Gastroenterology
Volume 129, Issue 3 , Pages 1111-1113 , September 2005

A Search for the Holy Grail: Non-Toxic Gluten for Celiac Patients

  • Marco Londei

      Affiliations

    • Institute of Child Health, University College London, London, England
    • Corresponding Author InformationAddress reprint requests to: Marco Londei, MD, Institute of Child Health, University College London, London, WC1N 1EH, England; fax: (44) 20 790 52316.
    • ,
  • Luigi Maiuri

      Affiliations

    • Institute of Child Health, University College London, London, England
    • Cancer Research UK Clinical Centre, Southampton General Hospital, University of Southampton, Southampton, England
    • ,
  • Sonia Quaratino

      Affiliations

    • Cancer Research UK Clinical Centre, Southampton General Hospital, University of Southampton, Southampton, England

References 

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  2. Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, et al. Identification of tissue transglutaminase as the autoantigen of celiac disease . Nat Med . 1997;3:797–801
  3. Gillespie KM, Bain SC, Barnett AH, Bingley PJ, Christie MR, Gill GV, et al. The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes . Lancet . 2004;364:1699–1700
  4. Ivarsson A, Persson LA, Nystrom L, Ascher H, Cavell B, Danielsson L, et al. Epidemic of coeliac disease in Swedish children . Acta Paediatr . 2000;89:165–171
  5. Sollid LM . Coeliac disease (dissecting a complex inflammatory disorder) . Nat Rev Immunol . 2002;2:647–655
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  8. Molberg O, Mcadam SN, Korner R, Quarsten H, Kristiansen C, Madsen L, et al. Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease . Nat Med . 1998;4:713–717
  9. van de Wal Y, Kooy Y, van Veelen P, Pena S, Mearin L, Papadopoulos G, et al. Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity . J Immunol . 1998;161:1585–1588
  10. van de Wal Y , Kooy Y , van Veelen P , Vader W , Koning F , Pena S . Coeliac disease (it takes three to tango!) . Gut . 2000;46:734–737
  11. Vader W, Stepniak D, Kooy Y, Mearin L, Thompson A, van Rood JJ, et al. The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses . Proc Natl Acad Sci U S A . 2003;100:12390–12395
  12. Shan L, Molberg O, Parrot I, Hausch F, Filiz F, Gray GM, et al. Structural basis for gluten intolerance in celiac sprue . Science . 2002;297:2275–2279
  13. Piper JL , Gray GM , Khosla C . Effect of prolyl endopeptidase on digestive-resistant gliadin peptides in vivo . J Pharmacol Exp Ther . 2004;311:213–219
  14. Shan L , Marti T , Sollid LM , Gray GM , Khosla C . Comparative biochemical analysis of three bacterial prolyl endopeptidases (implications for coeliac sprue) . Biochem J . 2004;383:311–318
  15. Farrell RJ , Kelly CP . Celiac sprue . N Engl J Med . 2002;346:180–188
  16. Catassi C , Bearzi I , Holmes GK . Association of celiac disease and intestinal lymphomas and other cancers . Gastroenterology . 2005;128:S79–S86
  17. Matysiak–Budnik T, Candalh C, Cellier C, Dugave C, Namane A, Vidal–Martinez T, et al. Limited efficiency of prolyl-endopeptidase in the detoxification of gliadin peptides in celiac disease . Gastroenterology . 2005;129:786–796
  18. Spaenij–Dekking L, Kooy–Winkelaar Y, van Veelen P, Wouter Drijfhout J, Jonker H, van Soest L, et al. Natural variation in toxicity of wheat (potential for selection of non-toxic varieties for celiac disease patients) . Gastroenterology . 2005;129:797–806
  19. Maiuri L, Ciacci C, Ricciardelli I, Vacca L, Raia V, Auricchio S, et al. Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease . Lancet . 2003;362:30–37
  20. Molberg O, Uhlen AK, Jensen T, Flaete NS, Fleckenstein B, Arentz-Hansen H, et al. Mapping of gluten T-cell epitopes in the bread wheat ancestors (implications for celiac disease) . Gastroenterology . 2005;128:393–401

PII: S0016-5085(05)01547-7

doi: 10.1053/j.gastro.2005.07.039

Gastroenterology
Volume 129, Issue 3 , Pages 1111-1113 , September 2005

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