Gastroenterology
Volume 129, Issue 6 , Pages 1832-1844 , December 2005

Computed Tomographic Virtual Colonoscopy Computer-Aided Polyp Detection in a Screening Population

  • Ronald M. Summers

      Affiliations

    • Diagnostic Radiology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
    • Corresponding Author InformationAddress requests for reprints to: Ronald M. Summers, MD, PhD, Diagnostic Radiology Department, National Institutes of Health, Building 10, Room 1C660, 10 Center Drive MSC 1182, Bethesda, Maryland 20892-1182. fax: (301) 451-5721.
  • ,
  • Jianhua Yao

      Affiliations

    • Diagnostic Radiology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
  • ,
  • Perry J. Pickhardt

      Affiliations

    • Uniformed Services University of the Health Sciences, Bethesda, Maryland
    • National Naval Medical Center, Bethesda, Maryland
  • ,
  • Marek Franaszek

      Affiliations

    • Diagnostic Radiology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
  • ,
  • Ingmar Bitter

      Affiliations

    • Diagnostic Radiology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
  • ,
  • Daniel Brickman

      Affiliations

    • Diagnostic Radiology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
  • ,
  • Vamsi Krishna

      Affiliations

    • Diagnostic Radiology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
  • ,
  • J. Richard Choi

      Affiliations

    • Uniformed Services University of the Health Sciences, Bethesda, Maryland
    • Walter Reed Army Medical Center, Washington, DC

Received 15 June 2005 ,Accepted 17 August 2005.

References 

  1. Jemal A, Tiwari RC, Murray T, Ghafoor A, Samuels A, Ward E, et al. Cancer statistics, 2004 . CA Cancer J Clin . 2004;54:8–29
  2. Gluecker TM, Johnson CD, Harmsen WS, Offord KP, Harris AM, Wilson LA, et al. Colorectal cancer screening with CT colonography, colonoscopy, and double-contrast barium enema examination (prospective assessment of patient perceptions and preferences) . Radiology . 2003;227:378–384
  3. van Gelder RE, Birnie E, Florie J, Schutter MP, Bartelsman JF, Snel P, et al. CT colonography and colonoscopy (assessment of patient preference in a 5-week follow-up study) . Radiology . 2004;233:328–337
  4. Pickhardt PJ, Choi JR, Hwang I, Butler JA, Puckett ML, Hildebrandt HA, et al. Computed tomographic virtual colonoscopy to screen for colorectal neoplasia in asymptomatic adults . N Engl J Med . 2003;349:2191–2200
  5. Pineau BC, Paskett ED, Chen GJ, Espeland MA, Phillips K, Han JP, et al. Virtual colonoscopy using oral contrast compared with colonoscopy for the detection of patients with colorectal polyps . Gastroenterology . 2003;125:304–310
  6. Cotton PB, Durkalski VL, Benoit PC, Palesch YY, Mauldin PD, Hoffman B, et al. Computed tomographic colonography (virtual colonoscopy) (a multicenter comparison with standard colonoscopy for detection of colorectal neoplasia) . JAMA . 2004;291:1713–1719
  7. Rockey DC, Paulson E, Niedzwiecki D, Davis W, Bosworth HB, Sanders L, et al. Analysis of air contrast barium enema, computed tomographic colonography, and colonoscopy (prospective comparison) . Lancet . 2005;365:305–311
  8. Johnson CD, Harmsen WS, Wilson LA, Maccarty RL, Welch TJ, Ilstrup DM, et al. Prospective blinded evaluation of computed tomographic colonography for screen detection of colorectal polyps . Gastroenterology . 2003;125:311–319
  9. Johnson CD, Toledano AY, Herman BA, Dachman AH, McFarland EG, Barish MA, et al. Computerized tomographic colonography (performance evaluation in a retrospective multicenter setting) . Gastroenterology . 2003;125:688–695
  10. Summers RM , Yoshida H . Future directions (computer-aided diagnosis) . In:  Dachman AH editors. Atlas of virtual colonoscopy . New York, NY: Springer; 2003;p. 55–62
  11. Yoshida H , Nappi J , MacEneaney P , Rubin DT , Dachman AH . Computer-aided diagnosis scheme for detection of polyps at CT colonography . Radiographics . 2002;22:963–979
  12. Summers RM , Johnson CD , Pusanik LM , Malley JD , Youssef AM , Reed JE . Automated polyp detection at CT colonography (feasibility assessment in a human population) . Radiology . 2001;219:51–59
  13. Kiss G , Van Cleynenbreugel J , Thomeer M , Suetens P , Marchal G . Computer-aided diagnosis in virtual colonography via combination of surface normal and sphere fitting methods . Eur Radiol . 2002;12:77–81
  14. Paik DS, Beaulieu CF, Rubin GD, Acar B, Jeffrey RB, Yee J, et al. Surface normal overlap (a computer-aided detection algorithm, with application to colonic polyps and lung nodules in helical CT) . IEEE Trans Med Imaging . 2004;23:661–675
  15. Cathier P, Periaswamy S, Jerebko A, Dundar M, Liang J, Fung G, et al. In: CAD for polyp detection: an invaluable tool to meet the increasing need for colon cancer screening. CARS 2004–Computer Assisted Radiology and Surgery, Proceedings of the 18th International Congress and Exhibition, June 23–26, 2004 . 2004;p. 978–982 Chicago, IL
  16. Kiraly AP , Laks S , Macari M , Geiger B , Bogoni L , Nova CL . In: A fast method for colon polyp detection in high-resolution CT data screening. CARS 2004–Computer Assisted Radiology and Surgery, Proceedings of the 18th International Congress and Exhibition, June 23–26, 2004 . 2004;p. 983–988 Chicago, IL
  17. Summers RM , Jerebko AK , Franaszek M , Malley JD , Johnson CD . Colonic polyps (complementary role of computer-aided detection in CT colonography) . Radiology . 2002;225:391–399
  18. Pickhardt PJ , Choi JH . Electronic cleansing and stool tagging in CT colonography (advantages and pitfalls with primary three-dimensional evaluation) . AJR Am J Roentgenol . 2003;181:799–805
  19. Pickhardt PJ , Nugent PA , Mysliwiec PA , Choi JR , Schindler WR . Location of adenomas missed by optical colonoscopy . Ann Intern Med . 2004;141:352–359
  20. Iordanescu G , Pickhardt PJ , Choi JR , Summers RM . Automated seed placement for colon segmentation in computed tomography colonography . Acad Radiol . 2005;12:182–190
  21. Summers RM , Franaszek M , Miller MT , Pickhardt PJ , Choi JR , Schindler WR . Computer-aided detection of polyps on oral contrast-enhanced CT colonography . Am J Roentgenol . 2005;184:105–108
  22. Yao J , Summers RM . In: Three-dimensional colonic polyp segmentation using dynamic deformable surfaces . San Diego, CA: SPIE Medical Imaging; 2004;p. 280–289
  23. Jerebko AK , Malley JD , Franaszek M , Summers RM . In: Computer-aided polyp detection in CT colonography using an ensemble of support vector machines. CARS 2003–Computer Assisted Radiology and Surgery, Proceedings of the 17th International Congress and Exhibition, June 2003 . London, England: Elsevier; 2003;p. 1019–1024
  24. Malley JD , Jerebko AK , Summers RM . In: Committee of support vector machines for detection of colonic polyps from CT scans . San Diego, CA: SPIE Medical Imaging; 2003;p. 570–578
  25. Gur D , Wagner RF , Chan HP . On the repeated use of databases for testing incremental improvement of computer-aided detection schemes . Acad Radiol . 2004;11:103–105
  26. Yao JH , Campbell S , Hara AK , Summers RM . In: Progressive feature vector selection scheme for computer-aided colonic polyp detection . 2004;p. 633; Presented at: RSNA Scientific Assembly and Annual Meeting, November 2004, Chicago, IL
  27. Bitter I , Brown JE , Brickman D , Summers RM . In: Large scale validation of a computer aided polyp detection algorithm for CT colonography using cluster computing . San Diego, CA: SPIE Medical Imaging; 2004;p. 290–294
  28. Chakraborty DP . The FROC, AFROC and DROC variants of the ROC analysis. Chapter 16 . In:  Beutel J ,  Kundel HL ,  Van Metter RL editor. Handbook of medical imaging . Bellingham, WA: SPIE Press; 2000;p. 771–796
  29. Vining DJ , Shifrin RY , Grishaw EK , Liu K , Gelfand DW . Virtual colonoscopy . (abstr) Radiology . 1994;193(P):446
  30. Yee J , Akerkar GA , Hung RK , Steinauer-Gebauer AM , Wall SD , McQuaid KR . Colorectal neoplasia (performance characteristics of CT colonography for detection in 300 patients) . Radiology . 2001;219:685–692
  31. Ferrucci J, Barish M, Choi R, Dachman A, Fenlon H, Glick S, et al. Virtual colonoscopy . JAMA . 2004;292:431–432 author reply 433
  32. Halligan S , Taylor S , Burling D . Virtual colonoscopy . JAMA . 2004;292:432; author reply 433
  33. Pickhardt PJ . Virtual colonoscopy . JAMA . 2004;292:431; author reply 433
  34. Summers RM , Bitter I , Petrick N . Virtual colonoscopy . JAMA . 2004;292:432–433
  35. Macari M , Milano A , Lavelle M , Berman P , Megibow AJ . Comparison of time-efficient CT colonography with two- and three- dimensional colonic evaluation for detecting colorectal polyps . AJR Am J Roentgenol . 2000;174:1543–1549
  36. McFarland EG, Brink JA, Pilgram TK, Heiken JP, Balfe DM, Hirselj DA, et al. Spiral CT colonography (reader agreement and diagnostic performance with two- and three-dimensional image-display techniques) . Radiology . 2001;218:375–383
  37. Gluecker T, Meuwly JY, Pescatore P, Schnyder P, Delarive J, Jornod P, et al. Effect of investigator experience in CT colonography . Eur Radiol . 2002;12:1405–1409
  38. Taylor SA, Halligan S, Burling D, Morley S, Bassett P, Atkin W, et al. CT colonography (effect of experience and training on reader performance) . Eur Radiol . 2004;14:1025–1033
  39. Pickhardt PJ . Three-dimensional endoluminal CT colonography (virtual colonoscopy) (comparison of three commercially available systems) . AJR Am J Roentgenol . 2003;181:1599–1606
  40. Fletcher JG, Johnson CD, Welch TJ, MacCarty RL, Ahlquist DA, Reed JE, et al. Optimization of CT colonography technique (prospective trial in 180 patients) . Radiology . 2000;216:704–711
  41. Jiang Y , Nishikawa RM , Schmidt RA , Toledano AY , Doi K . Potential of computer-aided diagnosis to reduce variability in radiologists’ interpretations of mammograms depicting microcalcifications . Radiology . 2001;220:787–794
  42. Freer TW , Ulissey MJ . Screening mammography with computer-aided detection (prospective study of 12,860 patients in a community breast center) . Radiology . 2001;220:781–786
  43. Paik DS , Beaulieu CF , Jeffrey RB , Yee J , Steinauer-Gebauer AM , Napel S . Computer aided detection of polyps in CT colonography (method and free-response ROC evaluation of performance) . (abstr) Radiology . 2000;217:704
  44. Gokturk SB, Tomasi C, Acar B, Beaulieu CF, Paik DS, Jeffrey RB, et al. A statistical 3-D pattern processing method for computer-aided detection of polyps in CT colonography . IEEE Trans Med Imaging . 2001;20:1251–1260
  45. Acar B, Beaulieu CF, Gokturk SB, Tomasi C, Paik DS, Jeffrey RB, et al. Edge displacement field-based classification for improved detection of polyps in CT colonography . IEEE Trans Med Imaging . 2002;21:1461–1467
  46. Kiss G , Van Cleynenbreugel J , Thomeer M , Suetens P , Marchal G . In: Computer aided diagnosis for virtual colonography. Proceedings of the 4th International Conference on Medical Image Computing and Computer-Assisted Intervention . Utrecht: The Netherlands: Springer-Verlag; 2001;p. 621–628
  47. Yoshida H , Nappi J . Three-dimensional computer-aided diagnosis scheme for detection of colonic polyps . IEEE Trans Med Imaging . 2001;20:1261–1274
  48. Yoshida H , Nappi J , MacEneaney P , Rubin DT , Dachman AH . Computer-aided diagnosis scheme for the detection of polyps in CT colonography . Radiographics . 2002;22:963–979
  49. Nappi JJ , Frimmel H , Dachman AH , Yoshida H . Computerized detection of colorectal masses in CT colonography based on fuzzy merging and wall-thickening analysis . Med Phys . 2004;31:860–872
  50. Summers RM, Beaulieu CF, Pusanik LM, Malley JD, Jeffrey RB, Glazer DI, et al. Automated polyp detector for CT colonography (feasibility study) . Radiology . 2000;216:284–290
  51. Summers RM , Jerebko A , Franaszek M , Malley JD , Johnson CD . Complementary role of computer-aided detection of colonic polyps with CT colonography . Radiology . 2002;225:391–399
  52. Mani A, Napel S, Paik DS, Jeffrey RB, Yee J, Olcott EW, et al. Computed tomography colonography (feasibility of computer-aided polyp detection in a “first reader” paradigm) . J Comput Assist Tomogr . 2004;28:318–326
  53. Summers RM, Dempsey J, Campbell SR, Yao J, Franaszek M, Brickman D, et al. CT colonography with intravenous contrast enhancement (computer-aided polyp and mass detection) . (abstr) Am J Roentgenol . 2004;182:75
  54. Yoshida H , Nappi JJ , Frimmel H , Miller FH , Dalal KA , Dachman AH . In: Computer-aided detection of polyps in CT colonography (performance evaluation based on combination of independent databases) . 2003;p. 672; Presented at: RSNA Scientific Assembly and Annual Meeting, November 2003, Chicago, IL
  55. Bogoni L , Jerebko A , Dundar M , Lee J , Baker M , Macari M . In: A multisite study to evaluate performance of CAD in polyp detection . 2004;p. 577; Presented at: RSNA Scientific Assembly and Annual Meeting, November 2004, Chicago, IL
  56. Franaszek M , Summers RM , Pickhardt PJ , Choi JR , Schindler W . In: Assessment of obscured colonic surface in CT colonography . 2004;p. 618; Presented at: RSNA Scientific Assembly and Annual Meeting, November 2004, Chicago, IL

 P.J.P.’s current affiliation is: Department of Radiology, University of Wisconsin Medical School, Madison, Wisconsin.This research was supported by the Intramural Research Program of the National Institutes of Health, Warren G. Magnuson Clinical Center. Viatronix supplied the V3D Colon software free of charge. This study used the high-performance computational capabilities of the Biowulf Linux cluster at the National Institutes of Health in Bethesda, Maryland (http://biowulf.nih.gov).

PII: S0016-5085(05)01772-5

doi: 10.1053/j.gastro.2005.08.054

Gastroenterology
Volume 129, Issue 6 , Pages 1832-1844 , December 2005