Gastroenterology
Volume 77, Issue 3 , Pages 547-555, September 1979

Inhibition of the growth of Morris Hepatoma #44 in rats after induction of hypothyroidism: Evidence that Morris Hepatomas are thyroid dependent☆

This work is dedicated to the memory of Mr. Moe Yalovsky.

  • Seymour Mishkin

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to: Dr. Seymour Mishkin, Division of Gastrocnterology, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1.
    • Department of Medicine, Royal Victoria Hospital and McGill University Clinic, Montreal, Quebec, Canada
    • Department of Biochemistry, Howard University School of Medicine Washington, D.C., USA
    • ,
  • Harold P. Morris

      Affiliations

    • Department of Medicine, Royal Victoria Hospital and McGill University Clinic, Montreal, Quebec, Canada
    • Department of Biochemistry, Howard University School of Medicine Washington, D.C., USA
    • ,
  • Morty A. Yalovsky

      Affiliations

    • Department of Medicine, Royal Victoria Hospital and McGill University Clinic, Montreal, Quebec, Canada
    • Department of Biochemistry, Howard University School of Medicine Washington, D.C., USA
    • ,
  • P.V.Narasimha Murthy

      Affiliations

    • Department of Medicine, Royal Victoria Hospital and McGill University Clinic, Montreal, Quebec, Canada
    • Department of Biochemistry, Howard University School of Medicine Washington, D.C., USA

Received 1 February 1979; accepted 14 May 1979.

Abstract 

The growth rate of Morris Hepatoma #44 (generation time, 6 mo) was inhibited after the induction of hypothyroidism by Propylthiouracil (PTU) (0.1% in Purina Chow), I131 (1 mCi/100 g body wt i.p.), or surgical thyroidectomy. After 11 wk of treatment, hepatoma weight was 66%, 87%, and 75% (after correction for total body wt) relative to controls in PTU-fed, I131 injected, and thyroidectomized rats, respectively. In each case, exogenous thyroxine (T4) (8 μg/kg body wt i.p.) reversed these inhibitory effects, while T4 administered to euthyroid rats stimulated hepatoma growth. The degree of growth-inhibition achieved with PTU was not observed in pair-fed rats. In addition, after correction for differences in body weight, the sex of the tumor-bearing rats did not influence the response to PTU. Pretreatment with PTU for 2 wk before implantation did not give any added advantage over the effects of PTU administered approximately 10 days after implantation. Serum levels of triiodothyronine (T3) and T4, as well as the concentration of various biochemic parameters, were determined at the time of death. These results suggest that the growth rate of Morris Hepatoma #44 is thyroid hormone dependent.

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☆ This study was supported by grants from the Canadian Medical Research Council (MA 5474), the National Cancer Institute of Canada, and U.S.P.H.S. Grant (Ca10729).

PII: 0016-5085(79)90021-0

Gastroenterology
Volume 77, Issue 3 , Pages 547-555, September 1979

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