Gastroenterology
Volume 92, Issue 6 , Pages 1894-1898 , June 1987

5-Aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis, and proctitis

  • Lloyd R. Sutherland

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to: Dr. L. R. Sutherland, 3330 Hospital Drive NW, Room 1414, Calgary, Alberta, Canada T2N 4N1.
    • Department of Gastroenterology at the University of Calgary, Calgary, Canada
    • Department of Gastroenterology at the University of Montreal, Montreal, Canada
    • Department of Gastroenterology at the Scripps Medical Clinic, La Jolla, California, USA
    • Department of Gastroenterology at the Oklahoma City Clinic, Oklahoma City, Oklahoma, USA
    • Department of Gastroenterology at the Kansas University, Lawrence, Kansas, USA
    • Department of Gastroenterology at the University of Toronto, Toronto, Canada
    • Department of Gastroenterology at the St. Paul Gastroenterology, St. Paul, Minnesota, USA
    • Department of Gastroenterology at the Atlantic Gastroenterology, New Jersey, USA
    • Department of Gastroenterology at the Clinical Research Department, Reid-Rowell, Inc., Baudette, Minnesota, USA
    • ,
  • Francois Martin

      Affiliations

    • Department of Gastroenterology at the University of Calgary, Calgary, Canada
    • Department of Gastroenterology at the University of Montreal, Montreal, Canada
    • Department of Gastroenterology at the Scripps Medical Clinic, La Jolla, California, USA
    • Department of Gastroenterology at the Oklahoma City Clinic, Oklahoma City, Oklahoma, USA
    • Department of Gastroenterology at the Kansas University, Lawrence, Kansas, USA
    • Department of Gastroenterology at the University of Toronto, Toronto, Canada
    • Department of Gastroenterology at the St. Paul Gastroenterology, St. Paul, Minnesota, USA
    • Department of Gastroenterology at the Atlantic Gastroenterology, New Jersey, USA
    • Department of Gastroenterology at the Clinical Research Department, Reid-Rowell, Inc., Baudette, Minnesota, USA
    • ,
  • Scott Greer

      Affiliations

    • Department of Gastroenterology at the University of Calgary, Calgary, Canada
    • Department of Gastroenterology at the University of Montreal, Montreal, Canada
    • Department of Gastroenterology at the Scripps Medical Clinic, La Jolla, California, USA
    • Department of Gastroenterology at the Oklahoma City Clinic, Oklahoma City, Oklahoma, USA
    • Department of Gastroenterology at the Kansas University, Lawrence, Kansas, USA
    • Department of Gastroenterology at the University of Toronto, Toronto, Canada
    • Department of Gastroenterology at the St. Paul Gastroenterology, St. Paul, Minnesota, USA
    • Department of Gastroenterology at the Atlantic Gastroenterology, New Jersey, USA
    • Department of Gastroenterology at the Clinical Research Department, Reid-Rowell, Inc., Baudette, Minnesota, USA
    • ,
  • Malcolm Robinson

      Affiliations

    • Department of Gastroenterology at the University of Calgary, Calgary, Canada
    • Department of Gastroenterology at the University of Montreal, Montreal, Canada
    • Department of Gastroenterology at the Scripps Medical Clinic, La Jolla, California, USA
    • Department of Gastroenterology at the Oklahoma City Clinic, Oklahoma City, Oklahoma, USA
    • Department of Gastroenterology at the Kansas University, Lawrence, Kansas, USA
    • Department of Gastroenterology at the University of Toronto, Toronto, Canada
    • Department of Gastroenterology at the St. Paul Gastroenterology, St. Paul, Minnesota, USA
    • Department of Gastroenterology at the Atlantic Gastroenterology, New Jersey, USA
    • Department of Gastroenterology at the Clinical Research Department, Reid-Rowell, Inc., Baudette, Minnesota, USA
    • ,
  • Norton Greenberger

      Affiliations

    • Department of Gastroenterology at the University of Calgary, Calgary, Canada
    • Department of Gastroenterology at the University of Montreal, Montreal, Canada
    • Department of Gastroenterology at the Scripps Medical Clinic, La Jolla, California, USA
    • Department of Gastroenterology at the Oklahoma City Clinic, Oklahoma City, Oklahoma, USA
    • Department of Gastroenterology at the Kansas University, Lawrence, Kansas, USA
    • Department of Gastroenterology at the University of Toronto, Toronto, Canada
    • Department of Gastroenterology at the St. Paul Gastroenterology, St. Paul, Minnesota, USA
    • Department of Gastroenterology at the Atlantic Gastroenterology, New Jersey, USA
    • Department of Gastroenterology at the Clinical Research Department, Reid-Rowell, Inc., Baudette, Minnesota, USA
    • ,
  • Fred Saibil

      Affiliations

    • Department of Gastroenterology at the University of Calgary, Calgary, Canada
    • Department of Gastroenterology at the University of Montreal, Montreal, Canada
    • Department of Gastroenterology at the Scripps Medical Clinic, La Jolla, California, USA
    • Department of Gastroenterology at the Oklahoma City Clinic, Oklahoma City, Oklahoma, USA
    • Department of Gastroenterology at the Kansas University, Lawrence, Kansas, USA
    • Department of Gastroenterology at the University of Toronto, Toronto, Canada
    • Department of Gastroenterology at the St. Paul Gastroenterology, St. Paul, Minnesota, USA
    • Department of Gastroenterology at the Atlantic Gastroenterology, New Jersey, USA
    • Department of Gastroenterology at the Clinical Research Department, Reid-Rowell, Inc., Baudette, Minnesota, USA
    • ,
  • Thomas Martin

      Affiliations

    • Department of Gastroenterology at the University of Calgary, Calgary, Canada
    • Department of Gastroenterology at the University of Montreal, Montreal, Canada
    • Department of Gastroenterology at the Scripps Medical Clinic, La Jolla, California, USA
    • Department of Gastroenterology at the Oklahoma City Clinic, Oklahoma City, Oklahoma, USA
    • Department of Gastroenterology at the Kansas University, Lawrence, Kansas, USA
    • Department of Gastroenterology at the University of Toronto, Toronto, Canada
    • Department of Gastroenterology at the St. Paul Gastroenterology, St. Paul, Minnesota, USA
    • Department of Gastroenterology at the Atlantic Gastroenterology, New Jersey, USA
    • Department of Gastroenterology at the Clinical Research Department, Reid-Rowell, Inc., Baudette, Minnesota, USA
    • ,
  • Joseph Sparr

      Affiliations

    • Department of Gastroenterology at the University of Calgary, Calgary, Canada
    • Department of Gastroenterology at the University of Montreal, Montreal, Canada
    • Department of Gastroenterology at the Scripps Medical Clinic, La Jolla, California, USA
    • Department of Gastroenterology at the Oklahoma City Clinic, Oklahoma City, Oklahoma, USA
    • Department of Gastroenterology at the Kansas University, Lawrence, Kansas, USA
    • Department of Gastroenterology at the University of Toronto, Toronto, Canada
    • Department of Gastroenterology at the St. Paul Gastroenterology, St. Paul, Minnesota, USA
    • Department of Gastroenterology at the Atlantic Gastroenterology, New Jersey, USA
    • Department of Gastroenterology at the Clinical Research Department, Reid-Rowell, Inc., Baudette, Minnesota, USA
    • ,
  • Ed Prokipchuk

      Affiliations

    • Department of Gastroenterology at the University of Calgary, Calgary, Canada
    • Department of Gastroenterology at the University of Montreal, Montreal, Canada
    • Department of Gastroenterology at the Scripps Medical Clinic, La Jolla, California, USA
    • Department of Gastroenterology at the Oklahoma City Clinic, Oklahoma City, Oklahoma, USA
    • Department of Gastroenterology at the Kansas University, Lawrence, Kansas, USA
    • Department of Gastroenterology at the University of Toronto, Toronto, Canada
    • Department of Gastroenterology at the St. Paul Gastroenterology, St. Paul, Minnesota, USA
    • Department of Gastroenterology at the Atlantic Gastroenterology, New Jersey, USA
    • Department of Gastroenterology at the Clinical Research Department, Reid-Rowell, Inc., Baudette, Minnesota, USA
    • ,
  • Lowell Borgen

      Affiliations

    • Department of Gastroenterology at the University of Calgary, Calgary, Canada
    • Department of Gastroenterology at the University of Montreal, Montreal, Canada
    • Department of Gastroenterology at the Scripps Medical Clinic, La Jolla, California, USA
    • Department of Gastroenterology at the Oklahoma City Clinic, Oklahoma City, Oklahoma, USA
    • Department of Gastroenterology at the Kansas University, Lawrence, Kansas, USA
    • Department of Gastroenterology at the University of Toronto, Toronto, Canada
    • Department of Gastroenterology at the St. Paul Gastroenterology, St. Paul, Minnesota, USA
    • Department of Gastroenterology at the Atlantic Gastroenterology, New Jersey, USA
    • Department of Gastroenterology at the Clinical Research Department, Reid-Rowell, Inc., Baudette, Minnesota, USA

Received 27 March 1986 ,Accepted 1 December 1986.

References 

  1. Baron JH, Connell AM, Lennard-Jones JE, Jones FA. Sulphasalazine and salicylazosulphadimidine in ulcerative colitis. Lancet. 1962;i:1094–1096
  2. Dissanayake AS, Truelove SC. A controlled therapeutic trial of long-term maintenance treatment of ulcerative colitis with sulphasalazine. Gut. 1973;14:923–926
  3. Svartz N. Salazyopyrin, a new sulfanilamide preparation. Acta Med Scand. 1942;110:577–598 (Fasc. 6)
  4. Azad Khan KA, Piris J, Truelove SC. An experiment to determine the active therapeutic moiety of sulphasalazine. Lancet. 1977;892–895 Oct
  5. Dew MJ, Ryder RKJ, Evans BK, Rhodes J. Colonic release of 5-aminosalicylic acid from an oral preparation in active ulcerative colitis. Br J Clin Pharmacol. 1983;16:185–187
  6. Dew MJ, Hughes P, Harries AD, Williams G, Evans BK, Rhodes J. Maintenance or remission in ulcerative colitis with oral preparation of 5 amino salicylic acid. Br Med J. 1982;285:105
  7. Janssens J, Geboes K, Delanote C, et al.  5-aminosalicylic acid (5-ASA) enemas are effective in patients with resistant ulcerative rectosigmoiditis (abstr). Gastroenterology. 1983;84:1198
  8. Hanauer SB, Schultz PA, Kirsner JB. Treatment of refractory proctitis with 5-ASA enemas (abstr). Gastroenterology. 1985;88:1412
  9. Barber GB, Lee DE, Antonioli DA, et al.  Refractory distal ulcerative colitis responsive to 5-aminosalicylate enemas. Am J Gastroenterol. 1985;80:612–614
  10. Hetzel DJ, Bocher F, Imhoff DM, et al.  Azodisalicylate (ADS) in the treatment of ulcerative colitis (UC). A controlled trial and assessment of drug disposition (abstr). Gastroenterology. 1985;88:1418
  11. Ginsberg AL, Steinberg WM, Nochomovitz LE. Evaluation of 4-aminosalicylate enemas in patients with left sided ulcerative colitis (abstr). Gastroenterology. 1984;86:1089
  12. Campieri N, Lanfranchi GA, Bazzochi G, et al.  Treatment of ulcerative colitis with high-dose 5-aminosalicylic acid enemas. Lancet. 1981;ii:270–271
  13. Dew MJ, Harries AD, Evans BK, Rhodes J. Treatment of ulcerative colitis with oral 5 amino salicylic acid in patients unable to take sulphasalazine. Lancet. 1983;ii:801
  14. Campieri N, Lanfranchi G, Brignola C, Bazzocchi G, Minguzzi M, Calari M. 5-Aminosalicylic acid as rectal enema in ulcerative colitis patients unable to take sulphasalazine. Lancet. 1984;i:403
  15. Powell-Tuck J, Day DW, Buckell NA, et al.  Correlations between sigmoidoscopic appearances and other measures of disease activity in ulcerative colitis. Dig Dis Sci. 1982;27:533–537

☆ This work was sponsored by Reid-Rowell Inc., Baudette, Minnesota, and Interfalk Canada, Beloil, PQ, Canada.

PII: 0016-5085(87)90621-4

Gastroenterology
Volume 92, Issue 6 , Pages 1894-1898 , June 1987

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