Gastroenterology
Volume 130, Issue 3 , Pages 940-987 , March 2006

American Gastroenterological Association Institute Technical Review on Corticosteroids, Immunomodulators, and Infliximab in Inflammatory Bowel Disease

  • Gary R. Lichtenstein

      Affiliations

    • Hospital of the University of Pennsylvania University of Pennsylvania School of Medicine Philadelphia, Pennsylvania
    • Corresponding Author InformationAddress requests for reprints to: Chair, Clinical Practice and Economics Committee, AGA National Office, c/o Membership Department, 4930 Del Ray Avenue, Bethesda, Maryland 20814. fax: (301) 654-5920
  • Maria T. Abreu

      Affiliations

    • Mount Sinai School of Medicine Mount Sinai Medical Center New York, New York
  • Russell Cohen

      Affiliations

    • University of Chicago Hospitals University of Chicago School of Medicine Chicago, Illinois
  • William Tremaine

      Affiliations

    • Mayo Clinic College of Medicine Mayo Clinic Rochester, Minnesota

  • Image Result

    Pathway involved with AZA and 6-MP metabolism. HGPRT, hypoxanthine guanine phosphoribosyl transferase; IMPDH, inosine monophosphate dehydrogenase; XO, xanthine oxidase; GMPS, guanine monophosphate syn

    Pathway involved with AZA and 6-MP metabolism. HGPRT, hypoxanthine guanine phosphoribosyl transferase; IMPDH, inosine monophosphate dehydrogenase; XO, xanthine oxidase; GMPS, guanine monophosphate synthetase; MPK, monophosphate kinase; DPK, diphosphate kinase.

 Dr. Lichtenstein is a consultant for Abbott Corporation, Astra-Zeneca, Inc., Axcan Corporation, Berlex, Centocor, Inc., Elan, Genetics Institute, Human Genome Sciences, Inkine, Inc., Intesco Corporation, ISIS Corporation, Millenium Pharmaceuticals, Otsuka Corporation, Proctor and Gamble, Prometheus Laboratories, Inc., Protein Design Labs, Protomed Scientific, Salix Pharmaceuticals, Schering-Plough Corporation, Serono, Shire Pharmaceuticals, Smith Kline Beecham Corporation, Solvay Pharmaceuticals, Synta Pharmaceuticals, UCB, and Wyeth.

 Dr. Tremaine is a consultant for Procter and Gamble, NPS Pharma, and Solvay Pharma.

 Dr. Abreu is a consultant for Procter and Gamble, Abbott, UCB, Prometheus, and Salix.

 Dr. Cohen is a consultant for Salix, Centocor, Abbott, Elan, Isis, Kenwood, McNeil, Pfizer, Protein Design Labs, Astra-Zeneca, Axcan-Scandipharm, Procter and Gamble, Salix, Solvay, and Shire.

 This literature review and the recommendations therein were prepared for the American Gastroenterological Association (AGA) Clinical Practice and Economics Committee. The paper was approved by the Committee on November 22, 2005, and by the AGA Governing Board on January 12, 2006.

 The American Gastroenterological Association received financial support from AstraZeneca LP to retain a contractor to assist in performing the background literature search for this work.

PII: S0016-5085(06)00074-6

doi: 10.1053/j.gastro.2006.01.048

Gastroenterology
Volume 130, Issue 3 , Pages 940-987 , March 2006

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