Gastroenterology
Volume 92, Issue 6 , Pages 1885-1893 , June 1987

Altered small bowel motility in irritable bowel syndrome is correlated with symptoms

  • John E. Kellow

      Affiliations

    • J.E. Kellow was supported in part by a scholarship from the Medical Foundation, the University of Sydney, Australia.
    • ,
  • Sidney F. Phillips

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to: Sidney F. Phillips, M.D., Gastroenterology Unit, Mayo Clinic, 200 Southwest First Street, Rochester, Minnesota 55905.

Received 1 July 1986 ,Accepted 17 November 1986.

References 

  1. Switz DM. What the gastroenterologist does all day. Gastroenterology. 1976;70:1048–1050
  2. Ferguson A, Sircus W, Eastwood MA. Frequency of “functional” gastrointestinal disorders. Lancet. 1977;ii:613–614
  3. Chaudhary NA, Truelove SC. The irritable colon syndrome. Q J Med. 1962;31:307–322
  4. Manning AP, Thompson WG, Heaton KW, Morris AF. Towards positive diagnosis of the irritable bowel. Br Med J. 1978;2:653–654
  5. Harvey RF, Salih SY, Read AE. Organic and functional disorders in 2000 gastroenterology outpatients. Lancet. 1983;i:632–634
  6. U.S. Department of Health, Education, and Welfare , Public Health Service , National Institutes of Health . DHEW Publication No. (NIH) 79-1878. 1979;
  7. Connell AM. The motility of the pelvic colon. II. Paradoxical motility in diarrhea and constipation. Gut. 1962;3:342–348
  8. Wangel AG, Deller DJ. Intestinal motility in man. III. Mechanisms of constipation and diarrhea with particular reference to the irritable bowel syndrome. Gastroenterology. 1965;48:69–83
  9. Snape WJ, Carlson GM, Cohen S. Colonic myoelectrical activity in the irritable bowel syndrome. Gastroenterology. 1976;70:326–330
  10. Snape WJ, Carlson GM, Matarazzo SA, et al.  Evidence that abnormal myoelectrical activity produces colonic motor dys-function in the irritable bowel syndrome. Gastroenterology. 1977;72:383–387
  11. Taylor I, Darby C, Hammond P. Comparison of rectosigmoid myoelectrical activity in the irritable colon syndrome during relapses and remissions. Gut. 1978;19:923–929
  12. Buéno L, Fioramonti J, Ruckebusch Y, Frexinos J, Coulom P. Evaluation of colonic myoelectrical activity in health and functional disorders. Gut. 1980;21:480–485
  13. Lasser RB, Bond JH, Levitt MD. The role of intestinal gas in functional abdominal pain. N Engl J Med. 1975;293:524–526
  14. Whorwell PJ, Clouter C, Smith CL. Esophageal motility in the irritable bowel syndrome. Br Med J. 1981;1:1101–1103
  15. Moriarty KJ, Dawson AM. Functional abdominal pain: further evidence that whole gut is affected. Br Med J. 1982;284:1670–1672
  16. Cann PA, Read NW, Brown C, Hobson N, Holdsworth CD. Irritable bowel syndrome: relationship of disorders in the transit of a single solid meal to symptom patterns. Gut. 1983;24:405–411
  17. Jian R, Najean Y, Bernier JJ. Measurement of intestinal progression of a meal and its residues in normal subjects and patients with functional diarrhea by a dual isotope technique. Gut. 1984;25:728–731
  18. Horowitz L, Farrar JT. Intraluminal small intestinal pressures in normal patients and in patients with functional gastrointestinal disorders. Gastroenterology. 1962;42:455–464
  19. Holdstock DJ, Misiewicz JJ, Waller SL. Observations on the mechanism of abdominal pain. Gut. 1969;10:19–31
  20. Szurszewski JH. A migrating electric complex of the canin small intestine. Am J Physiol. 1969;217:1757–1763
  21. Thompson DG, Laidlow JM, Wingate DL. Abnormal small bowel motility demonstrated by radiotelemetry in a patient with irritable colon. Lancet. 1979;ii:1321–1322
  22. Kingham JGC, Brown R, Colson R, Clark ML. Jejunal motility in patients with functional abdominal pain. Gut. 1984;25:375–380
  23. Kumar D, Wingate DL. The irritable bowel syndrome: aparoxysmal motor disorder. Lancet. 1985;ii:973
  24. Borody T, Byrnes D, Bell D, Henderson L. The migrating motor complex; its relation to circulating CCK, motilin, and pancreatic polypeptide in irritable bowel patients and in controls (abstr). Clin Res. 1984;32:23A
  25. Kellow J, Borody TJ, Phillips SF, Tucker RL, Haddad AC. Human interdigestive motility: variations in patterns from esophagus to colon. Gastroenterology. 1986;91:386–395
  26. Quigley EMM, Borody TJ, Phillips SF, Wienbeck M, Tucker RL, Haddad A. Motility of the terminal ileum and ileocecal sphincter in healthy humans. Gastroenterology. 1984;87:857–866
  27. Kerlin P, Phillips SF. Variability of motility of the ileum and jejunum in healthy humans. Gastroenterology. 1982;82:694–700
  28. Latimer PR. Functional gastrointestinal disorders. A behavioral medicine approach. New York: Springer; 1983;
  29. Colligan RC, Osborne D, Swenson WM, Offord KP. The aging MMPI: development of contemporary norms. In: Mayo Clin Proc. 59:1984;p. 377–390
  30. Colligan RC, Osborne D, Swenson WM, Offord KR. The MMPI: a contemporary normative study. New York: Praeger; 1983;
  31. Arndorfer RC, Stef JJ, Dodds WJ, Lineham JH, Hogan WJ. Improved infusion system for intraluminal esophageal manometry. Gastroenterology. 1977;73:23–27
  32. Kerlin P, Tucker R, Phillips SF. Rapid intubation of the ileocolonic region of man. Aust NZ J Med. 1983;13:591
  33. Kumar D, Wingate DL. The human MMC moves slowly by night (abstr). Gastroenterology. 1985;88:1459
  34. Summers RW, Anuras S, Green J. Jejunal mamometry patterns in health, partial intestinal obstruction and pseudo-obstruction. Gastroenterology. 1983;85:1290–1300
  35. Code C, Rogers AG, Schlegel J, Hightower NC, Bargen JA. Motility patterns in the terminal ileum: studies on two patients with ulcerative colitis and iliac stomas. Gastroenterology. 1957;32:651–665
  36. Quigley EMM, Phillips SF, Dent J. Distinctive patterns of interdigestive motility at the canine ileocolonic junction. Gastroenterology. 1984;87:836–844
  37. Kruis W, Azpiroz F, Phillips SF. Contractile patterns and transit of fluid in canine terminal ileum. Am J Physiol. 1985;249:G264–G270
  38. Mathias JR, Carlson GM, DiMarino AJ, Bertiger G, Morton HE, Cohen S. Intestinal myoelectric activity in response to live Vitrio cholerase and cholera enterotoxin. J Clin Invest. 1976;58:91–96
  39. Mathias JR, Martin JL, Burns TW, Carlson GM, Shields RP. Ricinoleic acid effects on the electrical activity of the small intestine in rabbits. J Clin Invest. 1978;61:640–644
  40. Fleckenstein P, Oigaard A. Electrical spike activity in the human small intestine. A multiple electrode study of fasting diurnal variations. Dig Dis Sci. 1978;23:776–780
  41. Fleckenstein P, Bueno L, Fioramonti J, Ruckebusch Y. Minute rhythm of electrical spike bursts of the small intestine in different species. Am J Physiol. 1982;242:G654–G659
  42. Whitehead WE, Schuster MM. Irritable bowel syndrome: physiological and psychological mechanisms. In: Gastrointestinal disorders. Behavioral and physiological basis for treatment. New York: Academic; 1985;
  43. Wingate DL. Backwards and forwards with the migrating complex. Dig Dis Sci. 1981;26:641–664
  44. Sarna SK. Cyclic motor activity: migrating motor complex: 1985. Gastroenterology. 1985;89:894–913
  45. Wood JD. Enteric neurophysiology. Am J Physiol. 1984;247:G585–G598

☆ This work was supported in part by grants AM32121, AM34988, and RR585 from the National Institutes of Health, Bethesda, Maryland.

PII: 0016-5085(87)90620-2

Gastroenterology
Volume 92, Issue 6 , Pages 1885-1893 , June 1987

Article Tools