KI, Boyle P, Walker AM. A case-control study of diet and cancer of the pancreas. Am J Epidemiol. 1991;134:167–179
  8. Finkelstein JD, Cello JP, Kyle WE. Ethanol-induced changes in methionine metabolism in rat liver. Biochem Biophys Res Commun. 1974;61:525–531
  9. Barak AJ, Beckenhauer HC, Tuma DJ, Badakhsh S. Effects of prolonged ethanol feeding on methionine metabolism in rat liver. Biochem Cell Biol. 1987;65:230–233
  10. Piyathilake CJ, Macaluso M, Hine RJ, Richards EW, Krumdieck CL. Local and systemic effects of cigarette smoking on folate and vitamin B-12. Am J Clin Nutr. 1994;60:559–566
  11. Gabriel HE, Crott JW, Ghandour H, Dallal GE, Choi SW, Keyes MK, et al. Chronic cigarette smoking is associated with diminished folate status, altered folate form distribution, and increased genetic damage in the buccal mucosa of healthy adults. Am J Clin Nutr. 2006;83:835–841
  12. Bergström L, Kylberg E, Hagman U, Erikson H, Bruce Å. The food composition database KOST: the National Administration’s information system for nutritive values of food. Vår Föda. 1991;43:439–447
  13. Willett W, Stampfer MJ. Total energy intake: implications for epidemiologic analyses. Am J Epidemiol. 1986;124:17–27
  14. Messerer M, Johansson SE, Wolk A. The validity of questionnaire-based micronutrient intake estimates is increased by including dietary supplement use in Swedish men. J Nutr. 2004;134:1800–1805
  15. Mattsson B, Wallgren A. Completeness of the Swedish Cancer Register (Non-notified cancer cases recorded on death certificates in 1978). Acta Radiol Oncol. 1984;23:305–313
  16. Cox DR. Regression models and life tables (with discussion). J R Stat Soc (B). 1972;34:187–220
  17. Lowenfels AB, Maisonneuve P. Pancreatic cancer: development of a unifying etiologic concept. Ann N Y Acad Sci. 1999;880:191–200
  18. Balaghi M, Wagner C. Methyl group metabolism in the pancreas of folate-deficient rats. J Nutr. 1992;122:1391–1396
  19. Hoover KL, Poirier LA. Hepatocyte-like cells within the pancreas of rats fed methyl-deficient diets. J Nutr. 1986;116:1569–1575
  20. Chen RZ, Pettersson U, Beard C, Jackson-Grusby L, Jaenisch R. DNA hypomethylation leads to elevated mutation rates. Nature. 1998;395:89–93
  21. Kim YI. Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer?. Cancer Epidemiol Biomarkers Prev. 2004;13:511–519
  22. Parsa I, Marsh WH, Fitzgerald PJ. Pancreas acinar cell differentiation (VI. Effects of methyl donors and homocysteine). Fed Proc. 1972;31:166–175
  23. Balaghi M, Horne DW, Woodward SC, Wagner C. Pancreatic one-carbon metabolism in early folate deficiency in rats. Am J Clin Nutr. 1993;58:198–203
  24. Balaghi M, Wagner C. Folate deficiency inhibits pancreatic amylase secretion in rats. Am J Clin Nutr. 1995;61:90–96
  25. Farber E, Popper H. Production of acute pancreatitis with ethionine and its prevention by methionine. Proc Soc Exp Biol Med. 1950;74:838–840
  26. Goldberg RC, Chaikoff IL, Dodge AH. Destruction of pancreatic acinar tissue by DL-ethionine. Proc Soc Exp Biol Med. 1950;74:869–872
  27. Furukawa F, Nishikawa A, Lee IS, Son HY, Nakamura H, Miyauchi M, et al. Inhibition by methionine of pancreatic carcinogenesis in hamsters after initiation with N-nitrosobis(2-oxopropyl) amine. Cancer Lett. 2000;152:163–167
  28. Li D, Ahmed M, Li Y, Jiao L, Chou TH, Wolff RA, et al. 5,10-methylenetetrahydrofolate reductase polymorphisms and the risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2005;14:1470–1476
  29. Wang L, Miao X, Tan W, Lu X, Zhao P, Zhao X, et al. Genetic polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase and risk of pancreatic cancer. Clin Gastroenterol Hepatol. 2005;3:743–751
  30. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, et al A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10:111–113
  31. Klerk M, Verhoef P, Clarke R, Blom HJ, Kok FJ, Schouten EG. MTHFR 677C→T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA. 2002;288:2023–2031
  32. Matsubayashi H, Skinner HG, Iacobuzio-Donahue C, Abe T, Sato N, Riall TS, et al. Pancreaticobiliary cancers with deficient methylenetetrahydrofolate reductase genotypes. Clin Gastroenterol Hepatol. 2005;3:752–760
  33. Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA. 1993;270:2693–2698
  34. Borch K, Kullman E, Hallhagen S, Ledin T, Ihse I. Increased incidence of pancreatic neoplasia in pernicious anemia. World J Surg. 1988;12:866–870
  35. Karlson BM, Ekbom A, Wacholder S, McLaughlin JK, Hsing AW. Cancer of the upper gastrointestinal tract among patients with pernicious anemia: a case-cohort study. Scand J Gastroenterol. 2000;35:847–851
  36. Hsing AW, Hansson LE, McLaughlin JK, Nyren O, Blot WJ, Ekbom A, et al. Pernicious anemia and subsequent cancer (A population-based cohort study). Cancer. 1993;71:745–750
  37. Mellemkjaer L, Gridley G, Moller H, Hsing AW, Linet MS, Brinton LA, et al. Pernicious anaemia and cancer risk in Denmark. Br J Cancer. 1996;73:998–1000

 Supported by research grants from the Swedish Cancer Foundation and the Swedish Research Council/Longitudinal Studies.

PII: S0016-5085(06)02240-2

doi: 10.1053/j.gastro.2006.10.017

Gastroenterology
Volume 132, Issue 1 , Pages 113-118 , January 2007