Gastroenterology
Volume 80, Issue 5, Part 1 , Pages 947-956 , May 1981

Adaptation to increasing loads of total parenteral nutrition: Metabolic, endocrine, and insulin receptor responses

Received 12 September 1980 ,Accepted 4 December 1980.

References 

  1. Dudrick SJ, Ruberg RL. Principles and practice of parenteral nutrition. Gastroenterology. 1971;61:901–910
  2. Scribner BH, Cole JJ, Christopher JE, et al.  Long-term total parenteral nutrition: the concept of an artificial gut. JAMA. 1970;212:457–463
  3. Jeejeebhoy KN, Langer B, Tsallas G, et al.  Total parenteral nutrition at home: studies in patients surviving 4 months to 5 years. Gastroenterology. 1976;71:943–953
  4. Shils ME. A program for total parenteral nutrition at home. Am J Clin Nutr. 1975;28:1429–1435
  5. Langer B, McHattie JD, Zohrab WJ, et al.  Prolonged survival after complete small bowel resection using intravenous alimentation at home. J Surg Res. 1973;15:226–233
  6. Byrne WJ, Ament ME, Burke M, et al.  Home parenteral nutrition. Surg Gynecol Obstet. 1979;149:593–599
  7. Felig P. Parenteral nutrition: substance and secretagogue. N Engl J Med. 1972;287:982
  8. Strobel CT, Byrne WJ, Fonkalsrud EW, Ament ME. Home parenteral nutrition: results in 34 pediatric patients. Ann Surg. 1978;188:394–403
  9. Hiller A, Plazin J, Van Slyke DD. A study of conditions for Kjeldahl determination of nitrogen in proteins. J Biol Chem. 1948;176:1401–1420
  10. Calloway DH, Odell ACF, Margen S. Sweat and miscellaneous nitrogen losses in human balance studies. J Nutrition. 1971;101:775–786
  11. Ensinck JW, Shepard C, Dudl J, et al.  Use of benzamidine as a proteolytic inhibitor in the radioimmunoassay of glucagon in plasma. J Clin Endocrinol Metabol. 1972;35:463–466
  12. Faloona GR, Unger RH. Glucagon. In: 1st ed..  Jaffe BM,  Behrman HR editor. Methods of hormone radioimmunoassay. 18:New York: Academic Press; 1974;p. 317–330
  13. Lundquist I, Fanska R, Grodsky G. Interaction of calcium and glucose on glucagon secretion. Endocrinology. 1976;99:1304–1312
  14. Schalch DS, Parker ML. A sensitive double antibody immunoassay for human growth hormone in plasma. Nature (Lond). 1964;203:1141–1142
  15. Boyum A. Separation of leukocytes from blood and bone marrow. Scand J Clin Lab Invest. 1968;21(Suppl 97):77–89
  16. Neufeld ND, Kaplan SA, Lippe BM, et al.  Increased monocyte receptor binding of 125-I insulin in infants of gestational diabetic mothers. J Clin Endocrinol Metab. 1978;47:590–595
  17. Scatchard G. The attractions of proteins for small molecules and ions. Ann NY Acad Sci. 1949;51:660–672
  18. Sanderson I, Deitel M. Insulin response in patients receiving concentrated infusions of glucose and casein hydrolysate for complete parenteral nutrition. Ann Surg. 1974;179:387–394
  19. Felig P, Wahren J. Fuel homeostasis in exercise. N Engl J Med. 1975;293:1078–1084
  20. Genuth SM. Plasma insulin and glucose profiles in normal, obese, and diabetic persons. Ann Intern Med. 1973;79:812–822
  21. Muller WA, Faloona GR, Unger RH. The effect of alanine on glucagon secretion. J Clin Invest. 1971;50:2215–2218
  22. Genuth SM. Insulin response to intravenous alimentation. N Engl J Med. 1973;289:107
  23. DeFronzo RA, Andres R, Bledsoe TA, et al.  A test of the hypothesis that the rate of fall in glucose concentration triggers counterregulatory hormonal responses in man. Diabetes. 1977;26:445–452
  24. Lilavivathana U, Brodows RG, Woolf RD, et al.  Counterregulatory hormonal responses to rapid glucose lowering in diabetic man. Diabetes. 1979;28:873–877
  25. DeFronzo RA, Hendler R, Christensen N. Stimulation of counterregulatory hormonal responses in diabetic man by a fall in glucose concentration. Diabetes. 1980;29:125–131
  26. Rizza RA, Cryer PE, Gerich JE. Role of glucagon, catecholamines, and growth hormone in human glucose counterregulation: effects of somatostatin and combined α- and β-adrenergic blockade on plasma glucose recovery and glucose flux rates after insulin-induced hypoglycemia. J Clin Invest. 1979;64:62–71
  27. Raskin P, Aydin I, Yamamoto T, et al.  Abnormal alpha cell function in human diabetes: response to oral protein. Am J Med. 1978;64:988–997
  28. Gerich JE, Tsalikian E, Lorenzi M, et al.  Normalization of fasting hyperglucagonemia and excessive glucagon responses to intravenous arginine in human diabetes mellitus by prolonged infusion of insulin. J Clin Endocrinol Metabol. 1975;41:1178–1180
  29. Hansen AP. Abnormal serum growth hormone response to exercise in juvenile diabetics. J Clin Invest. 1970;49:1467–1478
  30. Merimee TJ, Fitzgerald CR, Gold LA, et al.  Characteristics of growth hormone secretion in clinically stable diabetes. Diabetes. 1979;28:308–312
  31. Hayford JT, Danney MM, Hendrix JA, et al.  Integrated concentration of growth hormone in juvenile-onset diabetes. Diabetes. 1980;29:391–398
  32. Roth J. Peptide hormone binding to receptors: a review of direct studies in vitro. Metabolism. 1973;22:1059–1073
  33. Olefsky JM. The insulin receptor: Its role in insulin resistance of obesity and diabetes. Diabetes. 1976;25:1154–1162
  34. Wachslicht-Rodbard H, Gross HA, Rodbard D, et al.  Increased insulin receptor binding to erythrocytes in anorexia nervosa: restoration to normal with refeeding. N Engl J Med. 1979;300:882–887
  35. Kolterman OG, Insel J, Saekow M, et al.  Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects. J Clin Invest. 1980;65:1272–1284
  36. Archer JA, Gorden P, Roth J. Defect in insulin binding to receptors in obese man: amelioration with caloric restriction. J Clin Invest. 1975;55:166–174
  37. Lippe BM, Kaplan ND, Neufeld A, et al.  Insulin receptors in cystic fibrosis: increased receptor number and altered affinity. Pediatrics. 1980;65:1018–1022

 This work was presented in part at the Western Society for Pediatric Research, 1980; the American Diabetes Association Meeting, 1980; and the International Society of Total Parenteral Nutrition, Rio de Janeiro, 1978.This study was supported in part by USPHS RR-865, grants to B. Lippe, MD, from the American Diabetes Association, Inc., and the Cystic Fibrosis Foundation, to S. R. Levin, MD, from the Veterans Administration, NIH AM 21031-03, the American Diabetes Association, and the Kroc Foundation.

PII: 0016-5085(81)90064-0

Gastroenterology
Volume 80, Issue 5, Part 1 , Pages 947-956 , May 1981