Gastroenterology
Volume 87, Issue 1 , Pages 228-229 , July 1984

Peptides, sulfhydryls, and glucocorticoids in gastric mucosal defense: Coincidence or connection?

  • Sandor Szabo, M.D., Ph.D.

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to: Dr. Sandor Szabo, Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, Massachusetts 02115.

References 

  1. Robert A. Cytoprotection by prostaglandins. Gastroenterology. 1979;77:761–767
  2. Konturek SJ, Brzozowski T, Piastucki I, et al.  Role of mucosal prostaglandins and DNA synthesis in gastric cytoprotection by luminal epidermal growth factor. Gut. 1981;22:927–932
  3. Szabo S, Trier JS, Frankel PW. Sulfhydryl compounds may mediate gastric cytoprotection. Science. 1981;214:200–202
  4. Skov Olsen P, Poulsen SS, Kirkegaard P, Nexø E. Role of submandibular saliva and epidermal growth factor in gastric cytoprotection. Gastroenterology. 1984;87:103–108
  5. Szabo S, Horner HC, Gallagher GT. Drug-induced duodenal ulcer: structure-activity correlations and pathogenesis. In:  Pfeiffer CJ editors. Drugs and peptic ulcer. Vol 2:Boca Raton: CRC Press; 1982;p. 55–74
  6. Kirkegaard P, Skov Olsen P, Poulsen SS, Nexø E. Epidermal growth factor inhibits cysteamine-induced duodenal ulcer. Gastroenterology. 1983;85:1277–1283
  7. Lacy ER, Ito S. Microscopic analysis of ethanol damage to gastric mucosa after treatment with a prostaglandin. Gastroenterology. 1982;83:619–625
  8. Barka T. Biologically active polypeptides in submandibular glands. J Histochem Cytochem. 1980;28:836–859
  9. Carpenter G, Cohen S. Epidermal growth factor. Annu Rev Biochem. 1979;48:193–216
  10. Szabo S, Trier JS. Pathogenesis of acute gastric mucosal injury: sulfhydryls as a protector, adrenal cortex as a modulator, and vascular endothelium as a target. In:  Allen A,  Flemstrom G,  Garner A,  Silen W,  Turnberg LA editor. Mechanisms of mucosal protection in the upper gastrointestinal tract. New York: Raven; 1984;p. 287–293
  11. Szabo S, Usadel KH. Cytoprotection—organoprotection by somatostatin: gastric and hepatic lesions. Experientia. 1982;38:254–255
  12. Le-Quoc K, Le-Quoc D. Control of the mitochondrial inner membrane permeability by sulfhydryl groups. Arch Biochem Biophys. 1982;216:639–651
  13. McAbee DD, Grinnell F. Thiol-sensitive sites in cell adhesion. Decreased entry of SH-binding reagents into attached BHK cells. Biochem J. 1982;208:473–478
  14. Vauquelin G, Maguire ME. Inactivation of beta-adrenergic receptors by N-ethylmaleimide in S49 lymphoma cells. Agonist induction of functional receptor heterogeneity. Mol Pharmacol. 1980;18:362–369
  15. Szabo S, Reynolds ES, Unger SH. Structure-activity relations between alkyl nucleophilic chemicals causing duodenal ulcer and adrenocortical necrosis. J Pharmacol Exp Ther. 1982;223:68–76
  16. Sadiq HF, Devaskar UP. Glucocorticoids increase pulmonary epidermal growth factor receptors in female and male fetal rabbit. Biochem Biophys Res Commun. 1984;119:408–414
  17. Szabo S, Gallagher GT, Homer HC, et al.  Role of the adrenal cortex in gastric mucosal protection by prostaglandins, sulfhydryls, and cimetidine in the rat. Gastroenterology. 1983;85:1384–1390
  18. Mizui T, Doteuchi M. Effect of polyamines on acidified ethanol-induced gastric lesions in rats. Jpn J Pharmacol. 1983;33:939–945

PII: 0016-5085(84)90151-3

Gastroenterology
Volume 87, Issue 1 , Pages 228-229 , July 1984

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