Gastroenterology
Volume 101, Issue 1 , Pages 66-69, July 1991

Gastric acid secretion and parietal cell mass: Effect of sex hormones

Department of Human Physiology, Faculty of Medical Sciences, University of Jos, Nigeria

Abstract 

The role of sex hormones on parietal cell function and number was studied in the rat. Ovariectomy significantly increased parietal cell mass (from 18.26 +/- 0.16 x 10(6) to 24.14 +/- 0.89 x 10(6)] as well as basal acid secretion (from 3.49 +/- 0.06 to 3.63 +/- 0.05 mu Eq/10 min). Castration decreased the number of parietal cells in the gastric mucosa of male rats from 25.57 +/- 0.18 x 10(6) to 18.65 +/- 0.12 x 10(6) and basal acid secretion (from 3.99 +/- 0.03 to 3.50 +/- 0.06 mu Eq/10 min). The results suggest that male and female sex hormones regulate basal acid secretion via their effects on the parietal cell. (Gastroenterology 1991 Jul;101(1):66-9)

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PII: 0016-5085(91)90460-3

Gastroenterology
Volume 101, Issue 1 , Pages 66-69, July 1991

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