« Previous
Next »
Gastroenterology
Volume 119, Issue 6
, Pages 1637-1648
, December 2000
Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: A double-blind, placebo-controlled trial
References
- . Corticosteroid therapy of alcoholic hepatitis. Gastroenterology. 1978;75:193–199
- . Failure of colchicine to improve short-term survival in patients with alcoholic hepatitis. Gastroenterology. 1990;99:811–818
- . A randomized trial of prednisolone in patients with severe alcoholic hepatitis. N Engl J Med. 1992;326:507–512
- . Do corticosteroids reduce mortality from alcoholic hepatitis?. Ann Intern Med. 1990;113:299–307
-
.
Treatment of acute alcoholic hepatitis.
Gastroenterol Int. 1989;2:208–216
- . Corticosteroids in severe alcoholic hepatitis. Ann Intern Med. 1989;110:677–680
- . Increased plasma tumor necrosis factor in severe alcoholic hepatitis. Ann Intern Med. 1990;112:917–920
- . Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients. Hepatology. 1991;13:267–276
- . Increased plasma interleukin-8 concentrations in alcoholic hepatitis. Hepatology. 1993;18:576–580
- . Circulating and tissue levels of neutrophil chemotaxin interleukin-8 are elevated in severe acute alcoholic hepatitis, and tissue levels correlate with neutrophil infiltration. Hepatology. 1993;18:41–46
- . Cytokines and alcoholic liver disease. Semin Liver Dis. 1993;13:170–182
- . Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology. 1989;9:349–351
- . Immunohistochemical detection of tumor necrosis factor-alpha, other cytokines and adhesion molecules in human livers with alcoholic hepatitis. Virchows Arch A Pathol Anat Histopathol. 1993;423:169–176
-
.
Pentoxifylline may prevent renal impairment (hepatorenal syndrome) in severe acute alcoholic hepatitis (abstr).
Hepatology. 1991;14:96A
- . ARDS, neutrophils and pentoxifylline. Am Rev Respir Dis. 1988;138:1103–1105
- . Oxpentifylline in endotoxaemia. Lancet. 1989;2:1474–1477
- . Pentoxifylline suppression of tumor necrosis factor gene transcription. Surgery. 1991;110:192–198
- . Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor for analysis at separate points in the signaling pathway. J Exp Med. 1990;172:391–394
- . An improved method of estimating the portal venous fraction of total hepatic blood flow from computerized radionuclide angiography. Radiology. 1983;147:559–562
-
.
Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease.
Hepatology. 1995;21:1304–1309
- . Association of a tumor necrosis factor promoter polymorphism with susceptibility to alcoholic steatohepatitis. Hepatology. 1997;26:143–146
- . Cytokine-induced hepatic intercellular adhesion molecule-1 (ICAM-1) mRNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure. Hepatology. 1995;21:1632–1639
- . The role of cytokine networks in the local liver injury following hepatic ischemia/reperfusion in the rat. Hepatology. 1996;23:506–514
- . Cytokineinduced neutrophil chemoattractant release from hepatocytes is modulated by Kupffer cells. Hepatology. 1996;23:353–358
- . Novel tumor necrosis factor toxic effects. Pulmonary hemorrhage and severe hepatic dysfunction. Cancer. 1992;69:256–260
-
.
Pentoxifylline inhibits increased serum tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) levels and improves renal function in patients with hepatorenal syndrome (abstr).
Hepatology. 1996;24:450A
- . Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs. 1987;34:50–97
- . Successful treatment of Behçet disease with pentoxifylline. Ann Intern Med. 1996;124:891–893
- . Treatment of Behçet disease with pentoxifylline (letter). Ann Intern Med. 1997;126:493
- . Alcoholic hepatitis: natural history and evaluation of prednisolone therapy. Ann Intern Med. 1971;74:311–321
- . Treatment of alcoholic hepatitis with encephalopathy: comparison of prednisolone with caloric supplements. Gastroenterology. 1978;74:169–173
- . Methylprednisolone therapy in patients with severe alcoholic hepatitis. A randomized multicenter trial. Ann Intern Med. 1989;110:685–690
- . Survival and prognostic factors in patients with severe alcoholic hepatitis treated with prednisolone. Gastroenterology. 1996;110:1847–1853
- . Prednisone therapy of acute alcoholic hepatitis: report of a controlled trial. Ann Intern Med. 1973;79:625–631
- . Double-blind controlled trial of prednisolone therapy in patients with severe acute alcoholic hepatitis and spontaneous encephalopathy. Gastroenterology. 1980;78:524–529
- . Glucocorticoids are ineffective in alcoholic hepatitis: a meta-analysis adjusting for confounding variables. Gut. 1995;37:113–118
- . Cytokine levels in acute alcoholic hepatitis: a sequential study. Drug Alcohol Depend. 1995;39:23–27
- . Plasma tumor necrosis factor-α predicts decreased long-term survival in severe alcoholic hepatitis. Alcohol Clin Exp Res. 1990;14:255–259
- . Pentoxifylline for intermittent claudication: a critical review. Angiology. 1994;45:339–345
- . Phase I–II trial of pentoxifylline for the prevention of transplant-related toxicities following bone marrow transplantation. Blood. 1991;78:1205–1211
- . Phase Ib trial of pentoxifylline and ciprofloxacin in patients treated with interleukin-2 and lymphokine-activated killer cell therapy for metastatic renal cell carcinoma. Cancer Res. 1994;54:3436–3441
☆ No reprints available.
☆☆ Financial support for TNF measurements was kindly provided by Hoeschst-Roussel Pharmaceuticals Inc.
PII: S0016-5085(00)51183-4
© 2000 American Gastroenterological Association. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Gastroenterology
Volume 119, Issue 6
, Pages 1637-1648
, December 2000

