Gastroenterology
Volume 77, Issue 3 , Pages 540-546 , September 1979

A controlled comparison of continuous intraarterial and intravenous infusions of vasopressin in hemorrhage from esophageal varices

  • M. Chojkier

      Affiliations

    • Liver Research Laboratory, Veterans Administration Medical Center, West Haven, Connecticut, USA
    • The Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    • ,
  • R.J. Groszmann

      Affiliations

    • Liver Research Laboratory, Veterans Administration Medical Center, West Haven, Connecticut, USA
    • The Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    • ,
  • C.E. Atterbury

      Affiliations

    • Liver Research Laboratory, Veterans Administration Medical Center, West Haven, Connecticut, USA
    • The Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    • ,
  • S. Bar-Meir

      Affiliations

    • Liver Research Laboratory, Veterans Administration Medical Center, West Haven, Connecticut, USA
    • The Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    • ,
  • A.T. Blei

      Affiliations

    • Liver Research Laboratory, Veterans Administration Medical Center, West Haven, Connecticut, USA
    • The Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    • ,
  • J. Frankel

      Affiliations

    • Liver Research Laboratory, Veterans Administration Medical Center, West Haven, Connecticut, USA
    • The Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    • ,
  • M.G. Glickman

      Affiliations

    • Liver Research Laboratory, Veterans Administration Medical Center, West Haven, Connecticut, USA
    • The Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    • ,
  • J.L. Kniaz

      Affiliations

    • Liver Research Laboratory, Veterans Administration Medical Center, West Haven, Connecticut, USA
    • The Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    • ,
  • R. Schade

      Affiliations

    • Liver Research Laboratory, Veterans Administration Medical Center, West Haven, Connecticut, USA
    • The Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    • ,
  • G.J. Taggart

      Affiliations

    • Liver Research Laboratory, Veterans Administration Medical Center, West Haven, Connecticut, USA
    • The Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    • ,
  • H.O. Conn

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to: H. O. Conn, M.D., VA Medical Center, West Haven, Connecticut 06516.
    • Liver Research Laboratory, Veterans Administration Medical Center, West Haven, Connecticut, USA
    • The Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

Received 3 January 1979 ,Accepted 11 May 1979.

References 

  1. Kehne JH, Hughes FA, Gompertz ML. The use of surgical pituitrin in the control of esophageal varix bleeding: an experimental study and report of two cases. Surgery. 1956;39:917
  2. Merigan TC, Plotkin GR, Davidson CS. Effect of intravenously administered posterior pituitary extract on hemorrhage from bleeding esophageal varices. A controlled evaluation. N Engl J Med. 1962;266:134
  3. Conn HO, Ramsby GR, Storer EH, et al.  Intraarterial vasopressin in the treatment of upper gastrointestinal hemorrhage: a prospective, controlled clinical trial. Gastroenterology. 1975;68:211
  4. Mallory A, Schaefer JW, Cohen JR, et al: Selective intraarterial vasopressin for upper gastrointestinal hemorrhage: a controlled trial. Arch Surg (in press)
  5. Johnson WC, Widrich WC, Ansell JE, et al.  Control of bleeding varices by vasopressin: a prospective randomized study. Ann Surg. 1977;186:369
  6. Baum S, Nusbaum M. The control of gastrointestinal hemorrhage by selective mesenteric arterial infusion of vasopressin. Radiology. 1971;98:497
  7. Baum S, Athanasoulis CA, Waltman AC. Angiographic diagnosis and control of large-bowel bleeding. Dis Colon Rectum. 1974;17:447
  8. Athanasoulis CA, Baum S, Waltman AC, et al.  Control of acute gastric mucosal hemorrhage. N Engl J Med. 1974;290:597
  9. Schwartz SI, Bales HW, Emerson GL, et al.  The use of intravenous pituitrin in treatment of bleeding esophageal varices. Surgery. 1959;45:72
  10. Shaldon S, Sherlock S. The use of vasopressin (“Pitressin”) in the control of bleeding from oesophageal varices. Lancet. 1960;2:222
  11. Conn HO, Dalessio DJ. Multiple infusions of posterior pituitary extract in the treatment of bleeding esophageal varices. Ann Intern Med. 1962;57:804
  12. Thomford NR, Sirinek KR. Intravenous vasopressin in patients with portal hypertension: Advantages of continuous infusion. J Surg Res. 1975;18:113
  13. Kaufman SL, Maddrey WC, Harrington DP, et al.  Hemodynamic effects of superior mesenteric arterial and intravenous vasopressin infusions in patients with portal hypertension. Invest Radiol. 1977;12:210
  14. Rigberg LA, Ufberg MH, Brooks CM. Continuous low dose peripheral vein pitressin infusion in the control of variceal bleeding. Am J Gastroenterol. 1977;68:481
  15. Freedman AR, Kerr JC, Swan KG, et al.  Primate mesenteric blood flow. Effects of vasopressin and its route of delivery. Gastroenterology. 1978;74:875
  16. Conn HO, Ramsby GR, Storer EH. Selective intraarterial vasopressin the treatment of upper gastrointestinal hemorrhage. Gastroenterology. 1972;63:634
  17. Marubbio AT, Lombardo RP, Holt PR. Control of variceal bleeding by superior mesenteric artery pitressin perfusions. Complications and indications. Am J Dig Dis. 1973;18:539
  18. Marubbio AT. Antidiuretic hormone effect of pitressin during continuous pitressin infusion. Gastroenterology. 1972;62:1103
  19. Millette B, Huet P-M, Lavoie P, et al.  Portal and systemic effects of selective infusion of vasopressin into the superior mesenteric artery in cirrhotic patients. Gastroenterology. 1975;69:6
  20. Renert WA, Button KF, Fuld SL, et al.  Mesenteric venous thrombosis and small-bowel infarction following infusion of vasopressin into the superior mesenteric artery. Radiology. 1972;102:299
  21. Johnson WC, Widrich WC. Efficacy of selective splanchnic arteriography and vasopressin perfusion in diagnosis and treatment of gastrointestinal hemorrhage. Am J Surg. 1976;131:481
  22. Berardi RS. Vascular complications of superior mesenteric artery infusion with pitressin in treatment of bleeding esophageal varices. Am J Surg. 1974;127:757
  23. Kaufman SL, Harrington DP, Barth KH, et al.  Control of variceal bleeding by superior mesenteric artery vasopressin infusion. Am J Roentgenol. 1977;128:567
  24. Murray-Lyon IM, Pugh RNH, Nunnerley HB, et al.  Treatment of bleeding oesophageal varices by infusion of vasopressin into the superior mesenteric artery. Gut. 1973;14:59
  25. Getzen LC, Brink RR, Wolfman EF. Survival following infusion of pitressin into the superior mesenteric artery to control bleeding esophageal varices in cirrhotic patients. Ann Surg. 1978;187:337
  26. Greenwald RA, Rheingold OJ, Chiprut RO, et al.  Local gangrene: a complication of peripheral pitressin therapy for bleeding esophageal varices. Gastroenterology. 1978;74:744

PII: 0016-5085(79)90020-9

Gastroenterology
Volume 77, Issue 3 , Pages 540-546 , September 1979

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