Gastroenterology
Volume 87, Issue 1 , Pages 234-237 , July 1984

The intestinal immune system: A time for the reaper

  • Albert L. Jones, M.D. (Professor of Medicine and Anatomy, Director)

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to: Albert L. Jones, M.D., Chief, Cell Biology and Aging Section, Veterans Administration Medical Center, 151E, 4150 Clement Street, San Francisco, California 94121.
    • University of California, San Francisco, USA
    • Intestinal Immunology Research Center Veterans Administration Medical Center and the University of California San Francisco, California, USA

References 

  1. Manning RJ, Walker PG, Carter L, Barrington PJ, Jackson GDF. Studies on the origins of biliary immunoglobulins in rats. Gastroenterology. 1984;87:173–179
  2. Heremans JF, Heremans M-Th, Schultze HE. Isolation and description of a few properties of the β2A globulin of human serum. Clin Chim Acta. 1959;4:96–102
  3. Tomasi TB, Larson L, Challacombe S, McNabb P. Mucosal immunity: the origin and migration patterns of cells in the secretory system. J Allergy Clin Immunol. 1980;65:12–19
  4. Brown WR, Newcomb RW, Ishizaka K. Proteolytic degradation of exocrine and serum immunoglobulins. J Clin Invest. 1970;49:1374–1380
  5. Owen RL, Jones AL. Epithelial cell specialization within human Payer's patches: an ultrastructural study of intestinal lymphoid follicles. Gastroenterology. 1974;66:189–203
  6. Kawanishi H, Saltzman L, Strober W. Mechanisms regulating IgA class-specific immunoglobulin production in murine gut-associated lymphoid tissues. J Exp Med. 1983;158:649–669
  7. Butcher EC, Rouse RV, Coffman RL, Nottenberg CN, Hardy R, Weissman IL. Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation. J Immunol. 1984;129:2698–2707
  8. Jackson GDF, Lemaitre-Coelho I, Vaerman J-P, Bazin H, Beckers A. Rapid disappearance from serum of intravenously injected rat myeloma IgA and its secretion into bile. Eur J Immunol. 1978;8:123–126
  9. Brown TA, Russel MW, Mestecky J. Elimination of intestinally absorbed antigen into the bile by IgA. J Immunol. 1984;132:780–782
  10. Fisher MM, Nagy B, Bazin H, Underdown BJ. Biliary transport of IgA: role of secretory component. In: Proc Natl Acad Sci USA. 76:1979;p. 2008–2012
  11. Renston RH, Jones AL, Christiansen WD, Hradek GT, Underdown BJ. Evidence for a vesicular transport mechanism in hepatocytes for biliary secretion of immunoglobulin A. Science. 1980;208:1276–1278
  12. Goldman IS, Jones AL, Hradek GT, Huling S. Hepatocyte handling of immunoglobulin A in the rat: the role of microtubules. Gastroenterology. 1983;85:130–140
  13. Mullock BM, Hinton RH, Dobrotta M. Distribution of secretory component in hepatocytes and its mode of transfer into bile. Biochem J. 1980;190:819–826
  14. Mostov KE, Kraehenbuhl JP, Blobel G. Receptor-mediated transcellular transport of immunoglobulin; synthesis of secretory component as multiple and larger transmembrane forms. In: Proc Natl Acad Sci USA. 77:1980;p. 7257–7261
  15. Kloppel TM, Reicher J, Brown WR. Evidence that secretory component (SC) in rat bile is a proteolytic product of hepatocyte membrane SC (abstr). Gastroenterology. 1983;84:1379
  16. Sztyl ES, Howell KE, Palade GE. Intracellular and transcellular transport of secretory component and albumin in rat hepatocytes. J Cell Biol. 1983;97:1582–1591
  17. Kutteh WH, Prince SJ, Phillips JD, et al.  Properties of immunoglobulin A in serum of individuals with liver diseases and in hepatic bile. Gastroenterology. 1982;82:184–193

PII: 0016-5085(84)90153-7

Gastroenterology
Volume 87, Issue 1 , Pages 234-237 , July 1984

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