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Gastroenterology
Volume 129, Issue 3
, Pages 902-912
, September 2005
Epithelial Barrier Function In Vivo Is Sustained Despite Gaps in Epithelial Layers
References
- . The future of GI and liver research: editorial perspectives: I. Visions of epithelial research . Am J Physiol Gastrointest Liver Physiol . 2003;284:G547–G550
- . A porous defense (the leaky epithelial barrier in intestinal disease) . Lab Invest . 2004;84:282–291
- . Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt . Development . 1990;110:1001–1020
- . Permeability of the rat small intestinal epithelium along the villus-crypt axis (effects of glucose transport) . Gastroenterology . 2000;119:1029–1036
- . Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation . Am J Physiol . 1997;273:C1378–C1385
- . Intestinal permeability in children with Crohn’s disease and coeliac disease . Br Med J (Clin Res Ed) . 1982;285:20–21
- . Intestinal permeability in patients with Crohn’s disease and their healthy relatives . Gastroenterology . 1989;97:927–931
- . The gut mucosal barrier in bone marrow transplantation . Bone Marrow Transplant . 1990;5:373–377
- . CD45RO expression on circulating CD19+ B cells in Crohn’s disease correlates with intestinal permeability . Gastroenterology . 1995;108:132–137
- . IL-4 directly modulates function of a model human intestinal epithelium . J Immunol . 1994;153:2122–2129
- . Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin . Science . 1995;270:1203–1207
- . Increased intestinal permeability precedes the onset of Crohn’s disease in a subject with familial risk . Gastroenterology . 2000;119:1740–1744
- . Intestinal epithelial responses to enteric pathogens (effects on the tight junction barrier, ion transport, and inflammation) . Gut . 2003;52:439–451
- . Heparan sulfate depletion amplifies TNF-α-induced protein leakage in an in vitro model of protein-losing enteropathy . Am J Physiol Gastrointest Liver Physiol . 2005;288:G1015–G1023
- . Emerging concepts in colorectal neoplasia . Gastroenterology . 2002;123:862–876
- . Epithelial integrity, cell death and cell loss in mammalian small intestine . Histol Histopathol . 1999;14:257–267
- . A novel mechanism for disposing of effete epithelial cells in the small intestine of guinea pigs . Gastroenterology . 1993;105:1089–1097
-
.
Regulation of cell number in the mammalian gastrointestinal tract
(the importance of apoptosis)
.
J Cell Sci
. 1994;107:3569–3577
- . Apoptotic signaling during initiation of detachment-induced apoptosis (“anoikis”) of primary human intestinal epithelial cells . Cell Growth Differ . 2001;12:147–155
- . Caspase activation during spontaneous and radiation-induced apoptosis in the murine intestine . J Pathol . 2001;195:285–292
- . An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism . Curr Biol . 2001;11:1847–1857
- . Intestinal epithelial restitution. Characterization of a cell culture model and mapping of cytoskeletal elements in migrating cells . J Clin Invest . 1992;89:1501–1511
- . A novel cytoskeletal structure involved in purse string wound closure and cell polarity maintenance . J Cell Biol . 1993;121:565–578
- . PKC-dependent regulation of transepithelial resistance (roles of MLC and MLC kinase) . Am J Physiol . 1999;277:C554–C562
- . A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability . J Biol Chem . 2004;279:55506–55513
- . Maintenance of the macromolecular barrier at cell extrusion sites in intestinal epithelium (physiological rearrangement of tight junctions) . J Membr Biol . 1990;116:177–184
- . Villus contraction aids repair of intestinal epithelium after injury . Am J Physiol . 1989;257:G274–G283
- . Single-cell epithelial defects close rapidly by an actinomyosin purse string mechanism with functional tight junctions . J Physiol . 2002;545:485–499
- . Dynamic regulation of gastric surface pH by luminal pH . J Clin Invest . 1999;103:605–612
- . Endogenous cyclo-oxygenase activity regulates mouse gastric surface pH . J Physiol . 2002;544:871–882
- . Functional studies of the kidney of living animals using multicolor two-photon microscopy . Am J Physiol Cell Physiol . 2002;283:C905–C916
- . Quantitative NAD(P)H/flavoprotein autofluorescence imaging reveals metabolic mechanisms of pancreatic islet pyruvate response . J Biol Chem . 2004;279:31780–31787
- . Vital imaging and ultrastructural analysis of individual axon terminals labeled by iontophoretic application of lipophilic dye . J Neurosci Methods . 1999;93:13–20
- . Modulation of barrier function during Fas-mediated apoptosis in human intestinal epithelial cells . Gastroenterology . 2000;119:1524–1536
- . Tubular lysosomes accompany stimulated pinocytosis in macrophages . J Cell Biol . 1987;104:1217–1222
- . DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis . Cell . 1997;89:175–184
- . Assessment of caspase activities in intact apoptotic thymocytes using cell-permeable fluorogenic caspase substrates . J Exp Med . 2000;191:1819–1828
- . Control of adhesion-dependent cell survival by focal adhesion kinase . J Cell Biol . 1996;134:793–799
- . Ultrastructure of cell loss in intestinal mucosa . J Ultrastruct Res . 1977;60:272–277
- . Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor . Science . 1996;274:262–265
- . Trefoil factors (initiators of mucosal healing) . Nat Rev Mol Cell Biol . 2003;4:721–732
- . Cytokines modulate fibroblast phenotype and epithelial-stroma interactions in rat intestine . Gastroenterology . 1997;112:826–838
- . Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2 . Am J Physiol . 1997;273:G1341–G1348
- . Myofibroblasts. II. Intestinal subepithelial myofibroblasts . Am J Physiol . 1999;277:C183–C201
- . Congenital enterocyte heparan sulphate deficiency with massive albumin loss, secretory diarrhoea, and malnutrition . Lancet . 1996;347:1299–1301
- . Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation . J Cell Biol . 1992;119:493–501
- . Apoptosis and colorectal cancer . Gut . 2004;53:1701–1709
- . Cell migration velocities in the crypts of the small intestine after cytotoxic insult are not dependent on mitotic activity . Cell Tissue Kinet . 1986;19:601–610
- . Further evidence of species variation in mechanisms of epithelial cell loss in mammalian small intestine (ultrastructural studies on the reindeer (Rangifer tarandus) and seal (Phoca groenlandica)) . Cell Tissue Res . 1998;291:513–523
Supported in part by a grant from the HVC Foundation (Grant no. 10).The authors have no competing financial interests.
PII: S0016-5085(05)01117-0
doi: 10.1053/j.gastro.2005.06.015
© 2005 American Gastroenterological Association. Published by Elsevier Inc. All rights reserved.
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Gastroenterology
Volume 129, Issue 3
, Pages 902-912
, September 2005

