Gastroenterology
Volume 87, Issue 1 , Pages 28-36, July 1984

Regional gastric mucosal blood flow measurements by hydrogen gas clearance in the anesthetized rat and rabbit☆

  • Felix W. Leung

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to: Felix W. Leung, M.D., Veterans Administration Wadsworth Medical Center, 691/111C, Los Angeles, California 90073.
    • Center for Ulcer Research and Education (CURE), Research, Medical, and Surgical Services, Veterans Administration Wadsworth Medical Center Los Angeles, California, USA
    • UCLA School of Medicine, Los Angeles, California, USA
    • ,
  • Paul H. Guth

      Affiliations

    • Center for Ulcer Research and Education (CURE), Research, Medical, and Surgical Services, Veterans Administration Wadsworth Medical Center Los Angeles, California, USA
    • UCLA School of Medicine, Los Angeles, California, USA
    • ,
  • Oscar U. Scremin

      Affiliations

    • Center for Ulcer Research and Education (CURE), Research, Medical, and Surgical Services, Veterans Administration Wadsworth Medical Center Los Angeles, California, USA
    • UCLA School of Medicine, Los Angeles, California, USA
    • ,
  • Elizabeth M. Golanska

      Affiliations

    • Center for Ulcer Research and Education (CURE), Research, Medical, and Surgical Services, Veterans Administration Wadsworth Medical Center Los Angeles, California, USA
    • UCLA School of Medicine, Los Angeles, California, USA
    • ,
  • Gordon L. Kauffman Jr.

      Affiliations

    • Center for Ulcer Research and Education (CURE), Research, Medical, and Surgical Services, Veterans Administration Wadsworth Medical Center Los Angeles, California, USA
    • UCLA School of Medicine, Los Angeles, California, USA

Received 22 August 1983; accepted 22 January 1984.

Abstract 

Hydrogen gas clearance using 3% hydrogen in air and platinum contact electrodes was employed for measuring antral and corpus mucosal Wood flow in anesthetized animals. Significantly greater antral than corpus mucosal blood flow was consistently demonstrated. Corpus but not antral mucosal blood flow showed a significant dose-related increase with intravenous pentagastrin. Vasopressin induced a significant dose-related decrease in both antral and corpus mucosal blood flow. Simultaneous measurement of basal corpus mucosal blood flow by hydrogen gas clearance and of gastric mucosal blood flow by aminopyrine clearance gave similar values, but the changes with intravenous pentagastrin or vasopressin measured by aminopyrine clearance were of a much higher order of magnitude. Hydrogen gas clearance, however, reflected changes in left gastric artery blood flow much more closely than did aminopyrine clearance. Therefore, we conclude that the hydrogen gas clearance technique as described is valid for measuring regional gastric mucosal blood flow. It is safe and has potential application in human studies.

Abbreviations:  dmPGE2, 16, 16-dimethyl prostaglandin E2

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☆ This work was supported by National Institute of Arthritis, Metabolism, and Digestive Diseases Grants AM 25891, 27465, and 17328 to the Center for Ulcer Research and Education (CURE) and by Veterans Administration Research funds.

PII: 0016-5085(84)90122-7

Gastroenterology
Volume 87, Issue 1 , Pages 28-36, July 1984

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