Gastroenterology
Volume 126, Issue 4 , Pages 1190-1193 , April 2004

IGF2 loss of imprinting: a potential heritable risk factor for colorectal cancer

  • Randy L. Jirtle

      Affiliations

    • Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
    • Corresponding Author InformationAddress requests for reprints to: Randy L. Jirtle, Ph.D, Department of Radiation Oncology, Duke University Medical Center, Box 3433, Durham, North Carolina 27710 USA fax: (919) 684-5584

References 

  1. Cruz-Correa M, Cui H, Giardiello FM, Powe NR, Hylind L, Robinson A, et al. Loss of imprinting of Insulin Growth Factor-II gene (a potential heritable biomarker for colon neoplasia predisposition). Gastroenterology. 2004;126:964–970
  2. Jirtle RL. Genomic imprinting and cancer. Exp Cell Res. 1999;248:18–24
  3. Grady WM, Markowitz SD. Genetic and epigenetic alterations in colon cancer. Ann Rev Genomics Hum Genet. 2002;3:101–128
  4. Kahlenberg MS, Sullivan JM, Witmer DD, Petrelli NJ. Molecular prognostics in CRC. Surg Oncol. 2003;12:173–186
  5. Momparler RL. Cancer epigenetics. Oncogene. 2003;22:6479–6483
  6. Feinberg AP, Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature. 1983;301:89–92
  7. Veigl ML, Kasturi L, Olechnowicz J, Ma AH, Lutterbaugh JD, Periyasamy S, et al. Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. Proc Natl Acad Sci U S A. 1998;95:8698–8702
  8. Esteller M, Herman JG. Cancer as an epigenetic disease (DNA methylation and chromatin alterations in human tumours). J Pathol. 2002;196:1–7
  9. Feinberg AP, Tycko B. Timeline (the history of cancer epigenetics). Nat Rev Cancer. 2004;4:1–11
  10. Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med. 2003;349:2042–2054
  11. Reik W, Walter J. Genomic imprinting (parental influence on the genome). Nat Rev Genet. 2001;2:21–32
  12. McGrath J, Solter D. Completion of mouse embryogenesis requires both the maternal and paternal genomes. Cell. 1984;37:179–183
  13. Surani MA, Barton SC, Norris ML. Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis. Nature. 1984;308:548–550
  14. Mutter GL. Role of imprinting in abnormal human development. Mutat Res. 1997;396:141–147
  15. DeChiara TM, Robertson EJ, Efstratiadis A. Parental imprinting of the mouse insulin-like growth factor II gene. Cell. 1991;64:849–859
  16. Murphy SK, Jirtle RL. Imprinting evolution and the price of silence. Bioessays. 2003;25:577–588
  17. Killian JK, Byrd JC, Jirtle JV, Munday BL, Stoskopf MK, MacDonald RG, et al. M6P/IGF2R imprinting evolution in mammals. Mol Cell. 2000;5:707–716
  18. Reik W, Walter J. Genomic imprinting (parental influence on the genome). Nat Rev Genet. 2001;2:21–32
  19. Sleutels F, Barlow DP. The origins of genomic imprinting in mammals. Adv Genet. 2002;46:119–163
  20. Moore T, Haig D. Genomic imprinting in mammalian development (a parental tug-of-war). Trends Genet. 1991;7:45–49
  21. Haig D, Graham C. Genomic imprinting and the strange case of the insulin-like growth factor II receptor. Cell. 1991;64:1045–1046
  22. Steenman MJC, Rainier S, Dobry CJ, Grundy P, Horon IL, Feinberg AP. Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms’ tumour. Nat Genet. 1994;7:433–439
  23. Moulton T, Crenshaw T, Hao Y, Moosikasuwan J, Lin N, Dembitzer F, et al. Epigenetic lesions at the H19 locus in Wilms’ tumour patients. Nat Genet. 1994;7:440–447
  24. Falls JG, Pulford DJ, Wylie AA, Jirtle RL. Genomic imprinting (implications for human disease). Am J Pathol. 1999;154:635–647
  25. Cui H, Onyango P, Brandenburg S, Wu Y, Hsieh CL, Feinberg AP. Loss of imprinting in CRC linked to hypomethylation of H19 and IGF2. Cancer Res. 2002;62:6442–6446
  26. Cui H, Cruz-Correa M, Giardiello FM, Hutcheon DF, Kafonek DR, Brandenburg S, et al. Loss of IGF2 imprinting (a potential marker of CRC risk). Science. 2003;299:1753–1755
  27. Cui H, Horon IL, Ohlsson R, Hamilton SR, Feinberg AP. Loss of imprinting in normal tissue of CRC patients with microsatellite instability. Nat Med. 1998;4:1276–1280
  28. Uejima H, Lee MP, Cui H, Feinberg AP. Hot-stop PCR (a simple and general assay for linear quantitation of allele ratios). Nat Genet. 2000;25:375–376
  29. Waterland RA, Jirtle RL. Transposable elements (targets for early nutritional effects on epigenetic gene regulation). Mol Cell Biol. 2003;23:5293–5300
  30. Wylie AA, Murphy SK, Orton TC, Jirtle RL. Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation. Genome Res. 2000;10:1711–1718
  31. Sullivan MJ, Taniguchi T, Jhee A, Kerr N, Reeve AE. Relaxation of IGF2 imprinting in Wilms tumours associated with specific changes in IGF2 methylation. Oncogene. 1999;18:7527–7534
  32. Killian JK, Nolan CM, Wylie AA, Li T, Vu TH, Hoffman AR, et al. Divergent evolution in M6P/IGF2R imprinting from the Jurassic to the Quaternary. Hum Mol Genet. 2001;10:1721–1728
  33. Paulsen M, El-Maarri O, Engemann S, Strodicke M, Franck O, Davies K, et al. Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse. Hum Mol Genet. 2000;9:1829–1841

 Supported by National Institutes of Health Grants CA25951 and ES08823.

PII: S0016-5085(04)00298-7

doi: 10.1053/j.gastro.2004.02.026

Gastroenterology
Volume 126, Issue 4 , Pages 1190-1193 , April 2004