Gastroenterology
Volume 129, Issue 3 , Pages 827-836 , September 2005

The Clustering of Other Chronic Inflammatory Diseases in Inflammatory Bowel Disease: A Population-Based Study

  • Charles N. Bernstein

      Affiliations

    • Inflammatory Bowel Disease Clinical and Research Centre, University of Manitoba, Manitoba, Canada
    • Section of Gastroenterology, Department of Internal Medicine, University of Manitoba, Manitoba, Canada
    • Corresponding Author InformationAddress requests for reprints to: Charles N. Bernstein, MD, University of Manitoba, 804F-715 McDermot Avenue, Winnipeg, Manitoba, Canada R3E-3P4. fax: (204) 789-3972.
    • ,
  • Andre Wajda

      Affiliations

    • Inflammatory Bowel Disease Clinical and Research Centre, University of Manitoba, Manitoba, Canada
    • ,
  • James F. Blanchard

      Affiliations

    • Inflammatory Bowel Disease Clinical and Research Centre, University of Manitoba, Manitoba, Canada
    • Department of Community Health Sciences, Winnipeg, Manitoba, Canada

Received 26 January 2005 ,Accepted 26 May 2005.

References 

  1. Davidson A , Diamond B . Autoimmune disease . N Engl J Med . 2001;345:340–350
  2. Ginn LR , Lin JP , Plotz PH , et al.   Familial autoimmunity in pedigrees of idiopathic inflammatory myopathy patients suggests common genetic risk factors for many autoimmune diseases . Arthritis Rheum . 1998;41:400–405
  3. Becker KG , Simon RM , Bailey-Wilson JE , et al.   Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases . Proc Natl Acad Sci U S A . 1998;95:9979–9984
  4. Bernstein CN , Blanchard JF , Rawsthorne P , Yu N . The prevalence of extraintestinal diseases in inflammatory bowel disease (a population-based study) . Am J Gastroenterol . 2001;96:1116–1122
  5. Roos LL , Mustard CA , Nicol JP . Registries and administrative data (organization and accuracy) . Med Care . 1993;31:201–212
  6. Bernstein CN , Blanchard JF , Rawsthorne P , Wajda A . The epidemiology of Crohn’s disease and ulcerative colitis in a central Canadian province (a population-based study) . Am J Epidemiol . 1999;149:916–924
  7. Elliott LJ , Yu N , Melanson M , Green C , Blanchard J . Application of a validated method using medical claims data to demonstrate very high prevalence and incidence of multiple sclerosis in a Canadian province . Am J Epidemiol . 2004;159:S59
  8. Bernstein CN , Blanchard JF , Leslie WD , Wajda A , Yu N . The incidence of fractures among patients with IBD (a population-based study) . Ann Intern Med . 2000;133:795–799
  9. Bernstein CN , Blanchard JF , Houston D , Wajda A . The incidence of venous thromboembolic disease among patients with IBD (a population-based study) . Thromb Haemost . 2001;85:430–434
  10. Bernstein CN , Kliewer E , Wajda A , Blanchard JF . The incidence of cancer among patients with IBD (a population-based study) . Cancer . 2001;91:854–862
  11. Ricart E , Tremaine W , Harmsen WS , Zinsmeister AR , Sandborn WJ . Autoimmune disorders and extraintestinal manifestations in first degree familial and sporadic inflammatory bowel disease (a case-control study) . Inflamm Bowel Dis . 2004;10:207–214
  12. Haslock I , Wright V . The musculoskeletal complications of Crohn’s disease . Medicine . 1973;52:217–225
  13. Salvarani C, Vlachonikolis IG, van der Heijde DM, Fornaciari G, Macchioni P, Beltrami M, et al. Musculoskeletal manifestations in a population-based cohort of inflammatory bowel disease patients . Scand J Gastroenterol . 2001;36:1307–1313
  14. Orchard TR , Wordworth BP , Jewell DP . Peripheral arthropathies in inflammatory bowel disease (their articular distribution and natural history) . Gut . 1998;42:387–391
  15. Herrlinger KR , Noftz MK , Dalhoff K , Ludwig D , Stange EF , Fellerman K . Alterations in pulmonary function in inflammatory bowel disease are frequent and persist during remission . Am J Gastroenterol . 2002;97:377–381
  16. Kuzela L, Vavreka A, Prikazska M, Drugda B, Hronec J, Senkova A, et al. Pulmonary complications in patients with inflammatory bowel disease . Hepatogastroenterology . 1999;46:1714–1719
  17. Dierkes-Globisch A , Mohr H-H . Pulmonary abnormalities in respiratory asymptomatic patients with inflammatory bowel disease . Eur J Int Med . 2002;13:385–388
  18. Birring SS, Morgan AJ, Prudon B, McKeever TM, Lewis SA, Falconer Smith JF, et al. Respiratory symptoms in patients with treated hypothyroidism and inflammatory bowel disease . Thorax . 2003;58:533–536
  19. Godet PG , Cowie R , Woodman RC , et al.   Pulmonary function abnormalities in patients with ulcerative colitis . Am J Gastroenterol . 1997;92:7
  20. Songur N, Songur Y, Tuzun M, Dogan I, Tuzun D, Ensari A, et al. Pulmonary function tests and high-resolution CT in the detection of pulmonary involvement in inflammatory bowel disease . J Clin Gastroenterol . 2003;37:292–298
  21. Mahadeva R , Walsh G , Flower CDR , Shneerson JM . Clinical and radiological characteristics of lung disease in inflammatory bowel disease . Eur Respir J . 2000;15:41–48
  22. Fireman Z, Osipov A, Kivity S, Kopelman Y, Sternberg A, Lazarov E, et al. The use of induced sputum in the assessment of pulmonary involvement in Crohn’s disease . Am J Gastroenterol . 2000;95:730–734
  23. Storch I , Sachar D , Katz S . Pulmonary manifestations of inflammatory bowel disease . Inflamm Bowel Dis . 2003;9:104–115
  24. Camus P , Piard F , Ashcroft T , et al.   The lung in inflammatory bowel disease . Medicine (Baltimore) . 1993;72:151–183
  25. Casey MB, Tazelaar HD, Myers JL, Hunninghake GW, Kakar S, Kalra SX, et al. Noninfectious lung pathology inpatients with Crohn’s disease . Am J Surg Pathol . 2003;27:213–219
  26. Bernstein CN , Blanchard JF . Disease-related health care utilization is higher in Crohn’s disease than ulcerative colitis . Gastroenterology . 1999;116:A668
  27. Parry SD , Barbatzas C , Peel ET , et al.   Sulfasalazine and lung toxicity . Eur Respir J . 2002;19:756–764
  28. Bitton A , Peppercorn MA , Hanrahan JP , et al.   Mesalamine-induced lung toxicity . Am J Gastroenterol . 1996;91:1039–1040
  29. Sviri S , Gafanaovich I , Kramer MR , et al.   Mesalamine-induced hypersensitivity pneumonitis. A case report and review of the literature . J Clin Gastroenterol . 1997;24:34–36
  30. Camus P , Colby TV . The lung in inflammatory bowel disease . Eur Respir J . 2000;15:5–10
  31. Rang EH , Brooke BN , Herman-Taylor J . Association of ulcerative colitis with multiple sclerosis (letter) . Lancet . 1982;2:555
  32. Purman J , Arendt G , Cleveland S , et al.   Association of Crohn’s disease and multiple sclerosis . J Clin Gastroenterol . 1992;14:43–46
  33. Minuk GY , Lewkonia RM . Possible familial association of multiple sclerosis and inflammatory bowel disease . N Engl J Med . 1986;314:586
  34. Sadovnik AD , Paty DW , Yannakoulias G . Concurrence of multiple sclerosis and inflammatory bowel disease . N Engl J Med . 1989;321:762–763
  35. Kimura K, Hunter SF, Thollander MS, Loftus EV, Melton LJ, OBrien PC, et al. Concurrence of inflammatory bowel disease and multiple sclerosis . Mayo Clin Proc . 2000;75:802–806
  36. Yacyshyn B , Meddings J , Sadowski D , Bowen-Yacyshyn MB . Multiple sclerosis patients have peripheral blood CD45RO+ B cells and increased intestinal permeability . Dig Dis Sci . 1996;41:2493–2498
  37. Sedwick LA , Klingele TG , Burde RM , Behrens MM . Optic neuritis in inflammatory bowel disease . J Clin Neuroopthalmol . 1984;4:3–6
  38. Zimmerman J , Steiner I , Gavish D , et al.   Guillain-Barre syndrome (a possible extraintestinal manifestation of ulcerative colitis) . J Clin Gastroenterol . 1985;7:301–303
  39. Nemni R , Fazio R , Corbo M , et al.   Peripheral neuropathy associated with Crohn’s disease . Neurology . 1987;37:1414–1417
  40. Humbert P , Monnier G , Billerey C , et al.   Polyneuropathy an unusual extraintestinal manifestation of Crohn’s disease . Acta Neurol Scand . 1989;80:301–306
  41. Lossos A , River Y , Eliakim R , Steiner I . Neurologic aspects of inflammatory bowel disease . Neurology . 1995;45:416–421
  42. Summers RW , Harker L . Ulcerative colitis and sensorineural hearing loss (is there a relationship?) . J Clin Gastroenterol . 1982;4:251–252
  43. Bachmeyer C, Leclerc-Landgraf N, Laurette F, Coutarel P, Cadranel J-F, Medioni J, et al. Acute sensorineural hearing loss associated with Crohn’s disease . Am J Gastroenterol . 1998;93:2565–2567
  44. Ilnyckyj A , Aldor TAM , Warrington R , Bernstein CN . Crohn’s disease and the Melkersson-Rosenthal syndrome . Can J Gastroenterol . 1999;13:152–154
  45. Duffy LF , Daum F , Fisher SE , et al.   Peripheral neuropathy in Crohn’s disease patients treated with metronidazole . Gastroenterology . 1985;88:681–684
  46. Finnie IA , Shields R , Sutton R , Donnelly R , Morris AI . Crohn’s disease and myasthenia gravis (a possible role for thymectomy) . Gut . 1994;35:278–279
  47. Wilcox GM , Aretz HT , Roy MA , Roche JK . Glomerulonephritis associated with inflammatory bowel disease . Gastroenterology . 1990;98:786–791
  48. Pardi DS , Tremaine WJ , Sandborn WJ , McCarthy JT . Renal and urologic complications of inflammatory bowel disease . Am J Gastroenterol . 1998;93:504–514
  49. Shaer AJ , Stewart LR , Cheek DE , Hurray D , Self SE . IgA antiglomerular basement membrane nephritis associated with Crohn’s disease (a case report and review of glomerulonephritis in inflammatory bowel disease) . Am J Kidney Dis . 2003;41:1097–1109
  50. World MJ , Stevens PE , Ashton MA , et al.   Mesalazine-associated interstitial nephritis . Nephrol Dial Transplant . 1996;11:614–621
  51. Popoola J , Muller AF , Pollock L , et al.   Late onset interstitial nephritis associated with mesalazine treatment . BMJ . 1998;317:795–797
  52. DeBroe ME , Stolear JC , Nouwen EJ , et al.   5-Aminosalicylic acid and chronic tubulointerstitial nephritis in patients with chronic inflammatory bowel disease (is there a link?) . Nephrol Dial Transplant . 1997;12:1839–1841
  53. Ransford RAJ , Langman MJS . Sulphasalazine and mesalazine (serious adverse reactions re-evaluated on the basis of suspected adverse reaction reports to the Committee on Safety of Medicines) . Gut . 2002;51:536–539
  54. Elseviers MM, D’Haens G, Lerebours E, Plane C, Stolear JC, Riegler G, et al. Renal impairment in patients with inflammatory bowel disease (association with aminosalicylate therapy?) . Clin Nephrol . 2004;61:83–89
  55. Van Staa TP , Travis S , Leufkens HG , Logan RF . 5-aminosalicylic acids and the risk of renal disease (a large British epidemiologic study) . Gastroenterology . 2004;126:1733–1739
  56. Yates VM , Watkinson G , Kelman A . Further evidence for an association between psoriasis, Crohn’s disease and ulcerative colitis . Br J Dermatol . 1982;105:323–330
  57. Lee FI , Bellary SV , Francis C . Increased occurrence of psoriasis in patients with Crohn’s disease . Am J Gastroenterol . 1990;85:962–963
  58. Scarpa R, Manguso F, D’Arienzo A, D’Armiento FP, Astarita C, Mazzacca G, et al. Microscopic inflammatory changes in colon of patients with both active psoriasis and psoriatic arthritis without bowel symptoms . J Rheumatol . 2000;27:1241–1246
  59. Najarian DJ , Gottlieb AB . Connections between psoriasis and Crohn’s disease . J Am Acad Dermatol . 2003;48:805–821
  60. Snook JA , de Silva HJ , Jewell DP . The association of autoimmune disorders with inflammatory bowel disease . QJM . 1989;72:835–840
  61. Bonapace ES , Srinivasan R . Simultaneous occurrence of inflammatory bowel disease and thyroid disease . Am J Gastroenterol . 2001;86:1925–1926
  62. Shah SA , Peppercorn MA , Palotta JA . Autoimmune (Hashimoto’s) thyroiditis associated with Crohn’s disease . J Clin Gastroenterol . 1998;26:117–120
  63. Triantafillidis JK , Cherakakis P , Zervakakis A , et al.   Coexistence of hyperthyroidism and ulcerative colitis (report of 4 cases and a review of the literature) . Ital J Gastroenterol . 1992;24:494–497
  64. Mukhopadhyay D , Nasr K , Grossma BJ , Kirsner JB . Pericarditis associated with inflammatory bowel disease . JAMA . 1970;211:1540–1542
  65. Rheingold OJ . Inflammatory bowel disease and pericarditis . Ann Intern Med . 1975;21:760–763
  66. Patwardan RV , Heilpern RJ , Brewstere AC , Darrah JJ . Pleuropericarditis an extraintestinal complication of inflammatory bowel disease . Arch Intern Med . 1983;143:94–96
  67. Hoffmann RM , Kruis W . Rare extraintestinal manifestations of inflammatory bowel disease . Inflamm Bowel Dis . 2004;10:140–147
  68. Farmer RG , Hawk W , Turnbull RB . Clinical patterns in Crohn’s disease (a statistical study of 615 cases) . Gastroenterology . 1975;68:627–635
  69. Greenstein AJ , Janowitz HD , Sachar DB . The extra-intestinal complications of Crohn’s disease and ulcerative colitis. A study of 700 patients . Medicine . 1976;55:401–412

 Supported in part by a Canadian Institutes of Health Research Investigator Award and by a Crohn’s and Colitis Foundation of Canada Research Scientist Award (to C.N.B.).

PII: S0016-5085(05)01123-6

doi: 10.1053/j.gastro.2005.06.021

Gastroenterology
Volume 129, Issue 3 , Pages 827-836 , September 2005

Article Tools