Gastroenterology
Volume 77, Issue 3 , Pages 537-539 , September 1979

Histocompatibility antigens in patients with hepatocellular carcinoma and their relationship to chronic hepatitis B virus infection in these patients

  • Michael C. Kew

      Affiliations

    • Corresponding Author InformationAddress requests for reprints to: Prof. M. C. Kew, Department of Medicine, University of the Witwatersrand Medical School, Hospital Hill, Johannesburg, South Africa 2001.
    • The Department of Medicine, Johannesburg Hospital, Johannesburg, South Africa
    • The Department of Medicine, University of the Witwatersrand, the Tissue Bank, Johannesburg, South Africa
    • Department of Immunology, School of Pathology of the South African Institute for Medical Research and University of the Witwatersrand, Johannesburg, South Africa
    • Department of Immunology, The South African Primary Liver Cancer Research Unit, Johannesburg, South Africa
    • ,
  • Anthony J. Gear

      Affiliations

    • The Department of Medicine, Johannesburg Hospital, Johannesburg, South Africa
    • The Department of Medicine, University of the Witwatersrand, the Tissue Bank, Johannesburg, South Africa
    • Department of Immunology, School of Pathology of the South African Institute for Medical Research and University of the Witwatersrand, Johannesburg, South Africa
    • Department of Immunology, The South African Primary Liver Cancer Research Unit, Johannesburg, South Africa
    • A. J. Gear is a South African Chamber of Mines Research Fellow.
    • ,
  • Ingrid Baumgarten

      Affiliations

    • The Department of Medicine, Johannesburg Hospital, Johannesburg, South Africa
    • The Department of Medicine, University of the Witwatersrand, the Tissue Bank, Johannesburg, South Africa
    • Department of Immunology, School of Pathology of the South African Institute for Medical Research and University of the Witwatersrand, Johannesburg, South Africa
    • Department of Immunology, The South African Primary Liver Cancer Research Unit, Johannesburg, South Africa
    • ,
  • Geoffrey M. Dusheiko

      Affiliations

    • The Department of Medicine, Johannesburg Hospital, Johannesburg, South Africa
    • The Department of Medicine, University of the Witwatersrand, the Tissue Bank, Johannesburg, South Africa
    • Department of Immunology, School of Pathology of the South African Institute for Medical Research and University of the Witwatersrand, Johannesburg, South Africa
    • Department of Immunology, The South African Primary Liver Cancer Research Unit, Johannesburg, South Africa
    • ,
  • Gunthild Maier

      Affiliations

    • The Department of Medicine, Johannesburg Hospital, Johannesburg, South Africa
    • The Department of Medicine, University of the Witwatersrand, the Tissue Bank, Johannesburg, South Africa
    • Department of Immunology, School of Pathology of the South African Institute for Medical Research and University of the Witwatersrand, Johannesburg, South Africa
    • Department of Immunology, The South African Primary Liver Cancer Research Unit, Johannesburg, South Africa

Received 26 March 1979 ,Accepted 1 May 1979.

References 

  1. Svejgaard A, Platz P, Ryder LP, et al.  HLA and disease associ ations—A survey. Transplant Rev. 1975;22:3
  2. Shell GD. The H-2 locus of the mouse: observations and speculations concerning its comparative genetics and its polymorphism. Folia Biol Prague. 1968;14:335
  3. Kew MC. Hepatoma and the hepatitis-B virus. In:  Vyas GN,  Cohen SN,  Schmid R editor. Viral Hepatitis. Philadelphia: The Franklin Institute Press; 1978;p. 439–450
  4. Hillis WD, Hillis A, Bias WB, et al.  Associations of hepatitis B surface antigenemia with HLA locus B specificities. N Engl J Med. 1977;296:1310
  5. Boettcher B. Some possible causes of associations between HLA antigens and disease. Immunogenetics. 1975;2:485
  6. Sherlock S, Niazi SP, Fox RA, et al.  Chronic liver disease and primary liver cell cancer with hepatitis-associated (Australia) antigen in the serum. Lancet. 1970;2:1243
  7. MacDonald RA. Primary carinoma of the liver: a clinico-pathologic study of 108 cases. Arch Intern Med. 1957;99:266
  8. Scott BB, Rajah SM, Losowsky MS. Histocompatibility antigens in chronic liver disease. Gastroenterology. 1977;72:122
  9. Prince AM, Brotman B, Jass D, et al.  Specificity of the direct solid-phase radioimmunoassay for detection of hepatitis-B antigen. Lancet. 1973;1:1346
  10. Simons MJ, Wee GB, Chan SH, et al.  Probable identification of an HLA second-locus antigen associated with a high rise of nasopharyngeal carcinoma. Lancet. 1975;1:142
  11. Hammond MG, Appadodoo B, Brain P. HLA and cancer in South African negroes. Tissue Antigens. 1977;9:1
  12. Blumberg BS, Friedlander JS, Woodside A, et al.  Hepatitis and Australia antigen:autosomal recessive inheritance of susceptibility to infection in tumours. In: Proc Natl Acad Sci. 62:1969;p. 1108
  13. Patterson MJ, Hourani MR, Mayor GH. HLA antigens and hepatitis-B virus. N Engl J Med. 1977;297:1124
  14. Penner E, Grabner G, Dittrich H, et al.  HLA antigens in HBs antigen positive chronic active hepatitis. Tissue Antigens. 1977;10:63

☆ This work was supported by grants from the South African Chamber of Mines and the National Cancer Association of South Africa.

PII: 0016-5085(79)90019-2

Gastroenterology
Volume 77, Issue 3 , Pages 537-539 , September 1979

Article Tools