Guidelines for Colonoscopy Surveillance After Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society

These graphs show the associations between adenoma characteristics at baseline and subsequent risk for (A) adenomas and for (B) advanced adenomas or colorectal cancer. The dotted line separates the results from the RCTs of surveillance and chemoprevention from the results from the observational cohort studies. Within the 2 groupings the studies are listed by year published. The graphs are presented for the baseline risk factors of adenoma multiplicity (≥3), adenoma size (≥1.0 cm), adenoma histology (tubulovillous or villous), (A) high-grade dysplasia, and proximal location (B). The left column is for the risk with respect to adenomas at surveillance, and the right column is for risk with respect to advanced neoplasia. The studies differ with respect to the classification levels of the risk factors and on the definition of advanced neoplasia. The specification of each study is given in the appendix (see supplemental material online at www.gastrojournal.org). The studies also cover different periods of follow-up evaluation and use different measures of effect such as ORs, relative risks, hazard ratios, and SIRs as noted in the appendix (see supplemental material online at www.gastrojournal.org). The term relative risk is used on the horizontal axis of the figure to represent these different measures of effect. The referent category for the ORs, relative risks, and hazard ratios is the lowest risk category. These estimates are denoted by black circles. Multivariate estimates are used when available. In 2 studies, SIRs were reported and are denoted by black squares. The referent category for the SIR is the general population. Note that Avidan et al³⁴ and Noshirwani et al³¹ used the number of adenomas, not more than 3 adenomas. CC, colon cancer; RC, rectal cancer. Relative risk represents the OR, relative risk, hazard ratio, or SIR as summarized for each study in the appendix (see supplemental material online at www.gastrojournal.org).